1,721,025 research outputs found

    Ipertensione portale e sue complicanze: emorragia da varici esofagee e sindrome epatorenale. Stato dell'arte. Moderatore seconda sessione

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    Relazioni su clinica e trattamento delle emorragie del tratto digestivo alto da ipertensione portale e su fisiopatologia e terapia della s.epatorenale

    Treatment of hepatitis C in hemophiliacs.

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    Hepatitis C virus (HCV) infection is a major cause of morbidity and mortality in hemophiliacs who received nonvirucidally treated large-pool clotting factor concentrates before 1986. In fact, although many hemophiliacs infected with HCV have a slow progression of liver disease, in a minority of them hepatitis evolves toward end-stage liver disease and hepatocarcinoma. Moreover, a significant percentage of HCV-infected hemophiliacs were also coinfected with human immunodeficiency virus (HIV), which can accelerate the progression of liver disease. Thus, the aim of anti-HCV therapy is to interrupt the chronic infection in order to prevent the progression of hepatitis to cirrhosis, liver decompensation, cancer and, ultimately, death. In this review we present the literature data on anti-HCV treatment in hemophiliacs. Combination therapy with interferon (IFN) and ribavirin has improved the poor results obtained with IFN monotherapy and has become the standard treatment of chronic hepatitis C. Given the positive results obtained with pegylated interferon plus ribavirin in nonhemophiliacs, ongoing trials are evaluating this promising therapy in HCV-chronically infected hemophilic patients; preliminary results show a sustained response rate similar to that in patients without coagulopathy. Finally, based on the encouraging results in coinfected nonhemophiliacs, anti-HCV treatment should also be considered for those HIV-positive hemophiliacs in whom anti-retroviral treatment has stabilized the HIV infection

    Quelle due o tre tazze di tè verde: caso clinico.

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    Una signora si reca in Pronto soccorso per dolore epi-mesogastrico associato a nausea di cui soffre da qualche mese. Si riscontra un incremento delle ALT e un lieve aumento della bilirubina totale. La donna nega l’assunzione recente e/o continua di farmaci, ma dichiara l’assunzione quotidiana di due o tre tazze di infusi di tè verde. Gli esami sierologici risultano negativi e l’analisi istologica documenta un danno “tossico” da farmaci. Alla sospensione dell’assunzione del tè verde, i parametrici epatici rientrano

    [Therapy of idiopathic thrombocytopenic purpura: the role of human immunoglobulins]

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    trattamento con immunoglobuline e.v. ad alte dosi per porpora trombocitopenica idiopatic

    Relationship between ABO blood group and Von Willebrand factor levels: from biology to clinical implications.

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    A number of studies demostrated the influence of ABO blood group on plasma levels of Von Willebrand factor but the nature of this association is still largely unknown. In this paper we discussed the recent advances in understanding the mechanisms by which ABO blood group determines plasma VWF levels and their clinical impact

    Pulmonary mucosa-associated lymphoid tissue lymphoma and myasthenia gravis. A case report.

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    A case of MALT-lymphoma with multiple large opacities involving both the lungs in a woman suffering from myasthenia gravis
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