199,096 research outputs found

    Erratum to: The Role of Adipocytokines in Coronary Atherosclerosis (Current Atherosclerosis Reports, (2017), 19, 2, (10), 10.1007/s11883-017-0644-3)

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    Concerning the paper entitled, “The role of adipocytokine in coronary atherosclerosis” the author to be corrected is Casula Matteo. The correct form is Matteo Casula. Matteo is the first name whereas Casula is the family name

    Rassegna trimestrale dell’Osservatorio AIR

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    Editors: Mattia Casula e Fabrizio Di Mascio. Comitato scientifico: Claudio M. Radaelli (Presidente), Alberto Alemanno, Lorenzo Allio, Peter Biegelbauer, Federica Cacciatore, Edoardo Chiti, Fabrizio De Francesco, Fabrizio Di Mascio, Valerio Di Porto, Efisio Espa, Oliver Fritsch, Elizabeth Golberg, Antonio La Spina, Alessandro Natalini, Patricia Popelier, Nicoletta Rangone, Siriana Salvi, Francesco Sarpi, Lorna Schrefler, Miroslava Sholten, Ilde Rizzo, Giulio Vesperini, Helen Xanthaki, Davide Zaottini Comitato di redazione: Federica Cacciatore, Alessandro Natalini, Carolina Raiola (Responsabile editoriale e Art director), Siriana Salvi, Francesco Sarpi, Giulio Vesperini

    Adherence to lipid-lowering treatment : the patient perspective

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    Despite the widespread prescription of highly effective lipid-lowering medications, such as the HMG-CoA reductase inhibitors (statins), a large portion of the population has lipid levels higher than the recommended goals. Treatment failures have been attributed to a variety of causes but the most important is likely to be poor adherence to therapy in the form of irregular or interrupted intake and the high frequency of discontinuation or lack of persistence. Adherence is a multidimensional phenomenon determined by the interplay of patient factors, physician factors, and health care system factors. Patients' knowledge and beliefs about their illness, motivation to manage it, confidence in their ability to engage in illness-management behaviors, and expectations regarding the outcome of treatment and the consequences of poor adherence interact to influence adherence behavior. Patient-related factors account for the largest incremental explanatory power in predicting adherence. This article provides an overview of this critical issue, focusing on patient role in determining adherence level to lipid-lowering therapy. © 2012 Casula et al, publisher and licensee Dove Medical Press Ltd

    Who governs in (local) governance? Theoretical considerations and empirical evidence

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    Abstract This article aims to discuss the possible actors that can determine public policies, and the influence of new decisional arenas on politics. This theoretical work presents the evolution of different models of producing public policies, to the transformations taking place with the adoption of the governance model. Using empirical evidence from the Italian case, the study of new decisional arenas for the determination of public policies shows that there are still several problems to be addressed. Such problems are connected, above all, with the uncertain democratic nature of these arenas, as well as with the impossibility to clearly attribute political responsibility to the choices adopted in these spaces. These are issues and future research questions to be resolved, limiting the analysis to specific case studies, preferably related to the local sphere.</jats:p

    Motion estimation and CABAC VLSI co-processors for real-time high-quality H.264/AVC video coding

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    Real-time and high-quality video coding is gaining a wide interest in the research and industrial community for different applications. H.264/AVC, a recent standard for high performance video coding, can be successfully exploited in several scenarios including digital video broadcasting, high-definition TV and DVD-based systems, which require to sustain up to tens of Mbits/s. To that purpose this paper proposes optimized architectures for H.264/AVC most critical tasks, Motion estimation and context adaptive binary arithmetic coding. Post synthesis results on sub-micron CMOS standard-cells technologies show that the proposed architectures can actually process in real-time 720 × 480 video sequences at 30 frames/s and grant more than 50 Mbits/s. The achieved circuit complexity and power consumption budgets are suitable for their integration in complex VLSI multimedia systems based either on AHB bus centric on-chip communication system or on novel Network-on-Chip (NoC) infrastructures for MPSoC (Multi-Processor System on Chip

    Between national constraints and the legacies of the past: explaining variations in inter-municipal cooperation in Italian regions

