196,046 research outputs found

    Lo studio FAST: FAringotonsillite STreptococcica in età pediatrica. Impatto farmacoeconomico delle Linee Guida dell'American Academy of Pediatrics sulla pratica clinica di 600 pediatri italiani

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    The American Academy of Pediatrics (AAP) has recently published its new guidelines for the treatment of pediatric tonsillopharyngitis; a diagnostic test for the detection of streptococci is recommended, followed by a treatment with penicillins (10 days) or cephalosporins (5 days) in case of positivity, and by no treatment otherwise. The success of a guideline, in general, depends on its diffusion in practice and on its adaptability to different local settings. The aim of the present study (FAST) was the evaluation of the clinical and economical impact of the application of the AAP guidelines in the Italian reality. The study was conducted with the cooperation of 600 pediatricians, uniformly distributed on the Italian territory, and involved 3072 patients. The pediatricians were left free to decide whether to follow the guidelines or not. The results of the analysis indicate that only some 20% of the pediatricians adhered to the suggested protocol; the total cost (calculated in the perspective of the National Health System, with a time horizon of about 3 months) per patient, nonetheless, resulted inferior in the group treated according to the proposed protocol (50,45 • vs. 53,30 •). Furthermore, a lower incidence of complications occurred in these patients. Among the “off-protocol” behaviors, two showed particularly evident misuse of health resources: inappropriate treatment after test positivity (59,15 •/patient), and treatment after test negativity (14% of the total population). Another interesting, although not surprising, result of this study was the evidence that penicillins are as effective as cephalosporins in the short-term, but significantly inferior in terms of complications, positivity for streptococci at the control test, and complications detected at follow-up

    Ideazione di un casco ventilato di saldatura con caratteristiche funzionali migliorate

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    Sviluppo di un nuovo casco ventilato da saldatura ottenuta facendo ricorso a strumenti di Computational FLuid Dynamics (CFD) con caratteristiche migliorate rispetto a quanto reperibile sul mercato allo stato dell'arte

    Erratum: An economic evaluation of aripiprazole vs olanzapine adapted to the Italian setting using outcomes of metabolic syndrome and risk for diabetes in patients with schizophrenia. Neuropsychiatr Dis Treat, 4: 967–976

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    ErratumColombo GL, Caruggi M, Di Matteo, et al. 2008. An economic evaluation of aripiprazole vs olanzapine adapted to the Italian setting using outcomes of metabolic syndrome and risk for diabetes in patients with schizophrenia. Neuropsychiatr Dis Treat, 4: 967–976.Page 972, Results, right column, last paragraph. The second sentence should read:In the simulated cohort of 1000 patients, the values with aripiprazole for 26 weeks showed the avoidance of 34 events of diabetes over 5 years (28 in discounted scenario), resulting in total cost savings of €1,933.24 (€1,472.52 in discounted scenario).Page 973, Table 5:Under Events avoided/1000 schizophrenia patients (5 years): 18 should read 28.Under Cost/metabolic syndrome avoided (5 years): −€2,860.52 should read −€1,852.73

    Effect of Ohmic Heating on the Formation and Texture of Acid Milk Gels

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    This study aimed to describe the effects of ohmic heat treatment (OHT) of milk on the formation and properties of acid milk gels. The influence of voltage gradient (25, 40, 55 V/cm), holding time (2, 16, 30 min), and final temperature (45, 65, 75, 85 °C) on rheological properties and particle size distribution was measured during the gelation process. Texture properties and syneresis of the samples were evaluated at the end of the gelation process. Scanning electron microscopy (SEM) micrographs of the acid milk gels were also taken at pH 4.6(i.e., pI or Isoelectric point of casein). Results indicated that oscillatory time sweep tests were more accurate than particle size measurements in detecting gelation onset. Complex modulus values of the final gel showed that OHT of the milk at 25 V/cm and holding at 85 °C for 16 min gave rise to a 21% higher structural strength compared to when using the conventional heat treatment (CHT) where temperature was 85 °C and holding time and come up time were 30 and 20 min respectively. In other words, by using the OHT milk, the same gel strength as that of CHT 85 °C sample was obtained by spending 185 min instead of 328 min incubation time (i.e., 40% less time). Higher voltage gradient lowered the final gel strength when temperature and holding time kept constant at 85 °C and 16 min respectively. Results indicated that the gel firmness enhanced and the amount of syneresis decreased when CHT was replaced by OHT in the manufacturing process. SEM revealed that the protein matrices of ohmic heating samples appeared to be more compact and denser with smaller pore size than observed in the conventional gel. Results indicated that OHT of milk successfully improves the quality of acid milk gels and obviate the need for increasing dry matter concentration or using additives
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