1,721,024 research outputs found
IMPORTANZA DELLA COMBINAZIONE DEI METODI DI ETERO ED AUTOVALUTAZIONE DEL DOLORE PER UNA CORRETTA TERAPIA ANTALGICA.
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A pilot study of high-dose carboplatin and pulsed etoposide in the treatment of childhood solid tumors.
No full textCarboplatin was administered at 1,000 mg/m2/course in combination with etoposide at 300 mg/m2/course to 23 patients aged 5 months to 16 years. Five patients were affected by neuroblastoma, four by CNS tumors, three by Ewing's sarcoma, two by rhabdomyosarcoma, two by malignant teratoma, two by Wilms' tumor, two by head and neck carcinoma, one by hepatoblastoma, one by synovial sarcoma, and one by Langerhans-cell histiocytosis. Eleven patients were pretreated, seven of them with high-dose cisplatin. The overall response rate was 7/11 (64%) for pretreated and 10/12 (83%) for previously untreated patients. Myelosuppression was the main side effect, with anemia and thrombocytopenia more pronounced than leukopenia. Gastrointestinal toxicity and ototoxicity were very mild; nephrotoxicity and neurotoxicity other than hearing loss were not observed. In children with malignant tumors, the therapeutic activity of carboplatin at high doses, even in combination chemotherapy, deserves further studies
Ruolo dei polimorfismi del PAI-1 e della trombosi intratumorale nell'invasività dei tumori infantili
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Vincristine, Irinotecan, and Bevacizumab in relapsed Wilms tumor with diffuse anaplasia
No full textThe prognosis of relapsed Wilms tumor (WT) with diffuse anaplasia is dismal, therefore, novel therapeutic strategies need to be explored. We reported on 2 consecutive cases with relapsed anaplastic WT who presented a partial response after 2 courses of vincristine, irinotecan, and bevacizumab association. This regimen may have a role in the treatment of patients with anaplastic advanced WT
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