113,553 research outputs found
Thermoresponsive Behaviors of Poly(oxypropylene)-amidoamine Functionalized Carbon Nanotubes
No full textA functional variant in the promoter region regulates the C-reactive protein gene and is a potential candidate for increased risk of atrial fibrillation
No full text. Chang S-N, Tsai C-T, Wu C-K, Lee J-K, Lai L-P, Huang S-W, Huang L-Y, Tseng C-D, Lin J-L, Chiang F-T, Hwang J-J (National Taiwan University Hospital Yun-Lin Branch, Yun-Lin; National Taiwan University Hospital, Taipei; National Taiwan University Hospital, Taipei; Institute of Pharmacology, Taipei; and Graduate Institute of Biomedical Engineering, Taipei, Taiwan). A functional variant in the promoter region regulates the C-reactive protein gene and is a potential candidate for increased risk of atrial fibrillation. J Intern Med 2012; 272: 305315. Objectives. In a large population-based cohort, the level of C-reactive protein (CRP) in patients at baseline predicts an increased risk of future development of atrial fibrillation (AF). The mechanism of this increased risk is unknown. Furthermore, both the molecular effects of CRP on atrial myocytes and fibroblasts and whether genetic variants in the CRP gene predispose to AF are also unknown. Methods.similar to A genetic association study between CRP gene polymorphisms and AF was performed in two independent populations (I: 100 AF patients and 101 controls; II: 348 AF patients and 356 controls), with functional studies to elucidate the mechanism of association. Results.similar to Three polymorphisms (T-861C, A-821G and C-390A/C-390T) were found in the 1-kb promoter of CRP. A triallelic polymorphism (C-390A/C-390T) captured all haplotype information and determined the CRP gene promoter activity and the plasma CRP level, and was in nearly complete linkage disequilibrium with G1059C polymorphism in exon 2. The -390A variant was associated with a higher CRP gene promoter activity, a higher plasma CRP level and a higher risk of AF. Patients with AF also had a higher plasma CRP level than controls. CRP significantly increased the inward L-type calcium current in atrial myocytes with no changes in other ionic currents. CRP did not affect the expressions of type I alpha 1 (COL1A1), type III alpha 1 (COL3A1) and type 1 alpha 2 (COL1A2) procollagens in atrial fibroblasts. Conclusion.similar to A CRP gene promoter triallelic polymorphism was associated with CRP gene promoter activity, determined the plasma level of CRP, and predicted the risk of AF. The mechanism of this may be via augmention of calcium influx by CRP in atrial myocytes, but not because of atrial fibrosis
Study of B c + → J / ψ D s + and B c + → J / ψ D s ∗ + decays in pp collisions at √s = 13 TeV with the ATLAS detector
No full textA study of B+
c → J/ψD+
s and B+
c → J/ψD∗+
s decays using 139 fb−1 of integrated luminosity collected with the ATLAS detector from √
s = 13 TeV pp collisions
at the LHC is presented. The ratios of the branching fractions of the two decays to the
branching fraction of the B+
c → J/ψπ+ decay are measured: B(B+
c → J/ψD+
s
)/B(B+
c →
J/ψπ+) = 2.76 ± 0.47 and B(B+
c → J/ψD∗+
s
)/B(B+
c → J/ψπ+) = 5.33 ± 0.96. The ratio
of the branching fractions of the two decays is found to be B(B+
c → J/ψD∗+
s
)/B(B+
c →
J/ψD+
s
) = 1.93 ± 0.26. For the B+
c → J/ψD∗+
s decay, the transverse polarization fraction,
Γ±±/Γ, is measured to be 0.70 ± 0.11. The reported uncertainties include both the statistical and systematic components added in quadrature. The precision of the measurements
exceeds that in all previous studies of these decays. These results supersede those obtained
in the earlier ATLAS study of the same decays with √s = 7 and 8 TeV pp collision data. A
comparison with available theoretical predictions for the measured quantities is presented
Growth and production ofγ-decalactone by Sporobolomyces odorus in jar fermentors as affected by pH, aeration and fed-ba_TTS.DATE
No full textEffect of the Laminate Configuration on the Modulus of Elasticity of Glulam Evaluated using a Strain Gauge Method
No full textAnalysis of the involvement of chitin-binding domain of ChiCW in antifungal activity, and engineering a novel chimeric chitinase with high enzyme and antifungal activities
No full textMammalian LIN-7 PDZ proteins associate with beta-catenin at the cell junctions of epithelia and neurons
No full textThe heterotrimeric PDZ complex containing LIN-2, LIN-7 and LIN-10 is known to be involved in the organization of epithelial and neuronal junctions in Caenorhabditis elegans and mammals. We report here that mammalian LIN-7 PDZ proteins form a complex with cadherin and β-catenin in epithelia and neurons. The association of LIN-7 with cadherin and β-catenin is Ca2+ dependent and is mediated by the direct binding of LIN-7 to the C-terminal PDZ target sequence of β-catenin, as demonstrated by means of co-immunoprecipitation experiments and in vitro binding assays with the recombinant glutathione S-transferase:LIN-7A. The presence of β-catenin at the junction is required in order to relocate LIN-7 from the cytosol to cadherin-mediated adhesions, thus indicating that LIN-7 junctional recruitment is β-catenin dependent and that one functional role of the binding is to localize LIN-7. Moreover, when LIN-7 is present at the β-catenin-containing junctions, it determines the accumulation of binding partners, thus suggesting the mechanism by which β-catenin mediates the organization of the junctional domai
Assembly statistics for <i>S</i>. <i>lin</i>. <i>J</i> and <i>S</i>. <i>glomerata</i> transcriptomes.
No full textAssembly statistics for S. lin. J and S. glomerata transcriptomes.</p
- …
