1,721,301 research outputs found
New meanings for public housing through the co-production of knowledge - Policies for every day life in marginal neighbourhoods
No full textDarbepoetin alfa and history of thromboembolic events
No full textPooled analysis of individual patient-level data from all randomized, double-blind, placebo-controlled trials of darbepoetin alfa in the treatment of patients with chemotherapy-induced anemi
Palbociclib. efficacious but predictive biomarkers still needed
No full textSeveral therapeutic options are available for management of premenopausal patients with metastatic hormonereceptor- positive breast cancer, including single-agent endocrine therapy or combination regimens. Single agent treatment with an aromatase inhibitor or tamoxifen has resulted in major improvements in the adjuvant setting but has shown little clinical benefi t in metastatic disease.1,2 Endocrine therapy is the standard of care for hormone-receptor-positive luminal, HER2-negative metastatic breast cancer. However, resistance to endocrine treatment remains a major clinical problem, especially for patients with metastatic disease. Therefore management of resistance to endocrine therapy is an active area of research.
Città immaginate: il Pigneto-Prenestino e la sua fabbrica. Rigenerazione urbana e pratiche dal basso
Full text linkLa tesi si propone di contribuire alla ricerca sulle forme di intervento sulla città esistente, ponendosi alcuni obiettivi specifici correlati. In particolare, anche mediante l’analisi del caso-studio, assume importanza il riconoscimento delle possibili interazioni fra politiche e pratiche. Il lavoro si articola a partire dall’approfondimento teorico-interpretativo sulle caratteristiche dell’urbanizzazione contemporanea, sulle grandi problematiche ecologiche odierne e gli spazi di azione per individui e comunità nelle trasformazioni urbane. Passando per l’analisi critica delle politiche urbanistiche romane degli ultimi venticinque anni, la ricerca approfondisce il caso studio della riappropriazione ad uso pubblico dell’area dell’ex fabbrica Snia Viscosa nel quartiere del Pigneto-Prenestino, ritenuto significativo in ragione degli obiettivi descritti in precedenza. Le conclusioni, infine, si inseriscono all’interno del dibattito sulle possibilità di trasformazione dell’esistente e sul ruolo della conoscenza urbanistica in tal senso, lasciando dei margini di apertura per immaginare sviluppi e traiettorie future
Sequential therapy in metastatic clear cell renal carcinoma: TKI-TKI vs TKI-mTOR.
No full textWith seven targeted agents, directed against the VEGF/VEGF receptor (VEGFR) axis or the mTOR pathway, approved for the treatment of metastatic renal cell carcinoma and more active agents in advanced phase of clinical testing, questions have arisen with regard to their optimal use, either in combination or in sequence. One of the most compelling (and debated) issues is whether continued VEGF/VEGFR inhibition with agents hitting the same targets (TKI-TKI) affords better results than switching mechanisms of action by alternating VEGFR and mTOR inhibition (TKI-mTOR). In this article, the authors review the (little) available evidence coming from randomized Phase III clinical trials and try to fill in the (many) remaining gaps using evidence from small-size, single-arm Phase II studies and retrospective series, as well as reviewing preclinical evidence supporting either strategy
Re: Survival With Aromatase Inhibitors and Inactivators Versus Standard Hormonal Therapy in Advanced Breast Cancer: Meta-analysis [Mauri D et al, J Natl Cancer Inst 2006; 98: 1285 – 91]
No full textNon applicabile
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