1,794,984 research outputs found
Synthesis of Alkyl Citrates (−)-CJ-13,981, (−)-CJ-13,982, and (−)-L-731,120 via a Cyclobutene Diester
No full textAn
efficient and step-economic new approach to alkyl citrate natural
products from a cyclobutene diester is presented. The key sequence
involves a formal [2 + 2]-cycloaddition of a silylketene acetal with
dimethylacetylene dicarboxylate to provide the cyclobutene diester 14 with 4.5:1 stereoselectivity. Exposure of diester 14 in acidic methanol effected a hydrolysis, intramolecular
oxy-Michael reaction, and cyclobutanone methanolysis cascade to give
the triester 15. Iodination and elimination then afforded
a key alkyl citrate alkene intermediate, which was converted into
the natural products (−)-CJ-13,982 (1), (−)-CJ-13,981
(2), and (−)-L-731,120 (3) via a
cross-metathesis and subsequent reduction
The vanishing author in computer-generated works: a critical analysis of recent Australian case law
No full textAbstract
The use of software is ubiquitous in the creation of many copyright works, yet the requirement in copyright law that every work have a human author who engages in independent intellectual effort means that its use may prevent copyright subsistence. Several recent Australian cases have refocused attention on authorship as an essential criterion of copyright subsistence, and these cases suggest that much computer-produced output may be authorless and thus lack copyright protection. This article, the first in a two-part series, analyses how each case deals with the question of authorship of computer-produced works and why the use of software diminishes copyright protection for a significant number of computer-generated works. The article critiques the application of conventional notions of human authorship developed in the pre-computer age to modern productions and suggests alternative approaches to authorship that satisfy both the major objectives of copyright policy and the need to adapt to the computer age. The article argues that, without a broader judicial approach to authorship of computer-generated works, Parliament must remedy the lacuna in protection for these ‘authorless’ works. Possible solutions for reform are suggested. In a forthcoming article, the author comprehensively examines those reform proposals
CJ Koh Webinar 2021
No full text"Led by Eminent Professors in Education who were invited to Singapore under the CJ Koh Professorship in Education Programme, NIE held 2 webinars in August and November 2021, respectively. The 1st webinar focused on Teacher Education while the 2nd webinar focused on Learners."--Website.Leading in uncertainty / Pam Grossman – The pandemic and beyond / Susan Fuhrman -- Black swan, golden goose or blessing in disguise?: Rethinking education after the pandemic / Andy Hargreaves -- Five paths of student engagement: Positive ways forward beyond the pandamic [pandemic] / Dennis Shirley – Seizing the innovation dividend of the COVID-19 pandemic / Fernando Reimers -- Can we prepare children to predicatable of [predict] unpredictable events in the future? The Finnish perspective / Hannele Niemi
Synthesis of the phthalide-containing anti-Helicobacter pylori agents CJ-13,015, CJ-13,102, CJ-13,103, CJ-13,104 and CJ-13,108
No full textFlexible racemic syntheses of the phthalide-containing antibiotics CJ-13,015, CJ-13,102, CJ-13,103, CJ-13,104 and CJ-13,108 that inhibit Helicobacter pylori have been carried out in a convergent fashion by Wittig coupling of a phthalide-containing aldehyde fragment with an appropriate phosphorous ylide
CJ Koh Professorial Lecture Series; 3
No full textThis third report in the series captures the rich and insightful discussions arising from Professor Ruth Hayhoe’s visit to NIE in her appointment as the 7th CJ Koh Professor from 30 April to 4 May 2012. A comparative scholar who specialises in the field of comparative education in China, Prof Hayhoe delivered two lectures while here. A roundtable symposium was also organised in conjunction with her visit, where peers from Finland, Korea, Hong Kong, the United States, and colleagues from NIE engaged in dialogue about how their countries’ education systems continually innovate to stay on the top of their league
anti-Helicobacter Pylori Activity of Derivatives of the Phthalide-Containing Antibacterial Agents Spirolaxane Methyl Ether, CJ-12,954, CJ-13,013, CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015
