88,463 research outputs found
An experience with paediatric burn wounds treated with a plantderived wound therapeutic
No full textl O bjective: To observe the efficacy of a plant-derived wound dressing (1 Primary Wound Dressing®), a mixture of hypericum and neem oil, in different types of paediatric burns. l Method: A retrospective review was conducted over the complete healing course of 9 paediatric patients with a mean age of 8.17±3.35 (1-11 years), presenting mixed, partial or full-thickness burns. The treatment applied by the wound care specialist consisted of daily cleansing of the wound with a saline solution and application of 1 Primary Wound Dressing on the whole wound surface. There was no application of a secondary dressing. The time to heal, wound size, ease of handling, pain and complications were recorded. Procedural and background pain were observed in six of the patients older than 5 years (mean age 9.6±2.39, range 8-11 years). Due to the small number of patients examined during the period studied, it was not possible to perform statistical analyses. l Results: The mean wound size was 50.76±48.32cm2 (4.63-132.0cm2). A rapid induction of granulation tissue and re-epithelialisation was observed. Time to complete healing was 16.6±4.69 days (10-22 days). No complications related to wound infection was observed. The 6 patients older than five years reported a strong relief of pain, from an initial value of 7-8 out of 10 to 0 out of 10 within the first week of treatment. This remained at the 0 out of 10 level during the second and third weeks of treatment. l Conclusion: This retrospective, non-controlled examination suggests that 1 Primary Wound Dressing could be an effective therapy for the treatment of burn wounds, with benefits including pain reduction and simplicity of use. Further evaluations with a larger population are required to document the effectiveness of this plant-derived wound dressing in a controlled fashion. l Declaration of interest: There were no external sources of funding for this study. F. Carnevali is a researcher and co-inventor of 1 Primary Wound Dressing®
Evidence for the 'cellular calcium regulation hypothesis' from 'simple' mutable collagenous structure: the brachial and cirral syzygial ligaments of Antedon mediterranea (Lam.)
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5th International Workshop on the Biology of Fish Gametes Evidences of a series growing in numbers and quality
No full textAsturiano Nemesio, JF.; Horváth, Á.; Carnevali, O. (2017). 5th International Workshop on the Biology of Fish Gametes Evidences of a series growing in numbers and quality. General and Comparative Endocrinology. 245:1-4. doi:10.1016/j.ygcen.2017.03.004S1424
On Bookchin's Hidden Spinozism
No full textThis paper argues that Murray Bookchin’s conception of matter and thought aligns with Spinoza’s views, particularly as outlined in Spinoza’s treatment of bodies in the second part of the Ethics. I argue that Bookchin’s redefinition of matter in terms of a dynamic interaction of self-organized organisms echoes Spinoza’s conception of bodies. Both thinkers reject a fundamental separation between humans and nature, recognizing human complexity as a natural outgrowth of nonhuman organization. Furthermore, I read Bookchin’s ideas on natural mind alongside Hasana Sharp’s renaturalization of ideology, which emphasizes Spinoza’s notion of a transindividual power of thinking involving both human and nonhuman beings. I maintain that this conception of thought challenges modern science’s view of nature as an object of thought but not a thinking entity, thus theorizing a power of thinking inherent to nature. By reconceptualizing matter, rationality, and science, this approach forms the basis of an ecological ethics that recognizes alterity as an active element in natural and social history, grounding Bookchin’s theory of ecological ethics in Spinoza’s philosophy
Stress and regeneration in crinoids and asteroids
No full textComplete and functional regrowth of arms in echinoderms depends on several factors. Probably the most crucial are the site of amputation along the proximal-distal axis of the arm, particularly important in crinoids (Candia Carnevali et al 1995), and the ambient temperature, as seen in the ophiuroid A. filiformis (Mallefet et al 2000). Indeed, a traumatic amputation that does not follow the natural autotomy plane may involve more complex reparative/regenerative mechanisms and therefore may be slower compared to the non traumatic (Candia Carnevali et al 1995). Whatever the selected regenerative ‘pathway’, massive tissue rearrangement and strong up-regulation of cell proliferation/differentiation was detected in all the species investigated in this thesis. However, the time course of these events does vary dependent upon the regenerative ‘pathways’.
During the arm regeneration process, these animals might experience stress which may be accompanied by a large turnover of protein. Generally, when an organism is subject to metabolic and environmental stressors, a common protective mechanism, known as the stress response, is activated (Srinivas and Swamynathan 1996; Morimoto 1998). This results in the expression of heat-shock proteins (Hsps). It is known that Hsps, which are encoded by highly conserved families of genes, play key roles not only in the correct folding of proteins (and hence repair processes following damage) but also during normal development (Becker and Craig 1994). One specific example occurs in Drosophila where small increases in Hsp70 expression during development enhances thermotolerance (Feder 1999) but if overexpression of the Hsp70 gene is induced, larval mortality increases and development slows down (Krebs and Feder 1997).
Amongst invertebrates, echinoderms are well known for their extensive capacity for regeneration following natural predation-induced trauma or as a part of reproductive strategy (Candia Carnevali et al 1998). Echinoderm classes with arms are often subject to frequent arm loss. Clearly such autotomy followed by subsequent repair and regeneration is likely to represent a stressful event.
