196,038 research outputs found
Calcifications in prostate cancer: An active phenomenon mediated by epithelial cells with osteoblast-phenotype
No full textThe main aim of this study was to investigate putative correlation between the formation of prostate calcifications and the presence of cancer cells showing the ultrastructural and morphological aspects of osteoblasts. To this end, 40 prostate biopsies of prostate cancer were enrolled and investigated from histological, immunohistochemical, and ultrastructural point of view. To the best of our knowledge, this is the first study to propose a new cell type related to the ectopic calcifications in prostate tissue, the prostate osteoblast-like cells (POLCs). Although our data require further investigations about the molecular mechanisms of both POLCs Cells generation and calcification formation, this study can open new and interesting prospective in the management of prostate cancer patients. In fact, if our data will be validated in large-cohort studies, the presence of POLCs Cells and/or prostate calcifications could become a poor negative prognostic marker for cancer occurrence due to the correlation between the presence of POLCs Cells and epithelial to mesenchymal transition phenomenon
Comparative Response to Electroconvulsive Therapy in Medication-Resistant Bipolar I Patients With Depression and Mixed State
No full text
Risposta dimensionale al trattamento con aloperidolo e risperidone in pazienti psicotici acuti
No full textIntroduzione. Le teorie dimensionali sono alla base della farmacoterapia dimensionale: la pratica di scegliere le molecole antipsicotiche in base al profilo d’azione recettoriale che le rende efficaci su specifiche dimensioni psicopatologiche. Scopo. Esaminare i criteri clinici di scelta del trattamento, le dimensioni maggiormente rispondenti in pazienti psicotici acuti e l’efficacia di aloperidolo e risperidone nei confronti delle specifiche dimensioni. Materiali e metodi. Lo studio è stato condotto su 458 pazienti psicotici acuti, valutati con le scale PANSS e CGI ed è stata loro assegnata terapia con aloperidolo o risperidone. Sono stati valutati i criteri di scelta per il trattamento assegnato e le dimensioni considerate come maggiormente rispondenti. L’analisi fattoriale è stata utilizzata per individuare le componenti dimensionali del campione e per valutare l’efficacia delle molecole rispetto a esse. Risultati. Mentre risperidone viene scelto per le sintomatologie “positiva”, “negativa” e “depressiva”, aloperidolo viene scelto per le sintomatologie “positiva”, “disorganizzata” e per l’agitazione psicomotoria. L’analisi degli item della PANSS ha permesso di individuare quattro principali fattori dimensionali caratterizzanti il campione: “positivo”, “negativo”, “ansia/depressione”, “disorganizzazione”. Risperidone risulta superiore ad aloperidolo per le dimensioni “negativa”, “ansia/depressione”, “disorganizzazione”. Conclusioni. I criteri clinici di scelta del trattamento riflettono quanto è indicato in letteratura e l’efficacia delle molecole sulle specifiche dimensioni conferma la validità dei criteri di scelta.Introduction. The dimensional drug-therapy is based on dimensional theories, and consists in the practice of choosing the antipsychotic molecules according to the patients receptorial profile that makes them effective on specific psychopathological dimensions. Aim. To examine the clinical criteria of the treatment choice, the specific dimensions considered answer in acute psychotic patients and the effectiveness of haloperidol and risperidone relatively. Materials and methods. 458 acute psychotic patients were appraised with PANSS and CGI and were assigned to therapy with either haloperidol or risperidone.The criteria of choice for the treatment was appraised and the dimensions considered were evaluated. A factorial analysis was made in order to individualize the dimensional components characterizing the sample and to appraise the effectiveness of the molecules to their respect. Results. While risperidone is chosen for positive, negative and depressive symptomatology, haloperidol is chosen for positive and disorganized symptomatology, and for the psycho-motor agitation. The analysis of the PANSS items allowed us to individualize four main dimensional factors characterizing the sample: positive, negative, anxiety/depression, disorganization. Risperidone results superior in respect of haloperidol for the negative dimensions, anxiety/depression, disorganization. Conclusions. The clinical criteria of the treatment choice reflects what is indicated in literature, and the effectiveness of the molecules on the specific dimensions confirms the validity of the criteria of choice
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Studio del profilo premorboso circadiano del sonno e delle attività in pazienti affetti da disturbi depressivi
No full textCharacterisation oh harbour and coastal sediments: specific destinations of dredged material
No full textStudio del profilo premorboso circadiano del sonno e delle attività in pazienti affetti da disturbi depressivi
No full textObiettivo. I disturbi depressivi sono alterazioni del tono dell’umore nelle quali intervengono fattori biologici, psicologici, genetici, sociali e culturali. Diversi studi suggeriscono che anomalie a livello dei ritmi circadiani possano essere coinvolte in tali disturbi. Mentre appare certo che tali anomalie siano di estrema rilevanza in una fase acuta di malattia, più limitato sembra invece il numero di studi atti a indagare il profilo generale di attività circadiana in una fase premorbosa di patologia. Metodi. È stato esaminato un gruppo di 206 soggetti affetti da disturbi depressivi secondo il DSM-IV confrontati con un campione di 206 individui sani. Tutti i partecipanti hanno compilato un questionario, finalizzato a raccogliere informazioni sulle principali funzioni biologiche ritmiche. Le differenze a questo livello sono state confrontate utilizzando l’analisi statistica della varianza (ANOVA). Risultati. Nell’“Età Adolescenziale” si è riscontrato, a livello del sonno, un anticipo dell’ora di risveglio di circa 20 minuti nei soggetti depressi rispetto ai controlli. Nell’“Età Giovanile” emerge, invece, una differenza statisticamente significativa (p=0,02) nell’orario di risveglio dei soggetti affetti da un disturbo depressivo rispetto ai sani, risultando mediamente anticipato di 39 minuti. Conclusioni. Si può ipotizzare che alterazioni dei ritmi biologici circadiani concorrano alla genesi dei disturbi depressivi come fattori predisponenti o precipitanti. Potrebbero, inoltre, rappresentare uno strumento in grado di facilitare l’individuazione di soggetti caratterizzati da una particolare vulnerabilità per tali disturbi già in una fase premorbosa della patologia.Aim. Depressive disorders are mood alterations in which biological, psychological, genetic, social and cultural factors can play an important role. Many studies suggest that anomalies in circadian rhythms can be explored according to a general model of a chrono-biological implication in the pathogenesis of the disease. At present it is possible to see a general agreement in literature concerning the importance of such modifications in acute phase of depression. However, until now scarce is the number of studies that have the aim to explore the circadian activity in a premorbid phase of depressive disorder. Methods. 206 patients affected by DSM-IV Major Depressive Disorders are examined, compared to a group of 206 healthy subjects. All individuals included in this study were asked to complete a questionnaire about the time of awakening, falling asleep, maximum appetite, energy and mental focusing. Results from patients and healthy subjects were compared using the ANOVA test. Subjects in the “Adolescence” age group were found to have an increase in the time of awakening by approximately 20 minutes in the depressed subjects compared to the controls. In the study of “Youth” age group, the results showed a statistically significant difference (p<0,02) in the awakening time with an anticipation of about 39 minutes compared to healthy individuals. Conclusions. Our study allow hypothesizing that alterations of the biological circadian activity profile can contribute to the genesis of Depressive Disorders as predisposing factors. They could represent an important way to facilitate the identification of subjects already characterized by a particular vulnerability for depression in a premorbid phase of illness
Studio nell'Italia Centrale sull'uso degli antipsicotici atipici in SPDC. Risposta dimensionale al trattamento con aloperidolo e risperidone in pazienti psicotici acuti
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
- …
