1,720,993 research outputs found
Transanal resection of rectal lipoma mimicking rectal prolapse: description of a case and review of the literature
No full textSubmucosal lipomas of the large bowel are uncommon. Occasionally, they occur in the rectum and may cause aspecific symptoms; presentation with rectal prolapse is very unusual and may lead to a misdiagnosis of simple mucosal prolapse. The paper describes an additional case of a prolapsing rectal mass that led to diagnosis and surgical treatment of a rectal lipoma under local anesthesi
Il cancro colorettale: conoscenze, opinion ed adesione alla screening delle donne che si sottopongono a controllo senologico
No full textFactors influencing women partecipation in colorectal cancer screening
No full textColorectal cancer(CRC) is the 2nd most common cancer in
women worldwide. In Italy, only 50% of individuals invited touse Fecal occult blood test(FOBT) it attended. Women’s
participation for breast and cervical screening is very high.
More than 70% completed a mammography but the adhesion
to FOBT is lower than the other two screening offered for free
and the adhesion to colonoscopy is very low. The aim of the
study is investigate the beliefs, feelings and psychological
factors that could influence the behavior of women about
participation in cancer screening(Colonoscopy and FOBT).
Methods
The survey was carried out in a center for cancer prevention in
Siena, Tuscany, in 2011. A questionnaire, based on literature,
was administered to 507 women attending mammography or
clinical breast examination and it was administered to all age
women but adherence to colorectal cancer screening was
analyzed only for women age 50 years and older (207). We
performed descriptive and bivariate analysis and we examined
the association between participant characteristics, willingness
and adherence to screening.
Results
Family history of colorectal cancer is associated with adherence
to screening compliance (FOBT and colonoscopy)
(p < 0.0087).The doctor’s advice is significantly associated
with adherence to colorectal cancer screening (both)
(p < 0.0001). Women who perceived colonoscopy as a painful
examination are less likely to be compliant to screening for
CRC (colonoscopy) (p < 0.0002).The embarrassment is
another factor related to colonoscopy compliance (p < 0.0012).
Conclusions
Embarrassment, pain and doctor’s advice are the factors that
correlated more strongly with adherence (or not) to screening.
For the future is useful to implement information campaigns
on colorectal cancer and refresher courses for general
practitioners. A possible intervention for the future would be
to hand before mammography or gynecological examination
the kit for the collection of fecal occult blood
FAP associated cribriform morular variant of PTC: striking female prevalence and indolent course.
No full textA papillary thyroid carcinoma (PTC) is reported in 18 patients with FAP, all females.
The diagnosis was concomitant in 1/3, whereas in 1/3 FAP preceded and 1/3 was subsequent.
A cribiform morular variant (CMV) of PTC was present in 2 patients.
The germline APC mutation was detected in 16 out of 18: 5’ to codon 1220 in 14 and in codon 1309 in 2.
Even if CMV-PTC is associated with FAP in more than 50% of cases, not all FAP associated PTC show this variant.
FAP associated PTC occurs quite exclusively in females and has a good prognosis.
On the contrary, sporadic CMV-PTC often occurs in males and tends to have an aggressive behavior.
Therefore, caution is suggested before stating that, despite similar features, these tumors should be regarded as a single entity
elevata incidenza di carcinoma papillifero della tiroide in una famiglia con poliposi adenomatosa familiare
No full text
Microcystic adenoma of the pancreas (glycogen-rich cystadenoma) with stromal amyloid deposits
No full textWe report a case of a pancreatic glycogen-rich microcystic serous adenoma with stromal amyloid deposits, focusing on the significance of isolated amyloid deposits in tumours.
The architectural pattern was characterized by thin-walled cysts lined by a single layer of flat or cuboidal epithelial cells intensely stained by the PAS-reaction only before diastase digestion, suggesting the presence of glycogen. Tumour stroma was composed of broad fibrocollagenous tissue with lamellar hyalinized areas which were positively stained by Congo red and showed green birefringence and dichroism with polarized light. For amyloid protein characterization, immunohistochemical studies were performed with anti-beta amyloid protein and anti-amyloid precursor pre-A4695. The former antibody diffusely stained tumour stroma, while the latter stained only scattered stroma cells.
This is the first documented case of amyloid deposition in pancreatic serous adenoma. We indicate that the source of amyloid is an APP-like precursor secreted by stromal myofibroblasts
Diffuse cutaneous metastases as the only sign of extranodal tumor spread in a patient with adenocarcinoma of the colon
Full text linkCutaneous metastases from large bowel cancer are uncommon and are usually associated with organ involvement. Localization of lesions to the skin is mainly attributed to vascular and anatomical relationship, since most of them are seen in the abdominal wall or in a surgical scar. We report a 73-year-old woman in whom metastatic nodules from a poorly differentiated adenocarcinoma of the right colon developed throughout the skin (buttock, trunk, chest wall, arms, and neck) and remained the only sign of extranodal tumor spread until patient's death, seven months later. This unusual behaviour suggests that localization of neoplastic cells to the skin may be a site-specific process, determined by adhesion molecules and/or by growth factors found at that sit
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