296 research outputs found
The role of ivabradine in diastolic heart failure with preserved ejection fraction. A doppler-echocardiographic study
No full textBackground: Ivabradine (IVA) is effective in patients with coronary artery disease (CAD) or systolic heart failure in sinus rhythm. Its action consists in reducing heart rate (HR) and improving the time of left ventricular (LV) diastolic filling. The aim of this study was to evaluate the effects of IVA added to conventional therapy on patients with diastolic heart failure (DHF) and preserved ejection fraction (HFpEF). Methods: We evaluated 25 patients with DHF in the New York Heart Association (NYHA) Class II-III and sinus rhythm. In these, IVA per os (5 mg/twice a day) was added to the conventional medical therapy and given for 12 weeks. Immediately before the beginning of IVA therapy and 3 months later, patients underwent echocardiographic evaluation by two-dimensional (2D) ultrasound and tissue Doppler imaging (TDI). The patterns of diastolic mitral inflow and pulmonary venous flow were recorded using 2D echocardiography, while the diastolic phase of mitral flow was recorded by TDI, from the lateral mitral annulus. Results: Three months after the addition of IVA to conventional treatment, HR significantly decreased in comparison to the baseline values. On the contrary, the echocardiographic indexes of LV diastolic dysfunction improved. Conclusions: These results testify that the addition of IVA to conventional therapy in patients with HFpEF can improve LV diastolic function evaluated by 2D and tissue Doppler-echocardiographic patterns. These Doppler-echocardiographic results match with the clinical improvement of patients evaluated
Resistant hypertension in elderly patient with nephropathy in primary and secondary care settings
No full textResistant hypertension is defined as a blood pressure above therapeutic goals, despite the concurrent use of three or more antihypertensive drugs of different pharmacological classes, and all being administered according to an optimum dosage schedule. The prevalence of resistant hypertension in the older people has not yet been exactly quantified. The updated available estimates deriving from some clinical trials report a prevalence of approximately 20-30% of all hypertensive patients. Advanced age seems to be an important risk factor in resistant forms of high blood pressure. Therefore this clinical condition may potentially increase in the coming years. Chronic kidney disease is the most frequent comorbidity associated with resistant hypertension and often leads to poor prognosis. The article describes a case report of an older subject with such a clinical condition suggesting diagnostic and therapeutic plan based on a rational strategy to control hypertension and the most recent knowledge reported in the medical literature
Post-necrotic left ventricular dysfunction in diabetes mellitus: effects of Trimetazidine
No full text5'-methylthioformycin, a new structural analog of 5'-methylthioadenosine: effect on the enzymes of polyamine metabolism
No full text[S-adenosyl(5')-3-methylthiopropylamine as substrate and inhibitor of S-adenosylmethionine lyase from rat liver]
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Analogs of 5'-deoxy-5'-methylthioadenosine modified in the purine ring: new synthetic procedure and effect on 5'-methylthioadenosine phosphorylase
No full textTRATTAMENTO DELLA DEMENZA IN PAZIENTE PORTATORE DI PACEMAKER, TRA DUBBI E RAGIONEVOLEZZA SCIENTIFICA
No full textHigh-performance liquid chromatographic analysis of adenosyl-sulfur compounds related to polyamine biosynthesis
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