No full textThe naturally occurring phthalide-containing antibiotics spirolaxine methyl ether, CJ-12,954, CJ-13,013, CJ-13,015, CJ-13,102, CJ-13,103, CJ-13,104 and CJ-13,108, have been reported to exhibit anti-H. pylori activity. However, the exact stereochemistry of spirolaxine methyl ether, CJ-12,954 or CJ-13,013, contributing to this observed activity has not been confirmed. The anti-H. pylori activity of several analogues of spirolaxine methyl ether, CJ-12,954 and CJ-13,013 of defined stereochemistry together with the anti-H. pylori activity of several indole analogues of the simpler phthalide-containing antibiotics CJ-13,102, CJ-13,104, CJ-13,108 and CJ-13,015 is reported herein. A 1:1 mixture of spiroacetals 5b and 6b in which the phthalide substituent exhibited (3R)-stereochemistry was sixty times more active than the corresponding 1:1 mixture of spiroacetals with (3S)-stereochemistry. Notably, the unnatural (2″S)-diastereomer of spirolaxine methyl ether exhibited more potent anti-H. pylori activity than the natural product spirolaxine methyl ether. The 4,6-dimethoxyindoles 9, 10, 11 and 13 were all found to be less active than their parent compounds 1, 2, 3 and 4, respectively. Chain-shortened 4,6-dimethoxyindole analogue 12 of CJ-13,108 3 and 4,6-dimethoxyindole-spiroacetal 13 exhibited weak anti-H. pylori activity thus providing future opportunity for drug discovery programs
Observation of psi(3686) -> e(+)e(-)chi(cJ) and chi(cJ) -> e(+)e(-)J/psi
No full textKolcu, Onur Buğra (Arel Author)Using 4.479 x 10(8) psi(3686) events collected with the BESIII detector, we search for the decays psi(3686) -> e(+)e(-)chi(cJ) and chi(cJ) -> e(+)e(-)J/psi, where J = 0, 1, 2. The decays psi(3686) -> e(+)e(-)chi(cJ) and chi(cJ) -> e(+)e(-)J/psi are observed for the first time. The measured branching fractions are B(psi(3686) -> e(+)e(-)chi(cJ)) = (11.7 +/- 2.5 +/- 1.0) x 10(-4), (8.6 +/- 0.3 +/- 0.6) x 10(-4), (6.9 +/- 0.5 +/- 0.6) x 10(-4) for J = 0, 1, 2, and B(chi(cJ) -> e(+)e(-)J/psi) = (1.51 +/- 0.30 +/- 0.13)x10(-4), (3.73 +/- 0.09 +/- 0.25)x10(-3), (2.48 +/- 0.08 +/- 0.16)x10(-3) for J = 0, 1, 2, respectively. The ratios of the branching fractions B(psi(3686) -> e(+)e(-)chi(cJ))/B(psi(3686) -> gamma chi(cJ)) and B(chi(cJ) -> e(+)e(-)J/psi)/B(chi(cJ) -> gamma J/psi) are also reported. Also, the alpha values of helicity angular distributions of the e(+)e(-) pair are determined for psi(3686) -> e(+)e(-)chi(c1,2) and chi(c1,2) -> e(+)e(-)J/psi
Synthesis of Indole Analogues of the Anti-Helicobacter pylori Compounds CJ-13,015, CJ-13,102, CJ-13,104 and CJ-13,108
No full textRacemic syntheses of indole analogues of four phthalide-containing anti-Helicobacter pylori agents CJ-13,015, CJ-13,102, CJ-13,104 and CJ-13,108 are reported via manipulation of a common intermediate. This intermediate was formed by the N-alkylation of 4,6-dimethoxyindole with a long chain bromide followed by further chain extension. Oxidation, acetylation, or Barton–McCombie deoxygenation of the intermediate followed by Wacker oxidation afforded three analogues whilst further reduction of one analogue afforded the final analogue
ON CJ- 1 - ON CJ-TOPLOGICAL SPACES
No full textIn this paper we introduced new types of spaces as CJ-space and strong CJ-space, also we studied the relationship between them and the relation of them with J-space and strong J-space researched by E.Michael
Asymptotic Stability of a Plane CJ Detonation Wave
No full text. We study the asymptotic stability of a plane CJ detonation wave under the assumption of small resolved heat release (SRHR). We prove that the solution exists globally and that the solution converges uniformly to a shifted CJ detonation wave as t!+ 1 for initial data which are small perturbations of the CJ detonation wave. The weighted energy method is used to overcome the difficulty arising from the sonic property at the end of the reaction. The SRHR model allows us to treat the non-monotone spike in the profile of the CJ detonation wave by the characteristic energy estimate. Key words. CJ detonation, shock wave, traveling wave, sonic point, asymptotic behavior, weighted energy estimate, characteristic energy estimate. AMS(MOS) subject classifications. 35L65, 35B40, 35B50, 76L05, 76J10. Acknowledgments. The author is grateful to Prof. T.-P. Liu for pointing out the reference of Matsumura and Nishihara to her. This work was partially supported by ONR N00014-92-J-1890. 1 Introduc..
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