174,624 research outputs found
Shelf-slope exchanges associated with a steep submarine canyon off Calvi (Corsica, NW Mediterranean Sea): A modelling approach
No full textpeer reviewedA three-dimensional, unsteady, nonlinear, high-resolution model is used to investigate the impact of the Calvi Canyon (NW Corsica) steep topography on the shelf-slope exchanges as well as on the circulation in the Calvi Bay in homogeneous winter and early spring conditions. A double σ coordinate system is considered in order to represent adequately the high depth gradients within the canyon. The studied region is under the influence of the West Corsica Current flowing northeastward along the NW Corsican coast (right-bounded flow). Model results show that the circulation in the Calvi Bay is determined by flow modifications in the canyon area. The mean horizontal flow is deviated southwestward upstream of the canyon to form an anticyclonic gyre in the western part of the Calvi Bay. Within the canyon the circulation is cyclonic leading to an offshore flow downstream of the canyon. Around the canyon rim, the cross-shelf currents become important, indicating that this region acts as a transition zone of high exchange between nearshore and offshore areas. Furthermore, the canyon topography generates high downwelling (upwelling) and downsloping (upsloping) velocities responsible for an intense vertical transport of material in the area. Numerical runs are performed for typical prevailing wind conditions. The wind is responsible for a drastic increase of cross-shore transports between the bay and the canyon area (3–4 times larger than in the no-wind case). SW winds induce a further enhancement of cross-shelf exchanges, whereas the effect of N-NE winds is to reduce exchange at the shelf break apart from the canyon head where an intense offshore flow occurs. Within the canyon, high vertical velocities are shown to be associated with high cyclonic vorticity which is enhanced (reduced) by the N-NE (SW) wind event. A comparison between model results and measured distributions of nitrate and chlorophyll a concentrations in the area shows the role played by this specific hydrodynamics as a strong constraint on the coastal pelagic ecosystem
Supplemental Material for Herriage and Calvi, 2024
No full textSupplemental Figures for Herriage and Calvi: Premature endocycling of Drosophila follicle cells causes pleiotropic defects in oogenesis</p
Swimming Pool [A. Calvi]
No full textTitre de la chanson : Swimming Pool Auteur : Anna Calvi (*1980) Interprète : Anna Calvi Titre de l'album : Hunter (piste 5) Durée de la piste : 4'54 Label : Domino Recording Company Année : 2018 Pays : Royaume-Uni Genre : chanson anglophone Texte de la chanson : Oh, oh, ohThe swimming poolOh, oh, ohThe swimming pool Shadows of lightShadows divide on the earthCome down to the swimming pool Waves of desireWaves of desire on the earthCome down to the swimming pool I can be the oneIf you c..
Insights into Discourse Markers: Cognition and Acquisition
No full textThis volume employs a range of empirical methodologies – including eyetracking, direct observation, qualitative research and corpus analysis – to describe the use of discourse markers in second language acquisition. The variety of different approaches used by the contributors facilitates the observation of correlations between morphosyntactic, semantic and pragmatic features of discourse markers and enriches our understanding of the cognitive behaviour of L2 speakers, both in the understanding and production of texts. Some of the essays examine the acquisitional paths of discourse markers in instructional and natural contexts, with a particular focus on situations of language contact and social integration; others describe experimental studies that analyse the cognitive processing of discourse markers in L2 learners. All the contributions aim to offer new insights which will expand and develop existing theoretical claims about this area of study and open up avenues for further research
Driver’s perceived discomfort and road safety
No full textRoad geometry and traffic conditions influence strongly drivers behaviour.
The authors propose a model for the evaluation of driver’s level of discomfort LD locally induced by different road environments and traffic flow conditions. The main theoretical hypothesis behind the model is that a significant indicator of the level of discomfort is computed as proportional to the difference between driver’s desired speed Sd and the operating speed So imposed by local traffic density. To evaluate the level of discomfort for an homogeneous road segment, the variation of road characteristics and traffic conditions in terms of flow and composition must be taken into account. Moreover driver’s desired speed depends on the individual reason of the travel.
Therefore, considering a traffic condition, the level of discomfort at a specific road location will assume different value for each flow typology. The greater the difference between driver’s desired speed and flow speed, the higher the level of discomfort.
Twenty-five Italian rural two way-two lane road segments have been analysed. Field surveys were needed for data collection. The discrepancies between drivers expectations and operating conditions have been analysed. These data have been correlated with road dependent collisions of each road segment.
This paper shows the results and points out the validity and applicability of the model to actual case studies for the evaluation of the expected accident occurrence as a function of the level of discomfort suffered by road users
Activation of protein C in human trophoblasts in culture and downregulation of trophoblast endothelial protein C receptor by TNF-α
No full textIn mice, trophoblasts are equipped with a potent anticoagulant mechanism, the protein C pathway. In human placenta, no functional studies of the protein C pathway are available. Human first-trimester trophoblasts (CK++ HLA-G(+/-) Vim(-) ) were isolated and kept in culture for a maximum of 48 hours. Activation of protein C on trophoblasts was at least as efficient as in endothelial cells (4.43 x 10 (-) (7) nmol/L/min/cell). Endothelial protein C receptor (EPCR) was expressed in syncytiotrophoblasts and extravillous trophoblasts. Downregulation of the messenger RNA of trophoblast EPCR occurred when trophoblasts were challenged with tumor necrosis factor , and it could be prevented by unfractionated heparin but not by low-molecular-weight heparin at therapeutic doses. In conclusion, there is a functional protein C pathway on human first-trimester trophoblasts which can be modulated by inflammation. This finding has implications for the pathogenesis and prevention of placenta-mediated obstetric complications
PP1 phosphatases control PAR-2 localization and polarity establishment in C. elegans embryos
No full textCalvi et al manuscript dat
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