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    Despite the historical tradition of inter-municipal cooperation in several regions, the Italian policy maker has for the first time decided to oblige small municipalities to co-manage their basic functions. Although controversial because of its overly top-down logic, this provision is driving a “new” era of inter-municipal cooperation in Italian regions: around 70% of Italian municipalities must choose between a municipal union and a covenant in order to manage these functions. Regions can direct their municipalities towards different forms of inter-municipal cooperation with the use of monetary incentives, regulatory restrictions or persuasion. The paper develops an analytic framework to explore this process in two regional cases. The analysis highlights that despite the national constraints, the different regional strategies are increasingly conditioned by the legacies of the past

    Adapation or Transformation? Interpreting Participation in Times of Austerity in an Old Red Region

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    This article investigates how political, social and associative participation is changing in the last years in an old Italian "red" region (Emilia-Romagna) with respect the previous decades. The analysis of the new model of participation that is increasingly consolidating in the selected case shows that a process of adaptation, rather than transformation, is taking place. In fact, the actual economic crisis is only accentuating the establishment of this new model, which continues to a large extent to be conditioned by the civic-mindedness historically present in this region, and which has been subject of several studies in the past by Italian and American scholars.<br /

    Implementing the transformative innovation policy in the European Union: how does transformative change occur in Member States?

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    Despite the emerging theoretical importance of the ‘transformative change’ approach, relatively little is known about how transition towards this approach is happening in different European contexts, as well as the institutional factors that help explain possible different reform trajectories. To fill this research gap, this article interprets the adoption of the ‘transformative change’ approach in Europe as a paradigmatic case of multi-level policy implementation in the European Union. Taking advantage of an institutional approach drawing on path dependency, it considers how transformative change is happening in two Member States (France and Germany). It does so by focusing on the policy mix adopted to address grand challenges and the type of governance mechanisms mainly used to secure legitimization and coordination. Albeit within the same EU framework, this article shows a diverse development of the innovation policies in the two Member States with the use of a different mix of policy instruments in line with their traditional domestic institutional contexts. Institutional contexts also filtered the early stages of the responses to the COVID-19 crisis. These results have specific implications useful for policy makers and practitioners in the design and implementation of regional innovation policies across different European contexts

    Under which conditions is Cohesion Policy effective: proposing an Hirschmanian approach to EU structural funds

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    Under which conditions is EU Cohesion Policy effective? Which are those ‘conditioning factors’ that help in explaining where, when, and how the Cohesion Policy is effective? This article adopts an Hirschmanian approach to argue that that the institutional characteristics of domestic authorities involved in the management of funds, as well as the decisions of policy makers, represent the key factors for understanding the effects of the Cohesion Policy in European regions. By using Cohesion Policy implementation in Italy and Spain as a pilot study, this article empirically investigates the interaction of three different types of factors (institutional, strategic [related to the types of investments made], and administrative), and elaborates an original framework for comparing different Cohesion Policy implementations, and existing studies analyzing the impact of the Cohesion Policy. The framework presented in this article could be extended to other European countries by political scientists who are interested in studying the Cohesion Policy as a case of development policy

    Centralizing cohesion policy in times of austerity: evidence from the policy cycle

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    European policy-making has been interpreted as a pendulum that swings between the Member States (MSs) and the transnational arena when choices about where to assign policy responsibilities have to be made. As in other policy sectors, the pendulum metaphor has been used to interpret the changes which have occurred in Cohesion Policy supremacy. This article analyses how the attribution of responsibilities between the European Commission (EC), and the MSs has changed in the different phases of the policy cycle since the 1988 reform to the present day, simultaneously with the main stages of the European integration process. The main argument is that the 2008 Global Financial Crisis was a critical juncture within the history of the aforementioned integration process because it opened the way for the pursuit of new paths: it favoured the consolidation of a new governance system that pivots on the EC’s active role, by identifying Cohesion Policy as the main instrument to pursue the Europe 2020 objectives. Accordingly, this article provides interpretative keys with which to explain the changes that have occurred in intergovernmental relations since the 1988 reform, as well as analytical tools with which to understand the ongoing debate on the future of EU policy-making
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