1,721,033 research outputs found
Recurrent inflammatory myofibroblastic tumor of the glottis mimicking malignancy
No full text[No abstract available
Otorhinolaryngological aspects of HIV infections: personal experience.
No full textThe involvement of the ENT sphere in HIV infections is fairly common, but the relative manifestations, though not to be considered atypical, are not pathognomonic. The present study has been set up for the otoiatric assessment of a group of HIV patients and the correlation of ENT symptoms with the various stages of the disease. To this end, 60 patients were examined (35 belonged to groups 2-3 and 25 to group 4) of whom 50% were drug addicts, 36% homosexuals and 14% heterosexuals. All patients underwent a complete ENT examination as well as the assessment of hearing and vestibular function, of olfactory and taste functions, of respiratory and nasal mucociliary functions along with an anti-HIV antibody check of nasal secretion. Results showed a prevalence of otologic and rhinosinusal symptoms as well as cervical-facial swelling. Testing revealed a hearing loss of mainly conductive origin caused by otitis and tubal stenosis; vestibular hyporeflexia; mixed hyposmia and hypogeusia owing to the involvement of multiple cranial nerves; respiratory and mucociliary changes due to rhinitis and hypertrophy of the nasal mucosa. In all cases anti-HIV antibodies were found in nasal secretion. From a diagnostic point of view there was a prevalence of specific pathologies: oropharyngeal candidosis, stage 4; cervical lymphoadenopathy, stages 2-3; chronic rhinosinusitis, nasal vestibulitis and nosebleed; mainly chronic otitis media. All such manifestations suggest a marked involvement of ENT organs, which can be attributed to the anatomical characteristics of the area, with the relative diagnostic and prognostic implications of HIV infection
Local treatment of nasal polyposis with capsaicin: Preliminary findings
No full textThe inflammatory process triggered by the nasal hyperreactivity, whether specific or aspecific, presents three components: immunomediation - neurogenic - interconnection between the nervous and the immunitary systems. Neuropeptides (eg SP and CGRP) are among the agents responsible for neurogenic phlogosis and, in our opinion, they contribute towards the onset of polyps. Capsaicin, which acts on the C fibres, has been applied locally (30 μm) by the AA in 15 patients affected by aspecific nasal hyperreactivity with polyps, in the course of a double blind study with an equal number of patients. Treatment was given once a week for 5 consecutive weeks in order to evaluate the effect on both the hyperreactivity and the polyps. Before and after each session and at the 1- and 3-month controls the following tests were carried out: assessment of symptoms, nasal endoscopy, sizing of the polyps, aspecific nasal provocation test and nasal cytology. Apart from an improvement in symptoms and in nasal hyperreactivity, results showed a reduction in the size of the polyps even though accompanied by a gradual increase of eosinophiles which was not correlated to a degranulation process
Horizontal glottectomy according to Calearo-Teatini for the treatment of tumors involving the anterior commissure of the larynx: oncological and functional results
No full textAlterations of the Olfactory-Gustatory Functions in Patients with Eating Disorders
No full textObjective The purpose of this study was to assess olfactory-gustatory function impairment in patients with eating disorders. Methods Nineteen patients with a diagnosis of bulimia nervosa, 18 patients with a diagnosis of anorexia nervosa and a control sample of 19 healthy subjects were recruited from the day hospital service of the Complex Operative Unit for Alimentary Conduct Disorders of the Policlinico Umberto I in Rome. Evaluation of olfactory and gustatory functions was performed on patients through the Sniffin' Sticks' method in order to assess the olfactory threshold, the capacity for discriminating and identifying olfactory stimuli, and the overall olfactory function, and through the taste strip' kit method in order to assess the gustatory function. The results were processed statistically to assess differences between patients with anorexia nervosa, patients with bulimia nervosa and healthy controls. Results The two groups of patients with bulimia nervosa and anorexia nervosa showed a poorer olfactory and gustatory function compared with the healthy controls; discrimination of olfactory stimuli and overall olfactory function were reduced in both samples, as well as the overall gustatory function and the perception of bitter stimuli, whereas olfactory threshold was altered only in patients with bulimia nervosa. In both samples, scores for olfactory function fell within the range of hyposmia. Discussion Our data suggest that patients with eating disorders have an altered perception of olfactory and gustatory stimuli. The alterations observed are worth further investigation. Copyright (c) 2013 John Wiley & Sons, Ltd and Eating Disorders Association
L'ipoplasia del seno mascellare: trattamento per via endoscopica. Descrizione di due casi clinici e revisione della letteratura
No full textNon-specific hyperreactivity before and after nasal specific immunotherapy
No full textBackground: specific local immunotherapy (SLIT) improves symptom scores for allergic rhinitis during treatment and after its conclusion, as confirmed by non-specific tests. However, the duration of clinical and instrumental improvement after discontinuing SLIT is unknown. Objective: to evaluate the changes in the non-specific reaction time of patients with allergy to Dermatophagoides pteronissinus before and during 3 years of SLIT, and 6, 12, 18, and 24 months after discontinuing SLIT. Material and methods: sixteen patients were diagnosed by clinical history, positive skin test for D. pteronissinus, RAST, nasal provocation test (NPT) specific for D. pteronissinus, NPT with cold water solution. SLIT was administered by nasal spray. Patients were evaluated before, at 6, 12, 24, and 36 months of SLIT, and 6, 12, and 18 months after discontinuing SLIT. At the beginning of SLIT, the allergen concentration used was similar to that used in NPT. Maintenance doses were administered 3 times a week for 1 year and 2 times a week for 2 years. All patients kept a symptom diary. Results: after the first year of SLIT, total nasal resistance (TNR) decreased sharply. TNR then remained constant at the end of the second year and decreased at the end of the third year of treatment. Discontinuation of SLIT did not produce evident variations in average TNR at 6 or 12 months, but 3/16 patients at 6 months and 9/16 patients at 12 months complained of symptomatic deterioration. The most evident deterioration was noted at the 18-month post-SLIT visit, in which TNR values were similar to those recorded at the onset of treatment. Positive response to stimulation and increased TNR were found after SLIT in 8/16 patients at 6 months, 13/16 at 12 months, 12/13 at 18 months, and 7/7 at 24 months. The symptom score indicated the return of symptoms. Twelve months after discontinuing SLIT, the patients complained about increased secretion and itching. The initial non-specific hyperreactivity, which had been present in all patients, was not evident in 68.7% after 3 years of SLIT, but persisted in a milder form in 31.3%. Conclusion: SLIT successfully reduced symptoms of D. pteronissinus sensitivity. Non-specific hyperreactivity was absent at the end of SLIT, but returned by 6 months after discontinuing SLIT. Therefore, SLIT did not maintain the clinical results achieved at the beginning of treatment for more than 12 months
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