1,720,963 research outputs found
Differential viral sensitivity to photoinactivation by haemoporphyrin and haematoporphyrin derivatives.
No full textCell fusion induced by herpes simplex virus is inhibited by hen egg-white lysozyme
No full textThe formation of syncytia in cell monolayers infected with a macroplaque strain (MP) of herpes simplex virus was found to be inhibited by hen egg-white lysozyme. Inhibition was roughly proportional to the enzyme concentration. The virus titres in supernatant fluids of lysozyme-treated cultures were also reduced compared with untreated cultures. Control experiments excluded the possibility that lysozyme altered the virus viability and infectivity or impaired cell growth. Since lysozyme is a cationic protein, further experiments were performed in order to discover whether its antisyncytiogenic effect depended on its enzymatic activity or on its positive charge. Inhibition of the MP-induced polycaryocytosis was found to be caused by heat-inactivated lysozyme and three chemically-modified lysozymes with a higher positive charge (one retaining and two lacking enzymatic activity)
DIFFERENTIAL VIRAL SENSITIVITY TO PHOTOINACTIVATION BY HAEMATOPORPHYRIN AND HAEMATOPORPHYRIN DERIVATIVE
No full textEtude de l'influence de l'haematoporphyrine (HP) et des dérivés de
l'haematoporphyrine (HPD) sur la sensibilité virale à la photoinactivation. HPD a une action
plus efficace sur l'inactivation virale un spectre d'action plus large et agit particulièrement sur
le virus de la vaccine. Le fait que l'enveloppe virale puisse être une cible préférentielle pour
les processus d'oxydation photodynamiques est discute
Simplified lyogroup system, a new method for routine identification of staphylococci: description and comparison with three other methods
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Inhibition of Herpes simplex virus-induced cytopathic effect by modified hen egg white lysozyme
No full textHen egg-white lysozyme and three of its basic derivatives obtained by chemical modification were tested for their activity in vitro against a wild strain of herpes simplex virus type 1. Marked inhibition of the cytopathic effect was exhibited by the three chemical derivatives and the heat-inactivated lysozyme, whereas the native enzyme displayed only modest anticytopathic activity. Enzymatic activity did not appear to be necessary for the antiherpes activity of the lysozyme compounds. Instead, other properties such as their basic nature seemed to be relevant to their antiherpes effectiveness in vitro. At the concentrations used, all compounds but one had no significant effect on cell viability and growth. Some of the compounds tested caused formation of deposits on the surface of the cells. Some correlation between deposit formation and antiherpes cytopathic activity was found. The antiherpes efficacy in vitro and toxicity of the modified lysozymes were compared with those of known antiviral agents. The lysozymes were less toxic than the reference antiviral agents, and some of them were also more activ
Kinectics of Herpes simplex virus photoinhibition by haemtoporphyrin in both diploid and heteroploid cells.
No full textInhibition of herpes simplex virus-induced cytopathic effect by modified hen egg-white lysozyme.
No full textRoutine separation of staphylococci from micrococci based on bacteriolytic activity production
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