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    STUDIES ON ANTICANDIDA AGENTS WITH A PYRROLE MOIETY - SYNTHESIS AND MICROBIOLOGICAL ACTIVITY OF SOME [(1-ALKYL),(1-ARYL) AND (1-BENZYL)-5-ARYL-3-CARBOXAMIDO-2-METHYL]PYRROLE DERIVATIVES

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    The synthesis of some [(1-alkyl), (1-aryl) and (1-benzyl)-5-aryl-3-carboxamido-2-metyl]pyrrole derivatives is reported. Their activity against Candida strains has been assessed and the structure-activity relationships for these compounds are discussed

    A 1,5-DIARYLPYRROLE DERIVATIVE

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    The structure of the 1,5-diarylpyrrole derivative, ethyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-2-methyl-3-pyrrolecarboxylate, C20H16Cl3NO2, has been determined. The orientation assumed by the phenyl rings corresponds to the deepest of the two minima obtained from ab initio calculations. All bond distances and angles are in the expected ranges
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