1,721,010 research outputs found
Ultrastructural and biochemical studies on mast cell exocytosis induced by adriamycin at different temperatures
No full textPhysiological regulation pf P-glycoprotein, MRP1, MRP2 and cytochrome P450 3A2 during rat ontogeny
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Human recombinant interferon alpha-2a inhibits mast cell-induced angiogenesis in the chick embryo chorioallantoic membrane
No full textDegranulation and adriamycin uptake in beige mice mast cells with giant secretory granules
No full textImmunochemical and immuno-electron microscopical identification of P-170 in rat peritoneal mast cells
No full textToxicity of Hypericum perforatum (St. John's wort) administered during pregnancy and lactation in rats.
No full textThe popularity of St. John's wort (Hypericum perforatum) for the treatment of depression is increasing and, in recent years, concerns about its use during pregnancy and breastfeeding have emerged. The purpose of this study was to investigate, in Wistar rats, the effects of a treatment with hypericum administered prenatally and during breastfeeding (from 2 weeks before mating to 21 days after delivery). Two doses of the extract were chosen, 100 mg/kg per day, which, based on surface area, is comparable to the dose administered to humans, and 1000 mg/kg per day. A microscopical analysis of livers, kidneys, hearts, lungs, brains, and small bowels was performed. A severe damage was observed in the livers and kidneys of animals euthanized postnatally on days 0 and 21. The lesions were more severe with the higher dose and in animals that were breastfed for 21 days; however, an important renal and hepatic damage was evident also with the dose of 100 mg/kg per day. In addition, similar serious hepatic and renal lesions were evident also in animals that were exposed to hypericum only during breastfeeding. In particular, a focal hepatic damage, with vacuolization, lobular fibrosis, and disorganization of hepatic arrays was evident; in the kidney, a reduction in glomerular size, disappearance of Bowman's space, and hyaline tubular degeneration were found. The results obtained in this study indicate that further, appropriate histological studies should be performed in other animal species to better evaluate the safety of hypericum extracts taken during pregnancy and breastfeeding
Efficiency of doxorubicin handling by isolated hepatocytes is a valuable indicator for restored cell function
No full textDoxorubicin fluorescence staining of isolated hepatocytes. A simple and valuable indicator for restored cell function
No full textBiochemical and microscopic evidence for the internalization of drug-containing mast cell granules by macrophages and smooth muscle cells
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