1,720,986 research outputs found
Caratterizzazione di ceppi di Listeria monocytogenes isolati da alimenti di origine animale
No full textE' stata ricercata la presenza di L.monocytogenes in differenti alimenti di origine animale, per studiare la diffusione di questo patogen
A comparative study of a surgical method and scaling and root planing using the Odontoson(R)
No full textThis investigation compared a traditional periodontal surgical method with a non-surgical treatment of scaling and root planing by an ultrasonic device (Odontoson M(R)) using irrigation with an iodised solution. 8 adult patients with periodontal disease were each treated at 2 randomly chosen quadrants by a Widman flap type surgical technique, and the remaining non-surgically. The patients then attended bi-monthly oral hygiene sessions over a period of 1 year. At that stage, clinical evaluation revealed that the Odontoson M(R) plus an ionized irrigant solution achieved a statistically comparable outcome to that of surgical treatment, even in the pockets initially up to 7 mm in depth
RHODOTORULA-GLUTINIS KERATITIS
No full textThe authors report a case of deep keratomycosis, revealed by penetrating keratoplasty to be due to Rhodotorula glutinis
Naphthofuranone derivatives as specific inhibitors of thymidylate synthases
No full textSynthetic compounds of 1, 2 -naphthalein molecules (I) having specific inhibitory properties of the enzymatic activity of thymidylate synthases of bacterial species, their preparation, their pharmaceutical composition and use in the treatment and prophylaxis of infectious pathologies are disclosed
FLAVONOIDS AND ANTIMYCOTICS: A POSSIBILE SYNERGISTIC COMBINATION FOR THE TREATMENT OF CANDIDIASIS AND CRYPTOCOCCOSIS.
No full textThe treatment of candidiasis and cryptococcosis is based on the use of antimycotic drugs such as amphotericin B, 5-fluorocytosine, miconazole and fluconazole. Isoliquiritigenin is a member of the flavonoids and data in scientific literature assert that these compounds can modulate the biosynthesis of endogenous sterols, which are known to be very important for the survival of mycete. In this study we investigated the antifungal effect of isoliquiritigenin on strains of Candidae spp and C.neoformans cultured on Sabouraud medium. Amphotericin B, 5-fluorocytosine, miconazole and fluconazole were chosen as reference drugs. Sensitivity tests were performed in according with the NCCLS method for agar dilution and MIC values were calculated for all the substances. No antifungal activity was evident in cultures treated with isoliquiritigenin (MIC values >100mg/L) while, very interesting results came from the combination: isoliquiritigenin/ antifungal drugs used at inhibitory and sub-inhibitory concentrations on yeast cultures (isoliquiritigenin 50-10mg/L, amphotericin B 10-0.1mg/L, 5-fluorocytosine 2.5-0.5mg/L, miconazole 0.25-0.05, fluconazole10-0.1mg/L). The FIC index used to estimate the interactions outcomes was also calculated. The association of isoliquiritigenin with the antimycotic often resulted in a synergic effect with addition (0.55<FIC index<1). In few cases we observed indifference (1<FIC index<2). Antagonism never appeared. Finally, we performed the MTT test on Vero cells to evaluate the toxic effect of the dosages used in the combinations. The results from the MTT test performed on Vero coltures added with the drugs used alone or in association showed the low toxicity of the combinations
Epidemiological investigation on a suggestive case of Legionella pneumonia and public health implications
No full textWe report a case of Legionella pneumonia in a patient with psoriasis. The clinical strain had an identical PFGE pattern of 1 subtype of L. pneumophila serogroup 1 isolated at low concentration in a sporting club bath. Diagnostic, clinical and epidemiological aspects are discussed for their relevant public health implications
Search for viruses in the CSF of patients with acute neurological disorders: possible involvement of beta-and gamma-herpesviruses
No full textIn the years 1999-2001, 868 samples of cerebrospinal fluid (CSF) from as many patients with acute neurological manifestations of suspected viral origin were analysed for the presence of viruses at the Centre for the Diagnosis of Viral Diseases of the University of Modena and Reggio Emilia. Neurological patients included 788 immunocompetent subjects and 80 patients with impaired immunity due to human immunodeficiency virus (HIV) seropositivity. Of the CSF samples, 125 (15.8%) were positive for one or more viruses among the immunocompetent patients, whereas 33 (41.1%) were positive among the HIV cohort. DNA and RNA viruses were detected in the first group of CSF samples whereas only DNA viruses were found in the second group. In immunocompetent patients the frequency of enteroviruses prevailed over that of other RNA virus families (p = 0.001) and that of herpesviruses over the frequency of other DNA virus families (p = 0.001). Among herpesvirus members, the Epstein-Barr gamma-herpesvirus prevailed on alpha-herpesviruses in each of the two groups of patients (p = 0.05 in the immunocompetent group and p = 0.006 in HIV-positive patients). The clinical relevance both of this virus and of beta-herpesviruses as a cause of neurological disorders is discussed
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