1,720,975 research outputs found
Computer navigation versus conventional implantation for varus knee total arthroplasty: a case-control study at 5 years follow-up.
No full textBackground: There is no evidence in the current literature of any significant improvement in clinical outcome when comparing computer-assisted
total knee arthroplasty (CATKA) with conventional implantation. Analyses of alignment and of component orientation have shown both
significant and non-significant differences between the two methods.
Objectives: We compared computer-assisted and conventional surgery for TKA at 5.4 years follow-up for patients with varus osteoarthritic knees.
Our goal was to assess clinical outcome and restoration of normal limb alignment.
Materials and methods: We performed a retrospective case-control study comparing 30 patients who underwent CATKA with 30 subjects who
underwent TKA by conventional methods. Patients were matched individually by preoperative clinical conditions and alignment. We analysed
intraoperative data (surgical time and intraoperative complications), postoperative complications, lower limb alignment, radiographic complication
on X-ray imaging, and clinical outcome through knee and function score and range of motion.
Results and discussion: We found no significant clinical difference between the two groups at 5 years post-surgery. However there was a
statistically significant improvement in the restoration of the mechanical axis of the lower limb in the coronal plane but not in the sagittal plane.
Whether or not this leads to a higher survival rate in the longer term requires further investigation
Clinical and forensic medicine issues in osteoporosis fractures.
No full textSevere osteoporosis is characterized by a densitometry T-score lower than 2.5 associated with one or more fragility fractures. Fragility fractures represent a serious social and economic problem; the diagnosis of osteoporosis is an unachieved target by orthopaedic surgeons, despite the chance to detect it in many clinical assets and the availability of effective treatment tools. It is necessary to stick to scientific society guidelines, thus avoiding legal consequences related to the diagnosis, the therapy, the prescription coherence and the correct information due to patients
Mechanobiology and pathology of hyaline articular cartilage: from cellular to molecular therapy.
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Evidenze nella biomeccanica delle fratture della regione trocanterica e dei relativi mezzi di sintesi
No full textEpigenetics in Knee Osteoarthritis: A 2020–2023 Update Systematic Review
No full textOsteoarthritis is a leading cause of disability in the world. The scientific literature highlights the critical importance of epigenetic regulatory effects, intertwined with biomechanical and biochemical peculiar conditions within each musculoskeletal district. While the contribution of genetic and epigenetic factors to knee OA is well-recognized, their precise role in disease management remains an area of active research. Such a field is particularly heterogeneous, calling for regular analysis and summarizing of the data that constantly emerge in the scientific literature, often sparse and scant of integration. The aim of this study was to systematically identify and synthesize all new evidence that emerged in human and animal model studies published between 2020 and 2023. This was necessary because, to the best of our knowledge, articles published before 2019 (and partly 2020) had already been included in systematic reviews that allowed to identify the ones concerning the knee joint. The review was carried out in accordance with Preferential Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Only peer-reviewed articles were considered for inclusion. A total of 40 studies were identified, showing promising results in terms either of biomarker identification, new insight in mechanism of action or potential therapeutic targets for knee OA. DNA methylation, histone modification and ncRNA were all mechanisms involved in epigenetic regulation of the knee. Most recent evidence suggests that epigenetics is a most promising field with the long-term goal of improving understanding and management of knee OA, but a variety of research approaches need greater consolidation
Total knee arthroplasty clinical outcame evaluation through subject-specific kinematics applied to finete element model.
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