1,721,018 research outputs found
Memory span for movement configurations: The effects of concurrent verbal, motor and visual interference
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Strain-dependent effects of post-training cocaine or nomifensine on memory storage involve both D1 and D2 dopamine receptors.
No full textPost-training administration of cocaine (1-10 mg/kg) or nomifensine (1-10 mg/kg) dose-dependently improves retention of an inhibitory avoidance response in C57BL16 mice, while impairign it in the DBA/2 strain. The effects of retention performance induced by the psychostimulant and the dopamine (DA) reuptake blocker in C57BL/6 and DBA/2 mice appear to be due to an effect on memory consolidation. In fact, they were observed when drugs were given at short, but not long, periods of time after training, i.e. when the memory trace is susceptible to modulation. Moreover, these effects are not to be ascribed to an aversive or a rewarding or non-specific action of the drugs on retention performance, as the latencies during the retention test of those mice that had not received a footshock during the training were not affected by the post-training drug administration. The strain-dependent effects of an intermediate dose (5 mg/kg) of both cocaine and nomifensine were reversed by pretreatment with either selective D1 or D2 DA receptor antagonist SCH 23390 and (-)-sulpiride administered at per se non-effective doses (0.025 and 6 mg/kg, respectively), thus suggesting that D1 and D2 receptor types are similarly involved in modulating memory processes. These results show that the effects of cocaine on memory consolidation are related to to its dopaminergic action, since they are similar to those produced by nomifensine and, what is more important, are antagonized by pretreatment with DA receptor antagonists.(ABSTRACT TRUNCATED AT 250 WORDS
Interaction between NMDA competitive antagonist CPP and the dopaminergic system in the modulation of memory processes
No full textThe MAP(K) of fear: From memory consolidation to memory extinction
No full textThe highly conserved mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade is involved in several intracellular processes ranging from cell differentiation to proliferation, as well as in synaptic plasticity. In the last two decades, the role of MAPK/ERK in long-term memory formation in mammals, particularly in fear-related memories, has been extensively investigated. In this review we describe knowledge advancement on the role of MAPK/ERK in orchestrating the intracellular processes that lead to the consolidation, reconsolidation and extinction of fear memories. In doing so, we report studies in which the specific role of MAP/ERK in switching from memory formation to memory erasure has been suggested. The possibility to target MAPK/ERK in developing and/or refining pharmacological approaches to treat psychiatric disorders in which fear regulation is defective has also been envisaged. © 2013 Elsevier Inc. All rights reserved
STRAIN-DEPENDENT EFFECTS OF POST-TRAINING GABA RECEPTOR AGONISTS AND ANTAGONISTS ON MEMORY STORAGE IN MICE
No full textPost-training administration of the GABA-A and GABA-B receptor agonists muscimol and baclofen dose-dependently impaired retention of an inhibitory avoidance response in C57 mice, while improving memory consolidation in the DBA strain. By contrast, picrotoxin (blocker of GABA-activated ionophores), bicuculline (GABA-A antagonist) and CGP 35348 (GABA-B antagonist) dose-dependently improved retention in C57 mice and impaired it in DBA mice. These effects cannot be ascribed to non-specific actions of the drugs on retention performance, as the latencies during the retention test of those mice that had not received footshock during the training were not lengthened by the post-training drug administration. The effects on retention performance induced by GABA agonists and antagonists are probably due to an effect on memory consolidation, since they are observed when the drugs are given at short, but not at long, intervals after training. These results are discussed in terms of possible interaction of GABA systems with endogenous opioid and dopamine systems, whose activation has been shown to produce strain-dependent effects on memory processes. The possible utilization of these results for a genetic behavioral approach with recombinant inbred (RI) mice is also considered
STRAIN-DEPENDENT EFFECTS OF POST-TRAINING DOPAMINE RECEPTOR AGONISTS AND ANTAGONISTS ON MEMORY STORAGE IN MICE
No full textPost-training administration of the selective D1 or D2 agonists SKF 38393 and LY 171555 dose dependently impairs retention of an inhibitory avoidance response in DBA/2 mice. In agreement, the selective D1 or D2 antagonists SCH 23390 and (-)-sulpiride improve retention. These effects are opposite to those observed in the C57BL/6 strain, as previously reported. Moreover, B6D2F1 hybrids present a response to SKF 38393, LY 171555, SCH 23390, and (- )-sulpiride that parallels that of the C57BL/6 strain, thus suggesting that the neural mechanisms underlying the effects of DA agonists or antagonists on memory processes may be inherited through a dominant mode of inheritance
The effects of morphine on memory consolidation in mice involve both D1 and D2 dopamine receptors.
No full textPost-training administration of morphine (0.25, 0.5, or 1 mg/kg) dose-dependently impairs retention of an inhibitory avoidance response in mice. The effects on retention performance induced by the drug appear to be due to an effect on memory consolidation. In fact, they were observed when drugs were given at short, but not long, periods of time after training, i.e., when the memory trace was susceptible to modulation. Moreover, these effects are not to be ascribed to an aversive or a rewarding or nonspecific action of the drugs on retention performance, because the latencies during the retention test of those mice that had not received a footshock during the training were not affected by post-training drug administration. Pretreatment with either selective D1 or D2 dopamine (DA) receptor antagonists SCH 23390 and (-)-sulpiride administered at per se noneffective doses (0.025 and 6 mg/kg, respectively) potentiated the effects of morphine, while either selective D1 or D2 receptor agonists SKF 38393 and LY 171555 at per se noneffective doses (5 and 0.25 mg/kg, respectively) antagonized the effects of the opiate on memory consolidation. No significant differences were evident between the effects of D1 and D2 receptor active compounds, thus suggesting that D1 and D2 receptor types are similarly involved in the effects of morphine on memory consolidation, in agreement with previously reported results. These results are discussed in terms of a possible inverse relationship of endogenous opioid and DA systems in the brain that are involved in memory processes
Memory for object location: A span study in children
Full text linkThe aim of the present study was to analyze the developmental changes in three spatial processes, namely, in positional reconstruction involving the retention of spatial locations per se (Positional encoding task), in the assignment of objects to positions (Object-to-position assignment task), and in the integration of these two (Combined task). A span procedure was used to assess the development of spatial memory in children aged 6, 8, and 10 years tested in these three tasks. The findings of the present study provide developmental spans for each relocation task. Results show an age-dependent improvement in all tasks, suggesting that spatial position is not automatically encoded. The results also show different developmental patterns for the relocation tasks considered, Suggesting that spatial memory comprises a number of different component processes
The relationship between divided attention and implicit memory: A meta-analysis
Full text linkThis article reports a meta-analysis comparing the size of repetition priming in full and divided-attention (DA) conditions. The main analysis included 38 effect sizes (ES) extracted from 21 empirical studies, for a total of 2074 (full-attention) and 2148 (divided-attention) participants. The mean weighted ES was 0.357(95% CI=0278-0.435), indicating that divided attention produced a small, but significant, negative effect on implicit memory. Overall, the distinction between identification and production priming provided the best fit to empirical data (with the effect of DA being greater for production tests), whereas there was no significant difference between perceptual and conceptual priming. A series of focused contrasts suggested that word-stem completion might be influenced by lexical-conceptual processes, and that perceptual identification might involve a productive component. Implications for current theories of implicit memory are discussed. (C) 2010 Elsevier B.V. All rights reserved
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