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TRANSCRIPTION FACTOR TBX1 OVEREXPRESSION INDUCES DOWNREGULATION OF PROTEINS INVOLVED IN RETINOIC ACID METABOLISM: A COMPARATIVE PROTEOMIC ANALYSIS
No full textTranscription factor TBX1 overexpression induces downregulation of proteins
involved in retinoic acid metabolism: a comparative proteomic analysis.
Caterino M, Ruoppolo M, Fulcoli G, Huynth T, Orrù S, Baldini A, Salvatore F.
CEINGE Biotecnologie Avanzate scarl, Napoli, Italy, Dipartimento di Biochimica e
Biotecnologie Mediche, Universita di Napoli Federico II, Napoli, Italy.
TBX1 haploinsufficiency is considered a major contributor to the
del22q11.2/DiGeorge syndrome (DGS) phenotype. We have used proteomic tools to
look at all the major proteins involved in the TBX1-mediated pathways in an
attempt to better understand the molecular interactions instrumental to its
cellular functions. We found more than 90 proteins that could be targeted by TBX1
through different mechanisms. The most interesting observation is that
overexpression of TBX1 results in down-regulation of two proteins involved in
retinoic acid metabolism
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