1,721,170 research outputs found
Ricerche per Lidia: il femminismo nelle arti visive, nel corpo, nelle migrazioni, nella fantascienza, nel presente e futuro interspecie - volume 2
No full textWeaving a pas de deux: Cultural Studies and the History of Ideas
No full textThis contribution intends to weave a dialogue - a pas de deux of sorts - between the history of ideas and cultural studies. On the one hand, it is inevitable to register the historical, disciplinary, even ideological distances between these two critical bodies, especially in the way they deal with cultural history. However, it is also possible to explore a common ground, for example in the analysis of the semantic component of the history of thought that emerges from two concurrent works such as Philip P. Wiener's Dictionary of the History of Ideas (1973-74) and Raymond Williams' Keywords (1976). These and other seminal texts in the two fields elaborate an explicitly interdisciplinary methodology, from which to explore further contiguities that emerge palpably, though not often explicitly, when the history of ideas is confronted with cultural practices. In particular, it is in the approach to the literary text and, more broadly, to the question of aesthetics, that we will try to interweave these critical movements, appreciating the new configurations, new choreographies of thought, that emerge from their encounter
Correlation between serum tryptase, mast cells positive to tryptase and microvascular density in colo-rectal cancer patients. Possible biological-clinical significance.
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(de)gendering the postcolonial Postcoloniali e generi – postcoloniali degeneri
No full textIl primo numero di de genere intende aprire la discussione su una vasta piattaforma di temi e attivare una rete di interventi critici. I contributi inclusi qui esplorano la triangolazione tra gli studi letterari, postcoloniali e di genere, e testimoniano la fertilità e la varietà di ricerche perseguite da studiose e studiosi che fanno riferimento ad approcci diversi, che vanno dalle scienze sociali agli studi di area, dalle letterature comparate alla teoria critica e all'attivismo. Il nostro obiettivo è di dare inizio ad un dialogo attraverso le strutture e i confini disciplinari, dialogo che speriamo prosegua nei numeri a venire.The first issue of de genere intends to open the discussion on a broad range of topics and activate a critical network of interventions. The contributions included here explore the triangulation among literary, gender and postcolonial studies, and bear witness to the fertility and diversity of research by scholars encompassing different approaches, from social studies through area studies and comparative literature up to critical theory and activism. Its and our aim is to set the pace for a dialogue through disciplinary boundaries and frameworks – which will hopefully continue in the following issues
Lipid metabolism in colon cancer: Role of Liver X Receptor (LXR) and Stearoyl-CoA Desaturase 1 (SCD1)
No full textColorectal cancer (CRC) is one of the most commonly occurring cancers worldwide. Although several genetic alterations have been associated with CRC onset and progression, nowadays the reprogramming of cellular metabolism has been recognized as a fundamental step of the carcinogenic process. Intestinal tumor cells frequently display an aberrant activation of lipid metabolism. Indeed, to satisfy the growing needs of a continuous proliferation, cancer cells can either increase the uptake of exogenous lipids or upregulate the endogenous lipogenesis and cholesterol synthesis. Therefore, strategies aimed at limiting lipid accumulation are now under development in order to counteract malignancies. Two major players of lipids metabolism have been so far identified for their contribution to CRC development: the nuclear receptor Liver X Receptor (LXRs) and the enzyme Stearoyl-CoA Desaturase 1 (SCD1). Whereas LXR is mainly recognized for its role as a cholesterol sensor, finally promoting the loss of cellular cholesterol and whole-body homeostasis, SCD1 acts as the major regulator of new fatty acids, finely tuning the monounsaturated fatty acids (MUFA) to saturated fatty acids (SFA) ratio. Intriguingly, SCD1 is directly regulated by LXRs. Despite LXRs agonists have elicited great interest as a promising therapeutic target for cancer, LXR's ability to induce SCD1 and new fatty acids synthesis represent a major obstacle in the development of new effective treatments. Thus, further investigations are required to fully dissect the concomitant modulation of both players, to develop specific therapies aimed at blocking intestinal cancer cells proliferation, eventually counteracting CRC progression
The gut-liver axis in cholangiopathies: Focus on bile acid based pharmacological treatment
Full text linkPurpose of reviewThis review analyses the main features of primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) and provides an overview of the currently available (bile acid) bile acid related treatments.Recent findingsIn PBC, biliary injury is the consequence of a dysregulated intrahepatic and systemic immune response. Given the close association between PSC and inflammatory bowel disease (IBD), the microbiota represents an important factor in the development of PSC. Bile acid based pharmacological treatments could represent promising therapeutic strategies in the management of cholangiopathies.SummaryCholangiopathies include a spectrum of diseases resulting in cholestasis, an impairment of bile flow in the biliary tree, leading to biliary obstruction and damage as well as liver inflammation and fibrosis. PSC and PBC are highly heterogeneous cholangiopathies and progressive disorders with defined pathophysiological mechanisms. Curative treatments have not been established, and although their prevalence is low, they are a frequent indication for liver transplantation in the advanced stages of cholangiopathies. These diseases still present with unmet therapeutic strategies, also taking into account that on average 30-40% of patients undergoing liver transplantation will have recurrence of the original illness
Tissue-specific actions of FXR in metabolism and cancer.
No full textThe nuclear Farnesoid X Receptor (FXR) is a transcription factor critically involved in metabolic homeostasis in the gut-liver axis. FXR activity is mediated by hormonal and dietary signals and driven by bile acids (BAs), which are the natural FXR ligands. Given the great physiological importance in BA homeostasis, as well as in the regulation of glucose and lipid metabolism, FXR plays a pivotal role in the pathogenesis of a wide range of disease of the liver, biliary tract and intestine, including hepatic and colorectal cancer. In the last years several studies have shown the relative FXR tissue-specific importance, highlighting synergism and additive effects in the liver and intestine. Gain- and loss-of-FXR-function mouse models have been generated in order to identify the biological processes and the molecular FXR targets. Taking advantage of the knowledge on the structure-activity relationship of BAs for FXR, semi-synthetic and synthetic molecules have been generated to obtain more selective and powerful FXR activators than BAs. This article is part of a Special Issue entitled: Linking transcription to physiology in lipodomics
AKT activation may represent the molecular link between rapamycin (RAPA) treatment and insulin-resistance in renal transplant recipients.
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