1,721,085 research outputs found
Nanosized delivery systems for therapeutic proteins and drugs via multifunctional (co)polymer engineering
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Chitosan/β-glycerophosphate-based microparticles manufactured by laminar jet break-up technology
No full textThis study is about the use of β-glycerophosphate (βGP) to modulate the production of chitosan microparticles through a technology of jet break-up. βGP has been described as capable of producing chitosan gels without additional complexing agents via a thermal transition (inverse gelation). A preliminary assessment on the effect of temperature on the viscosity and gelation of chitosan/βGP precursors demonstrated that the crosslinking process was too slow to afford microparticle production via jet break-up. Instead, βGP was used as a solubilizer to provide stable chitosan solution at neutral pH, which allowed the preparation of microparticles through polyelectrolyte complexation (with triphosphate) under physiological conditions, as opposed to the more conventional method of chitosan solubilisation in acids. Here, the key parameters of the microencapsulation process have been optimized, aiming to produce spherical particle of well-defined size and circularity, as well as toroidal microparticles, with a physico-chemical evaluation of the products
PROGETTAZIONE DI MACROMOLECOLE AD ARCHITETTURA COMPLESSA PER LA NANOMEDICINA
No full textPolimeri ad architettura complessa vengono sempre più utilizzati in nanomedicina, grazie alla loro capacità di attraversare barriere biologiche e di trasportare farmaci. Polimerizzazioni controllate e tecniche di “click chemistry” permettono una sintesi di macromolecole biocompatibili con peso molecolare, topologia e funzionalità regolabili
Complex polymeric architectures self-assembling in unimolecular micelles: Preparation, characterization and drug nanoencapsulation
Full text linkUnimolecular polymeric micelles are a class of single-molecule amphiphilic core-shell polymeric architectures, where the hydrophobic core is well stabilized by the hydrophilic shell, avoiding intermolecular core-core interactions. Multi-arm copolymers with a dendritic core, as well as hyperbranched and comb-like polymers, can form unimolecular micelles easily. In this review, examples of polymers able to form detectable unimolecular micelles will be presented, summarizing the analytical techniques used to characterize the unimolecular micelles and discriminate them from other supramolecular aggregates, such as multi-micelle aggregates. Unimolecular micelles are suitable for the nanoencapsulation of guest molecules. Compared to traditional supramolecular micelles, unimolecular micelles do not disassemble under dilution and are stable to environmental modifications. Recent examples of their application as drug delivery systems, endowed with increased stability and transport properties, will be discussed
Tailoring Functional Copolymer Interactions for Efficient Nanotherapeutic Delivery: A novel Design by-Architecture Approach
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