Ubiquitin is a small, (76 amino acids) highly conserved phylogenetically, protein and is present in all eukaryotes (Finley and Chau, 1991; Hochstrasser, 1996). Although ubiquitin occurs free in the cell, it is most commonly found covalently conjugated to a wide range of target proteins. This conjugation is a reversible post-translational modification, which has been implicated, in numerous biological processes. Ubiquitin plays important roles in a range of cellular functions including the cell cycle, DNA replication, DNA repair and signal transduction (Deshaise 1995; Muller and Schwartz 1995; King et al 1996). One important and well-known function of ubiquitination is to target proteins for rapid degradation by the 26S proteasome, a protease complex present in both the cytoplasm and the nucleus (Arrigo et al 1988). In this ATP-dependent pathway, a protein is tagged with poly-ubiquitin chains via isopeptide bonds, which are formed between the carboxyl terminal glycine of ubiquitin molecules and the ε-amino groups of lysine residues in other ubiquitin molecules. This ubiquitinating reaction (Fig. 1) is catalysed by sequential actions of E1 (ubiquitin-activating enzyme), E2 (ubiquitin-conjugating enzyme), and often E3 (ubiquitin-ligase). When cells are exposed to heat shock, many aberrant proteins are produced and the ubiquitin-dependent proteolytic pathway (the ubiquitin-proteasome system) is believed to play a key role in rapid degradation of these abnormal proteins (Schwartz and Ciechanover 1999).
In contrast, some proteins, such as the histones H2A and H2B, are ubiquitinated but not subsequently degraded. It is still unclear whether these ubiquitin molecules are attached to histones via the poly-ubiquitin chain or not. Thus, it is still uncertain why and how ubiquitinated histones are deubiquitinated in response to heat-shock, during chromosome condensation in the mitotic cell cycle, in apoptosis and during neuronal differentiation in PC12h cells (Bond et al 1988; Takada et al 1994; Marushige and Marushige 1995)
Nitidobulbon nasutum Ojeda & Carnevali, Novon
No full textNitidobulbon nasutum (Rchb.f.) Ojeda & Carnevali, Novon 19: 99. 2009. Voucher: F. Matthews s.n. (SEL)Published as part of Vega, Hermes, Cetzal-Ix, William, Mó, Edgar, Romero-Soler, Katya J. & Basu, Saikat K., 2022, An Updated Checklist of the Orchidaceae of Honduras, pp. 1-80 in Phytotaxa 562 (1) on page 63, DOI: 10.11646/phytotaxa.562.1.1, http://zenodo.org/record/707369
Prosthechea crassilabia (Poepp. y Endl.) Carnevali y I. Ramírez
No full textUPTC_20522FloraSantanderCañaveralCañaveralVirolínProsthechea crassilabia (Poepp. y Endl.) Carnevali y I. RamírezPlantaeLiliopsidaLilialesOrchidaceaeProsthecheacrassilabiaCharal
I Carnevali contemporanei e il rapporto con la tradizione
No full textI Carnevali contemporanei che si richiamano a una pretesa tradizione locale, più o meno lunga nel tempo e più o meno fondata storicamente, si presentano come esito di un processo di “ritradizionalizzazione”, che è fondato su forme di riapprendimento delle tradizioni locali come necessario pressupposto perché esse, un tempo pratiche sociali, riemergano nel presente come patrimoni culturali. L’esito di tale processo, che poggia in parte sulla convinzione della continuità di atti e comportamenti, in parte, se non soprattutto, sul potere autorevole e fondativo della scrittura, è l’assunzione di consapevolezza del loro essere nella contemporaneità segni di uno stile tradizionale che diventa marcatore di distinzione e di differenza. Conseguentemente anche le maschere, all’interno del prevalente carattere scenico, teatrale e ludico dei Carnevali attuali, assumono il significato e il valore di simboli culturali, utili alla ridefinizione delle identità locali e territoriali.
In tale prospettiva, quel che colpisce in diversi Carnevali contemporanei è la tendenza a stare nell’attualità ricorrendo all’inattuale, attingendo cioè all’arcaico e rivitalizzandolo sul piano della comunicazione, e a farne oggetto di un discorso della e sulla contemporaneità. Essi hanno così, in molti casi, contribuito, grazie anche al ricorso a forme di creatività culturale come capacità di innovare modelli preesistenti e divenuti oggetto di patrimonializzazione, alla costruzione delle identità locali e alla loro esibizione all’interno di politiche centrate su progetti di turismo alternativo e culturale.Contemporary Carnivals that are claimed to make reference to a specific, more or less longstanding or historically verified, local tradition appear to be the outcome of a process of “retraditionalization” based on means of relearning local traditions: a necessary prerequisite for them, which used to be social practices, to resurface today as cultural heritage. Such process is partly based on the assumption that actions and behaviors are persistent and partly – if not especially – on the authority and foundational power of writing, and its outcome is the acquisition of awareness of their being the signs of a traditional style that marks a distinction. Thus, within the scope of todays’ prevailing picturesque, theatrical, and playful character of Carnivals, they acquire the meaning and value of cultural symbols that assist the redefinition of local identities.
From this perspective, contemporary Carnivals have the striking tendency to be timely by referring to the untimely, namely by drawing on the archaic and revitalizing it through communication, picking it as the topic of a discourse of and about the contemporary. This way, they have in many cases contributed, also thanks to forms of cultural creativity seen as the ability to innovate pre-existing models that have become objects of heritagization, to the construction of local identities and their exhibition within the scope of politics that focus on alternative and cultural tourism
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