2,650 research outputs found
CIND and MCI in the Italian elderly: frequency, vascular risk factors, progression to dementia
No full textParkinsonitis (Presentation Video)
No full textSubacute change in mental status; Akinetic-rigid parkinsonian featuresAn 83-year old male with a 2-year history of motor, left gaze palsy and cognitive slowing. Previous history significant for hypertension, hypercholesterolemia, Gilbert syndrome, and atrial fibrillation.VA: 20/50 OD, 20/60 OS; Color plates: 9/15 OUCT; MRIElevated ESR; Parkinsonian syndromeIV anti-inflammatory agents; Corticosteroids1. Caselli RJ. Giant cell (temporal) arteritis: A treatable cause of multi-infarct dementia. Neurology 1990; 40: 753. 2. Caselli RJ. Hunder GG. Neurologic complications of giant cell (temporal) arteritis. Semin Neurol 1994;14(4): 349-53. 3. Caselli RJ. Hunder GG. Whisnant JP. Neurologic disease in biopsy-proven giant cell (temporal) arteritis. Neurology 1988; 38(3): 352-9. 4. Fietta P, Manganelli P. Steroid-reversible parkinsonism as presentation of polymyalgia rheumatica. Clin Rheumatol 2006; 25: 564-565. 5. Monteiro MLR, Coppeto JR, Greco P. Giant cell arteritis of the posterior cerebral circulation presenting with ataxia and ophthalmoplegia. Arch Ophthalmol 1984; 102: 407
Parkinsonitis
No full textSubacute change in mental status; Akinetic-rigid parkinsonian featuresAn 83-year old male with a 2-year history of motor, left gaze palsy and cognitive slowing. Previous history significant for hypertension, hypercholesterolemia, Gilbert syndrome, and atrial fibrillation.VA: 20/50 OD, 20/60 OS; Color plates: 9/15 OUCT; MRIElevated ESR; Parkinsonian syndromeIV anti-inflammatory agents; Corticosteroids1. Caselli RJ. Giant cell (temporal) arteritis: A treatable cause of multi-infarct dementia. Neurology 1990; 40: 753. 2. Caselli RJ. Hunder GG. Neurologic complications of giant cell (temporal) arteritis. Semin Neurol 1994;14(4): 349-53. 3. Caselli RJ. Hunder GG. Whisnant JP. Neurologic disease in biopsy-proven giant cell (temporal) arteritis. Neurology 1988; 38(3): 352-9. 4. Fietta P, Manganelli P. Steroid-reversible parkinsonism as presentation of polymyalgia rheumatica. Clin Rheumatol 2006; 25: 564-565. 5. Monteiro MLR, Coppeto JR, Greco P. Giant cell arteritis of the posterior cerebral circulation presenting with ataxia and ophthalmoplegia. Arch Ophthalmol 1984; 102: 407
Parkinsonitis (PowerPoint)
No full textSubacute change in mental status; Akinetic -rigid parkinsonian featuresAn 83-year old male with a 2-year history of motor, left gaze palsy and cognitive slowing. Previous history significant for hypertension, hypercholesterolemia, Gilbert syndrome, and atrial fibrillation.VA: 20/50 OD, 20/60 OS; Color plates: 9/15 OUCT; MRIElevated ESR; Parkinsonian syndromeIV anti-inflammatory agents; Corticosteroids1. Caselli RJ. Giant cell (temporal) arteritis: A treatable cause of multi-infarct dementia. Neurology 1990; 40: 753. 2. Caselli RJ. Hunder GG. Neurologic complications of giant cell (temporal) arteritis. Semin Neurol 1994;14(4): 349-53. 3. Caselli RJ. Hunder GG. Whisnant JP. Neurologic disease in biopsy-proven giant cell (temporal) arteritis. Neurology 1988; 38(3): 352-9. 4. Fietta P, Manganelli P. Steroid-reversible parkinsonism as presentation of polymyalgia rheumatica. Clin Rheumatol 2006; 25: 564-565. 5. Monteiro MLR, Coppeto JR, Greco P. Giant cell arteritis of the posterior cerebral circulation presenting with ataxia and ophthalmoplegia. Arch Ophthalmol 1984; 102: 407
Reformulating the rj-McMC Algorithm for 3D Inversion of Passive Seismic Data for Near-Surface Characterization
No full textGeophysical subsurface characterization techniques could, due to their non-invasive nature, play a crucial role in the design and subsequent construction of infrastructure in urban & industrial environ- ments. Geo-data specialist company Fugro sees potential in upgrading their current ambient-seismic- noise-tomography workflow, to make use of state-of-the-art inversion schemes with the main goal of increasing the quality and accuracy of the initial-site characterization delivered to clients. In this thesis I explore the feasibility of utilizing the reverse-jump Markov chain Monte Carlo (rj-McMC) algorithm for the inversion of ambient seismic noise for characterization in urban & industrial environments. Specif- ically, testing the potential of scaling down this inversion algorithm to fit in a small scale, near-surface framework. To achieve this, I first carried out analyses to evaluate the appropriate Rayleigh wave frequency range, after which realistic noise hyperparameters, suited for this reduced scale problem, were obtained. Because of the potential exploitation of in-situ borehole measurements, I reformulated the Bayesian prior within the rj-McMC algorithm to implement these constraining shear wave velocity values appropriately. I conducted extensive synthetic experiments to gain insight into the behavior of this adapted algorithm, from which it was concluded that the inherent dynamic discretization partially prevents these constraints from being implemented to their full extent. Nevertheless, promising results lead me to conclude that the use of the rj-McMC algorithm for application in near-surface urban & industrial environments is feasible.Applied Geophysics | IDEA Leagu
