38,281 research outputs found
Exact Maximum Likelihood estimation for the BL-GARCH model under elliptical distributed innovations
No full textIn this paper, we discuss the class of Bilinear GATRCH (BL-GARCH) models which are capable of capturing simultaneously two key properties of non-linear time series : volatility clustering and leverage effects. It has been observed often that the marginal distributions of such time series have heavy tails ; thus we examine the BL-GARCH model in a general setting under some non-Normal distributions. We investigate some probabilistic properties of this model and we propose and implement a maximum likelihood estimation (MLE) methodology. To evaluate the small-sample performance of this method for the various models, a Monte Carlo study is conducted. Finally, within-sample estimation properties are studied using S&P 500 daily returns, when the features of interest manifest as volatility clustering and leverage effects.BL-GARCH process, elliptical distribution, leverage effects, Maximum Likelihood, Monte Carlo method, volatility clustering.
BL-70 RNA-Seq reads from the Taxonomer virus bin assigned to virus species or genera.
No full textBL-70 RNA-Seq reads from the Taxonomer virus bin assigned to virus species or genera.</p
Convergences in perfect BL-algebras
No full textThe aim of the paper is to investigate some concepts of convergence in the class of
perfect BL-algebras. Similarity convergence was developed by G. Georgescu and A. Popescu in
the case of the residuated lattices, while the convergence with a fixed regulator was studied
by Cernák for lattice-ordered groups and MV-algebras and by the author for residuated lattices. In this paper we study the similarity convergence and the convergence with a fixed regulator for the perfect BL-algebras. The main result is the construction of Cauchy completion of a perfect BL-algebra.Peer Reviewe
Protein and Chemical Determinants of BL-1249 Action and Selectivity for K 2P Channels
No full textK 2P potassium channels generate leak currents that stabilize the resting membrane potential of excitable cells. Various K 2P channels are implicated in pain, ischemia, depression, migraine, and anesthetic responses, making this family an attractive target for small molecule modulator development efforts. BL-1249, a compound from the fenamate class of nonsteroidal anti-inflammatory drugs is known to activate K 2P 2.1(TREK-1), the founding member of the thermo- and mechanosensitive TREK subfamily; however, its mechanism of action and effects on other K 2P channels are not well-defined. Here, we demonstrate that BL-1249 extracellular application activates all TREK subfamily members but has no effect on other K 2P subfamilies. Patch clamp experiments demonstrate that, similar to the diverse range of other chemical and physical TREK subfamily gating cues, BL-1249 stimulates the selectivity filter "C-type" gate that controls K 2P function. BL-1249 displays selectivity among the TREK subfamily, activating K 2P 2.1(TREK-1) and K 2P 10.1(TREK-2) ∼10-fold more potently than K 2P 4.1(TRAAK). Investigation of mutants and K 2P 2.1(TREK-1)/K 2P 4.1(TRAAK) chimeras highlight the key roles of the C-terminal tail in BL-1249 action and identify the M2/M3 transmembrane helix interface as a key site of BL-1249 selectivity. Synthesis and characterization of a set of BL-1249 analogs demonstrates that both the tetrazole and opposing tetralin moieties are critical for function, whereas the conformational mobility between the two ring systems impacts selectivity. Together, our findings underscore the landscape of modes by which small molecules can affect K 2P channels and provide crucial information for the development of better and more selective K 2P modulators of the TREK subfamily
The development of accounts for private households to c.1500 A.D.
No full textSIGLEAvailable from British Library Document Supply Centre- DSC:D95504 / BLDSC - British Library Document Supply CentreGBUnited Kingdo
Comparative studies on cytotoxic and genotoxic effects of two organic mercury compounds in lymphocytes and gastric mucosa cells of Sprague-Dawley rats
No full textHuman lymphocytes (HL) as well as lymphocytes (RL), hepatocytes (RH), and gastric mucosa cells (GM) of Sprague-Dawley rats were treated in vitro for 1 h with methylmercury chloride (MMC, 0.5-4 mug/ml) and dimethylmercury (DMM, 5-40 mug/ml). The cytotoxicity of the two organic mercury compounds was assessed by dye exclusion, and the extent of induced DNA fragmentation was measured with a single-cell microgel electrophoresis assay. Both MMC and DMM induced DNA damage and cytotoxicity in a dose-related manner in HL, RL, and GM. MMC was more effective in causing o significant increase in median DNA migration than DMM at doses yielding approximately the same degree of cytotoxicity. In rat hepatocytes the MMC-induced DNA damage was, however, lower than in the other cells. An analysis of repair kinetics following exposure to 2 mug/ml MMC was carried out in human lymphocytes obtained from an adult male donor. The bulk of DNA repair occurred 90 min after in vitro exposure, and it was about complete by 120 min following cessation of exposure. Finally, in order to have a basis for extrapolating to the human situation, in vivo studies were performed with Sprague-Dawley rats, also assessing the DNA damage and cytotoxicity in the lymphocytes and gastric mucosa cells. These in vivo results after oral exposure may be directly compared to the in vitro data obtained in the same cells
[Stammbuch C. B. Meltzer] / C. B. Meltzer
No full text[STAMMBUCH C. B. MELTZER] / C. B. MELTZER
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Disk-jet connection in BL lac objects with different accretion modes
No full textThe maximal jet power can be extracted from a standard thin accretion disk/spinning black hole is calculated as a function of dimensionless accretion rate m (m = M/M-Edd). Comparing with the jet power derived from the extended radio luminosity, we find that the accretion disks in most BL Lac objects should not be standard accretion disks. It is found that a pure ADAF is too faint to produce the optical ionizing luminosity of BL Lac objects derived from their narrow-line luminosity. We propose that an ADAF is present in the inner region of the disk and it transits to a standard thin disk outside the radius R-tr in most BL Lac objects, i.e., ADAF+SD (standard disk) scenario. This scenario can explain both the jet power and optical ionizing continuum emission of these BL Lac objects. The inferred R-tr similar to 40 - 150 GM(bh)/c(2), if the disks are accreting at the rate m = 0.01
[Stammbuch C. L. Rubach] / C. L. R.
No full text[STAMMBUCH C. L. RUBACH] / C. L. R.
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[Stammbuch C. Voges]
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