36 research outputs found
High-risk Pancreatic Anastomosis Versus Total Pancreatectomy After Pancreatoduodenectomy
No full textTo evaluate total pancreatectomy (TP) as an alternative to pancreatoduodenectomy (PD) in patients at high-risk for postoperative pancreatic fistula (POPF)
Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence
No full textAbstract An important epigenetic switch marks the onset and maintenance of senescence. This allows transcription of the genetic programs that arrest the cell cycle and alter the microenvironment. Transcription of endogenous retroviruses (ERVs) is also a consequence of this epigenetic switch. In this manuscript, we have identified a group of ERVs that are epigenetically silenced in proliferating cells but are upregulated during replicative senescence or during various forms of oncogene-induced senescence, by RAS and Akt, or after HDAC4 depletion. In a HDAC4 model of senescence, removal of the repressive histone mark H3K27me3 is the plausible mechanism that allows the transcription of intergenic ERVs during senescence. We have shown that ERVs contribute to the accumulation of dsRNAs in senescence, which can initiate the antiviral response via the IFIH1-MAVS signaling pathway and thus contribute to the maintenance of senescence. This pathway, and MAVS in particular, plays an active role in shaping the microenvironment and maintaining growth arrest, two essential features of the senescence program
Multipotent cells can be generated in vitro from several adult human organs (heart, liver and bone marrow)
No full textThe aims of our study were to verify whether it was possible to generate in vitro, from different adult human tissues, a population of cells that behaved, in culture, as multipotent stem cells and if these latter shared common properties. To this purpose, we grew and cloned finite cell lines obtained from adult human liver, heart, and bone marrow and named them human multipotent adult stem cells (hMASCs). Cloned hMASCs, obtained from the 3 different tissues, pressed the pluripotent state–specific transcription factors Oct-4, NANOG, and REX1, displayed telomerase activity, and exhibited a wide range of differentiation potential, as shown both at a morphologic and functional level. hMASCs main- tained a human diploid DNA content, and shared a common gene expression signature, compared with several somatic cell lines and irrespectively of the tissue of isolation. In particular, the pathways regu- lating stem cell self-renewal/maintenance,
such as Wnt, Hedgehog, and Notch, were transcriptionally active. Our findings demonstrate that we have optimized an in vitro protocol to generate and expand cells from multiple organs that could be induced to acquire morphologic and functional features of mature cells even embryologically not related to the tissue of origin
Validation of the ejection fraction-velocity ratio: a new simplified “function-corrected” index for assessing aortic stenosis severity
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Slovenščina in furlanščina: poskus primerjave jezikovnega načrtovanja/Sloveno e friulano: un tentativo di confronto della pianificazione linguistica
No full textIn base alle osservazioni rivolte alle linee generali di pianificazione linguistica attuate nella Regione autonoma Friuli Venezia Giulia, si compie un tentativo di confrontare, ove pos- sibile, i settori di intervento dello sloveno e del friulano, in particolare nell’ambito dell’e- ducazione. Lo spazio geografico di riferimento è, nello specifico, la provincia di Udine. Nel contributo si procede innanzi tutto alla valutazione di determinati contenuti e princi- pi espressi nei testi legislativi specifici che permetterebbero di comprendere le potenzialità di un’eventuale politica anche nell’ottica del pluralismo linguistico. In seguito si cerca di individuare gli organi principali che emanano le disposizioni in materia di pianificazione linguistica, gli strumenti e le modalità di messa in opera della stessa, mettendo in evidenza alcune importanti esperienze.
Poiché i principi espressi dagli strumenti di tutela, che richiamano la normativa statale, euro- pea e internazionale in materia, permetterebbero un livello di sviluppo elevato della condizio- ne linguistica delle comunità interessate, l’autore mette a disposizione alcuni dati che mettono in luce la discrepanza tra il livello dichiarativo o programmatico della politica linguistica e lo stato reale. In questo senso si accenna anche al ruolo svolto diffusamente dal dissenso espresso in atteggiamenti, opinioni e ideologie che ostacolano la libertà di esercitare o di ampliare, secondo le aspirazioni dei parlanti, il diritto di usare nella vita sociale le lingue altre.
According to the observation made of the general lines of language planning, implemented in the Autonomous Region of Friuli Venezia Giulia, the author makes an attempt to compare, where possible, the areas of Slovenian and Friulan intervention, particularly in the field of education. The geographical space of reference is, specifically, the province of Udine.
He proceeds firstly to the evaluation of certain contents and principles, expressed in specific legislation, that would allow to understand the potential of any policy, also in the perspective of the interaction and linguistic pluralism. He tries then to identify the major organs that enact the regulations on language planning, as well as the tools and the procedures for its implementation, also by emphasizing some important experiences. Since the principles expressed by the means of protection, which recall the state, European and international legislation, would allow a high level of development of the linguistic condition of the concerned communities, the author provides some data which highlight the discrepancy between the declarative or programmatic level of language policy and the real state. In this sense, he also hints at the role played by the widespread disagreement expressed in attitudes, opinions and ideologies that hinder the freedom to exercise or to expand, according to the aspirations of the speakers, the right to use in social life the different languages
Management and 5-year outcome of patients with coronary artery disease in different periods of stent technology
No full textPulmonary artery hypertension in adult patients with symptomatic valvular aortic stenosis
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