Clowns, Fools, and Killers: An Exploration of Horror, Comedy, and Madness Through the Roles of Murderer 2 and Sir Richard Ratcliffe in William Shakespeare\u27s Richard III
Get PDFThis document is a thesis submitted in partial fulfillment of the Master of Fine Arts degree in Theatre Arts with a Concentration in Musical Theatre. It is a detailed account of author RJ Magee’s artistic and scholarly process in creating the roles of Murderer 2 and Sir Richard Ratcliffe in William Shakespeare’s Richard III. The production was performed as part of Minnesota State University, Mankato’s mainstage season in October of 2022. In five chapters, this thesis chronicles the actor’s process: a preproduction analysis, a historical and critical perspective, a rehearsal and performance journal, a post-production analysis, and a process development analysis. Appendices and works cited are included
Regional network of magnetic resonance imaging gray matter volume in healthy aging
No full textHealthy aging has been associated with brain volume reductions preferentially affecting the frontal cortex, but also involving other regions. We used a network model of regional covariance, the Scaled Subprofile Model, with magnetic resonance imaging voxel-based morphometry to identify the regional distribution of gray matter associated with aging in 26 healthy adults, 22-77 years old. Scaled Subprofile Model analysis identified a pattern that was highly correlated with age (R2=0.66,
Cognitive frailty: Predementia syndrome and vascular risk factors
No full textWith increasing emphasis on early diagnosis of Alzheimer disease (AD), clinical research has focused on the identification of risk factors
that may be modified at a preclinical and early clinical stage of dementing disorders. Prevalence and incidence of different predementia
syndromes vary as a result of different diagnostic criteria, as well as different sampling and assessment procedures. Particular interest in mild
cognitive impairment (MCI) arises from the fact that MCI is thought to be a prodromal phase and therefore highly predictive of subsequent
AD. Furthermore, many of the risk factors for cerebrovascular disease (CVD) and vascular dementia (VaD), including serum total cholesterol,
hypertension, atherosclerosis, and apolipoprotein E (APOE) genotype have also been shown to increase the risk of AD. Both vascular factors
and APOE 4 allele have been associated with higher risk of AD. Some recent studies suggested further that CVD or vascular factors
increased the risk of conversion of MCI to dementia. This review will focus on the possible role of vascular risk factors in modulating the risk
of age-related cognitive decline, and the progression of predementia syndrome such as MCI to dementia
Current epidemiology of mild cognitive impairment and predementia syndromes.
No full textvariety of clinically-defined predementia syndromes, with differing diagnostic criteria and nomenclature, have been proposed to describe nondisabling symptomatic cognitive deficits arising in elderly persons. Incidence and prevalence of different predementia syndromes vary as a result of different diagnostic criteria, sampling, and assessment procedures. The incidence rates of all predementia syndromes increase with age and are higher in subjects with less education; but age, educational background, and gender are not consistently related to prevalence rates. There is particular interest in “Mild Cognitive Impairment (MCI)” because this predementia syndrome is thought to be a prodromal phase of Alzheimer disease (AD). Several studies have
suggested that most patients who meet MCI criteria will progress to AD, but rates of conversion to AD and dementia vary widely among studies. Furthermore, MCI definition is less consistent in population-based studies than clinical studies, in which progression to AD is also more consistent. To clarify the sources of discrepant findings in the literature, this review summarizes existing epidemiological studies of the defined clinical predementia syndromes and their progression to dementia
Italian Longitudinal Study on Aging Working Group. Incident occurrence of depressive symptoms among patients with mild cognitive impairment - the Italian longitudinal study on aging
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