1,721,257 research outputs found
Can we distinguish clinically hibernation from stunning and does it matter?
No full textCan we distinguish clinically hibernation from stunning and does it matter
One heart, two lungs together forever
No full textReview of the complex interrelationship between cardiovascular disease (and in particular chronic heart failure) and pulmonary disease (and in particular chronic obstructive pulmonary disease).
Common risk factors, diagnostic challanges and therapeutic difficulties are discusse
INIBIZIONE SELETTIVA E SPECIFICA DEI CANALI IF CON UNA NUOVA MOLECOLA PER LA TERAPIA DELLE MALATTIE CARDIOVASCOLARI / SELECTIVE AND SPECIFIC IF INHIBITION WITH NEW MOLECULE: NEW PERSPECTIVES FOR THE TREATMENT OF CARDIOVASCULAR DISEASE
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Neurohormonal modulation and cardiorenal axis-relevance in heart failure management
No full textNeurohormonal modulation and cardiorenal axis-relevance in heart failure managemen
Neuroendocrine activation in left ventricular dysfunction
No full textNeuroendocrine activation in left ventricular dysfunctio
Future strategies of reverse remodeling prevention of hibernation
No full textA complex interrelationship exists among chronic ischemic left ventricular dysfunction, persistence of myocardial viability and possibility to limit progression of chronic heart failure. Cardiac remodeling is influenced by several factors still under investigation. Hibernation is basically an adaptive mechanism
to chronically abnormal coronary blood flow, characterized by metabolic and structural alterations of the cardiac tissue, that are fully recovered upon revascularization. The estimate of the prevalence of myocardial viability in patients with chronic ischemic left ventricular dysfunction is crucial and different figures can be obtained by applying different diagnostic techniques and
analyzing different cohorts of patients. In patients with chronic heart failure and substantial areas of myocardial ischemia and viability, revascularization is likely to prolong survival. The amount of viable myocardium needed to be clinically relevant remains to be established: only randomized prospective studies, focusing on both functional improvement and prognosis, will give an evidence-based conclusion. An aggressive and thoughtful surgical approach to patients with ischemic heart failure can yield satisfying long-term results, with survival rates superior to medical management alone, and can constitute a true and valid alternative to heart transplantation
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