1,721,591 research outputs found
Extracellular vesicles in cancer pros and cons: The importance of the evidence-based medicine
No full textIn this paper we want to introduce a hot topic for clinical and translational research in oncology and all the related medical fields: the "exosomology", i.e., the science that looks at exosomes as nanovesicular tools for theranostics. Exosomes are extracellular vesicles (EVs) of nanometric sizes actively secreted by normal and, above all, tumor cells. Among the EVs, exosomes are surely the most investigated and with the most promising results, mainly for what concerns their potential as representing the future of the so-called "liquid biopsy". Unfortunately, the huge and increasing amount of data coming from preclinical studies was not followed by an adequate number of clinical investigations. However, those clinical studies published to date have provided encouraging but probably unexpected results, including the clinical relevance of the exosome plasmatic levels and the overexpression of well-known biomarkers on the circulating EVs. The clinical relevance of exosomes as a source of new tumor biomarkers (e.g., proteins and miRNA) has been sufficiently supported by clear data.We here want to provide our viewpoint about the existing clinical results based on the literature and our own experience to trigger discussion aimed at undertaking a new direction for future investigation on a role of exosomes in cancer diagnosis and treatment. We believe that a more strategic co-operation between the com-munity of basic scientists and the clinical oncologists should be generated soon, in order to investigate the relevance of the impressive amount of data obtained in human tumor cell lines and animal models. For sure we need a more strategic behavior but also a far-sighted scientific investment in a field where nothing should be considered as granted; a field where we need a mutual collaboration between basic science, clinicians, gov-ernments and of course industry
VirDe: A new virtual reality design approach
No full textVirtual reality (VR), even if it does not represent
any more a novel technology, is one of the most powerful
tool to help designers during the development of new pro-
jects. This is proved by very numerous research activities
related to this field. In this research, we have studied a new
way to approach the development of a product. We present
the ongoing development of a system, called VirDe, acronym
of virtual design, which can allow the designers to perform
the whole design process, from the modelling phase to the
finite element method (FEM) simulation analysis, in a vir-
tual reality environment. This newmethod allows remarkable
time andmoney saving in the overall product design process,
but the most important contribution of VirDe is that, as far as
we concerned, there is no known similar approach which has
been studying the simultaneous combination of CAD, FEM
and virtual environment (VE)
Design and Manufacturing of Automotive Structures Using Composite Materials (Special Issue of the International Journal of Vehicle Design)
No full text
- …
