100,909 research outputs found
Tradition and innovation in zero energy balance and zero CO2 emission housing development
No full textThe paper presents a research study and a final design proposal for new social housing in the peri-urban context of Tricase, a town located in Puglia in the south of Italy.
The context reading and design procedure aim at investigating the energy and environmental potential of both outdoor spaces and new housing design as an integrated system within the urban rehabilitation procedure of a fringe peri-urban and degraded area: “sustainable” paths linking the open spaces within the area -and the same area to the remaining part of the city- have been regarded as key elements to improve local urban conditions.
The building design combines passive tools (high thermal inertia brick wall structures -as an evolution of the traditional stone construction of the region-, high albedo materials, solar shading devices, ventilation strategies, etc.) with solar and wind energy micro-generation, resulting in a comprehensive plan for “Zero local CO2 emission and Zero Energy balance” housing development. Further investigations were conducted to accurately assess the study of the thermal performance of the buildings, using different software tools and a CFD simulation with Ansys CFX for natural ventilation strategies. Results show that integration of active and passive techniques in urban and building types can lead to feasible, energy-efficient and low-cost solutions where the respect of tradition may translate into high quality performing buildings within recognizable urban environments. In the search for a reasonable co-habitation between innovation and tradition, it is therefore evident that technological innovation –if specifically integrated within built landscapes and new building types- can even be enhanced by the critical reading of context and the awareness of existing environmental resources
Letter, [Author unclear] to Paulina T. Merritt
No full textHandwritten letter to Paulina Merritt from an unknown author, October 1, 1876.
Penile Metastases from Renal Cell Carcinoma: Pre and Postcontrast Sonographic Findings
No full textThe prostate and bladder are the most common primary cancer sites for penile metastases. Here, we describe an unusual case of metastases from renal cell carcinoma to the penis discovered 1 month after nephrectomy in a 60-year-old man. The diagnosis was achieved using B-mode and contrast-enhanced ultrasound
Transarterial (chemo)embolization and radiofrequency ablation for patients with hepatic metastases (mts) of head and neck carcinoma (HNC) resistant to systemic treatment
No full textToward Chemically Resolved Computer Simulations of Dynamics and Remodeling of Biological Membranes
No full textCellular membranes are fundamental constituents of living organisms. Apart from defining the boundaries of the cells, they are involved in a wide range of biological functions, associated with both their structural and the dynamical properties. Biomembranes can undergo large-scale transformations when subject to specific environmental changes, including gel-liquid phase transitions, change of aggregation structure, formation of microtubules, or rupture into vesicles. All of these processes are dependent on a delicate interplay between intermolecular forces, molecular crowding, and entropy, and their understanding requires approaches that are able to capture and rationalize the details of all of the involved interactions. Molecular dynamics-based computational models at atom-level resolution are, in principle, the best way to perform such investigations. Unfortunately, the relevant spatial and time dimensionalities involved in membrane remodeling phenomena would require computational costs that are today unaffordable on a routinely basis. Such hurdles can be removed by coarse-graining the representations of the individual molecular components of the systems. This procedure anyway reduces the possibility of describing the chemical variations in the lipid mixtures composing biological membranes. New hybrid particle field multiscale approaches offer today a promising alternative to the more traditional particle-based simulations methods. By combining chemically distinguishable molecular representations with mesoscale-based computationally affordable potentials, they appear as one of the most promising ways to keep an accurate description of the chemical complexity of biological membranes and, at the same time, cover the required scales to describe remodeling events
Is the ovulation induction still a therapeutic problem in patients with polycystic ovary syndrome?
No full textIs ovulation induction still a therapeutic problem in patients with polycystic ovary syndrome?
No full textPolycystic ovary syndrome (PCOS) is one of the most common endocrine diseases affecting women of fertile age, and is characterized by hyperandrogenism, chronic anovulatory cycles and oligomenorrhea or amenorrhea. Given the repercussions of chronic anovulation on sterility, PCOS is a heavy social burden. Here we describe the procedures used to induce ovulation in PCOS patients, the surgical approach and medical treatments that are still being experimented. (C) 2004, Editrice Kurtis
Unlocking Pandora’s Box: Unravelling nested futures directions of the AI in tourism and hospitality through an umbrella review
No full textThis study provides a comprehensive meta-review of extant literature and meta-analyses focusing on the application of Artificial Intelligence (AI) in the Tourism and Hospitality (T&H) sector. More in depth, the research aims to map the trajectory of AI research within T&H, identifying prevailing themes, tools and approaches and critically examining the impact of AI integration. A systematic literature review is conducted using Scopus and Web of Science databases, targeting articles that explicitly discuss AI in T&H sector. The analysis includes a co-word network analysis to create a semantic map and employs community detection algorithms to identify clusters of thematically related keywords. The findings reveal a significant increase in AI-related publications, highlighting global interest in AI applications across diverse contexts, especially in T&H sector. Key results indicate that AI enhances operational efficiencies and customer service, with tools such as chatbots and predictive analytics demonstrating notable success in improving guest experience. The implications of the findings underscore the need for stakeholders, entrepreneurs, policymakers and researchers to understand and leverage AI's potential to define and implement innovative strategies in T&H. This review contributes original insights into the current state of AI research within the sector, identifies gaps for future investigation and serves as a foundational reference for those navigating the integration of AI technologies in T&H practices
Handwritten biographical information on Paulina T. McClung Merritt
No full textA handwritten biography of Paulina T. McClung Merritt by an unknown author, 1892.
Heterogeneous and tissue-specific regulation of effector T cell responses by IFN-gamma during Plasmodium berghei ANKA infection.
No full textIFN-γ and T cells are both required for the development of experimental cerebral malaria during Plasmodium berghei ANKA infection. Surprisingly, however, the role of IFN-γ in shaping the effector CD4(+) and CD8(+) T cell response during this infection has not been examined in detail. To address this, we have compared the effector T cell responses in wild-type and IFN-γ(-/-) mice during P. berghei ANKA infection. The expansion of splenic CD4(+) and CD8(+) T cells during P. berghei ANKA infection was unaffected by the absence of IFN-γ, but the contraction phase of the T cell response was significantly attenuated. Splenic T cell activation and effector function were essentially normal in IFN-γ(-/-) mice; however, the migration to, and accumulation of, effector CD4(+) and CD8(+) T cells in the lung, liver, and brain was altered in IFN-γ(-/-) mice. Interestingly, activation and accumulation of T cells in various nonlymphoid organs was differently affected by lack of IFN-γ, suggesting that IFN-γ influences T cell effector function to varying levels in different anatomical locations. Importantly, control of splenic T cell numbers during P. berghei ANKA infection depended on active IFN-γ-dependent environmental signals--leading to T cell apoptosis--rather than upon intrinsic alterations in T cell programming. To our knowledge, this is the first study to fully investigate the role of IFN-γ in modulating T cell function during P. berghei ANKA infection and reveals that IFN-γ is required for efficient contraction of the pool of activated T cells
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