6,665 research outputs found
Large-scale hormone replacement therapy and life expectancy: results from an international comparison among European and North American populations.
No full textA high-monounsaturated-fat/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients.
No full textA high-monounsaturated-fat/low-carbohydrate diet improves peripheral insulin sensitivity in non-insulin-dependent diabetic patients.
No full textDoes a high-carbohydrate diet have different effects in NIDDM patients treated with diet alone or hypoglycemic drugs?
No full textLarge-scale hormone replacement therapy and life expectancy: results from an international comparison among European and North American populations.
No full textEffectiveness and safety of carotid endarterectomy under remifentanil.
No full textAIM: The aim of this study was to evaluate the effectiveness and safety of carotid endarterectomy (CEA) with conscious sedation under remifentanil (Remifentanil anesthesia - RA) vs conventional loco-regional anesthesia (Conventional-LRA) in the current practice of a vascular surgery unit.METHODS: We introduced the ''Remifentanil-RA'' in our practice according to a two-step protocol. In the first step we performed a pilot prospective study to assess the procedure's safety and reproducibility in our setting on 60 consecutive patients with symptomatic and/or high-grade (>70%) internal carotid artery stenosis and alternately assigning them either to ''Remifentanil-RA'' or ''Conventional-LRA'' CEA. In the second step we analysed our routine operative records as to effectiveness and safety on 533 patients who consecutively underwent ''Remifentanil-RA'' CEA. We compared them with 533 age- and sex-matched historical controls who underwent ''Conventional-LRA'' CEA.RESULTS: The patients' mean age was 71.2+/-6.8 vs 71.8+/-6.1 (''Remifentanil-RA'' vs ''Conventional-LRA''). About 73% of them were male and 56% had a symptomatic carotid stenosis. Neither the pilot study nor second step comparison showed differences in outcome measures. We found only higher peri-operative nausea/ vomit (3.6% vs 0.4% ''Remifentanil-RA'' vs ''Conventional-LRA'', P<0.0002) and fewer re-operations for post-operative hematomas (3% vs 5.4% respectively, P=0.048).CONCLUSIONS: We found that ''Remifentanil-RA'' CEA was safe, effective and satisfactory. Nevertheless, with the potential problems of intubation and those already found with side effects, a randomized control trial (RCT) is needed in order to prove that this method is superior to ''Conventional-LRA'' CEA.Aim. The aim of this study was to evaluate the effectiveness and safety of carotid endarterectomy (CEA) with conscious sedation under remifentanil (Remifentanil anesthesia - RA) vs conventional loco-regional anesthesia (Conventional-LRA) in the current practice of a vascular surgery unit. Methods. We introduced the "Remifentanil-RA" in our practice according to a two-step protocol. In the first step we performed a pilot prospective study to assess the procedure's safety and reproducibility in our setting on 60 consecutive patients with symptomatic and/or high-grade (>70%) internal carotid artery stenosis and alternately assigning them either to "Remifentanil-RA" or "Conventional-LRA" CEA. In the second step we analysed our routine operative records as to effectiveness and safety on 533 patients who consecutively underwent "Remifentanil-RA" CEA. We compared them with 533 age- and sex-matched historical controls who underwent "Conventional-LRA" CEA. Results. The patients' mean age was 71.2±6.8 vs 71.8±6.1 ("Remifentanil-RA" vs "Conventional-LRA"). About 73% of them were male and 56% had a symptomatic carotid stenosis. Neither the pilot study nor second step comparison showed differences in outcome measures. We found only higher peri-operative nausea/ vomit (3.6% vs 0.4% "Remifentanil-RA" vs "Conventional-LRA", P<0.0002) and fewer re-operations for post-operative hematomas (3% vs 5.4% respectively, P=0.048). Conclusion. We found that "Remifentanil-RA" CEA was safe, effective and satisfactory. Nevertheless, with the potential problems of intubation and those already found with side effects, a randomized control trial (RCT) is needed in order to prove that this method is superior to "Conventional-LRA" CEA
High endogenous estradiol is associated with increased venous distensibility and clinical evidence of varicose veins in menopausal women.
No full textMenstrual cycle length, serum lipids and lipoproteins in a cohort of Italian Mediterranean women: findings from Progetto ATENA
No full textHigh endogenous estradiol is associated with increased venous distensibility and clinical evidence of varicose veins in menopausal women.
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