1,721,202 research outputs found
PTPN3 Mutations and HBV May Exert Synergistic Effects in the Origin of the Intrahepatic Cholangiocarcinoma
No full text[No abstract available
Environmental Contribution to Pathogenesis of Cyst Formation in Autosomal-Dominant Polycystic Liver Diseases
No full text[No abstract available
Intervento reatino "Rete WiFi"
No full textA seguito di una sequenza sismica nell’area reatina (settembre 2010) si è deciso di installare una rete temporanea che potesse aumentare in quell’area il numero di stazioni in tempo reale.INGVPublishedRoma1.1. TTC - Monitoraggio sismico del territorio nazionaleope
Multilevel heterogeneity of biliary tract cancers may affect the modelling of prognosis
No full textCholangiocarcinoma (CCA) multilevel heterogeneity may affect the modelling of prognosis, and, indeed, the possibility to define pre- operative survival was limited until recently. Schweitzerl et al1 devel-oped and validated a novel pre- operative clinical prognostic model for patients treated for biliary tract cancers (BTCs) including intrahepatic CCA, extrahepatic CCA and gallbladder cancer (GC). The prognostic score distinguished three groups of patients with a median OS of 21.8, 8.6 and 2.6 months respectively. The prognostic impact of the score was independent of treatment procedures and the tumour site
Multiple cells of origin in cholangiocarcinoma underlie biological, epidemiological and clinical heterogeneity.
No full textRecent histological and molecular characterization of cholangiocarcinoma (CCA) highlights the heterogeneity of this cancer that may emerge at different sites of the biliary tree and with different macroscopic or morphological features. Furthermore, different stem cell niches have been recently described in the liver and biliary tree, suggesting this as the basis of the heterogeneity of intrahepatic (IH)- and extrahepatic (EH)-CCAs, which are two largely different tumors from both biological and epidemiological points of view. The complexity of the organization of the liver stem cell compartments could underlie the CCA clinical-pathological heterogeneity and the criticisms in classifying primitive liver tumors. These recent advances highlight a possible new classification of CCAs based on cells of origin and this responds to the need of generating homogenous diagnostic, prognostic and, hopefully, therapeutic categories of IH- and EH-CCAs
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