489 research outputs found
Architect Antonín Tenzer
No full textThe work of Antonin Tenzer involves his activities in the period of six decades in the turbulent era of development of Czechoslovak history of architecture. The architect is known as one of the representatives of the avant-garde and High functionalism, author of Faculty Hospital in Prague-Motol and other medical buildings or the Jalta hotel, a building associated with socialist realism. In my dissertation, I tried to map the main typological fields that Antonín Tenzer used in his work. My goal was to widen the portfolio of famous buildings, and on the basis I defined the architect's major themes and current issues, which were responded in his effort. I based primarily on historic materials - published projects, plan documentation and writings of public and private archives, as well as personal heritage, made available to me by the architect's family. In particular thematic areas I focused on Tenzer's vital and successful implementation of competition projects, which he later followed and extended. In addition to impulses from his collaborators, debates and majors works of those days I was looking for elements and methods of Tenzer that influenced the architecture environment. I observed the influence of historical events and the socio-political situation in his work, for example, housing issues in..
Henri Temianka Correspondence; (tenzer)
No full textThis collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/4202/thumbnail.jp
Henri Temianka Correspondence; (tenzer)
No full textThis collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/4204/thumbnail.jp
Henri Temianka Correspondence; (tenzer)
No full textThis collection contains material pertaining to the life, career, and activities of Henri Temianka, violin virtuoso, conductor, music teacher, and author. Materials include correspondence, concert programs and flyers, music scores, photographs, and books.https://digitalcommons.chapman.edu/temianka_correspondence/4203/thumbnail.jp
IDENTIFICATION OF MICROSATELLITE MARKERS AND THEIR APPLICATION TO POPULATION GENETICS OF VENTURIA INAEQUALIS
No full textWide field imager instrument for the Advanced Telescope for High Energy Astrophysics
No full textThe Advanced Telescope for High Energy Astrophysics (Athena) has been selected for ESA's L2 mission, scheduled for launch in 2028. It will provide the necessary capabilities to achieve the ambitious goals of the science theme "The Hot and Energetic Universe." Athena's X-ray mirrors will be based on silicon pore optics technology with a 12-m focal length. Two complementary focal plane camera systems are foreseen, which can be moved interchangeably to the focus of the mirror system: the actively shielded micro-calorimeter spectrometer X-IFU and the wide field imager (WFI). The WFI camera will provide an unprecedented survey power through its large field of view of 40 arc min with a high count-rate capability (∼1 Crab). It permits a state-of-the-art energy resolution in the energy band of 0.1 to 15 keV during the entire mission lifetime (e.g., full width at half maximum ≤150 eV at 6 keV). This performance is accomplished by a set of depleted P-channel field effect transistor (DEPFET) active pixel sensor matrices with a pixel size well suited to the angular resolution of 5 arc sec (on-axis) of the mirror system. Each DEPFET pixel is a combined detector-amplifier structure with a MOSFET integrated onto a fully depleted 450-μm-thick silicon bulk. This manuscript will summarize the current instrument concept and design, the status of the technology development, and the envisaged baseline performance
Investigation of coupled hydraulic-geomechanical processes at the KTB site: pressure-dependent characteristics of a long-term pump test and elastic interpretation using a geomechanical facies model
No full textThe German Continental Deep Drilling Program comprising a pilot borehole down to 4000 m and a main borehole down to 9101 m in southeast Germany (KTB) is continuing to provide a unique opportunity for the identification of important factors and processes in deep-seated fluid and energy transfer. In situ stress conditions significantly impact flow, transport and exchange characteristics of fracture networks that dominate the permeability of crystalline reservoir rocks. In this paper, several scales of information are combined to present a fully three-dimensional hydraulic finite element model of the principal KTB fault zones, and linked to a geomechanical model describing the alteration of the hydraulic parameters with stress changes caused by fluid extraction. The concept of geomechanical facies is introduced to define and characterize architectural elements in the subsurface system. Evaluation of a long-term pump test in the KTB pilot hole, June 2002-July 2003, coupled with a geomechanical model gives an insight into some of the elastic and nonelastic processes controlling hydraulic transport in the basement rocks. Trends in the decline of the permeability and the degree of storage in the system could only partially be explained by elastic processes, clearly indicating the importance of nonelastic processes. A number of inelastic processes are suggested as areas for further research
Author response
No full textMyelination of axons facilitates rapid impulse propagation in the nervous system. The axon/myelin-unit becomes impaired in myelin-related disorders and upon normal aging. However, the molecular cause of many pathological features, including the frequently observed myelin outfoldings, remained unknown. Using label-free quantitative proteomics, we find that the presence of myelin outfoldings correlates with a loss of cytoskeletal septins in myelin. Regulated by phosphatidylinositol-(4,5)-bisphosphate (PI(4,5)P2)-levels, myelin septins (SEPT2/SEPT4/SEPT7/SEPT8) and the PI(4,5)P2-adaptor anillin form previously unrecognized filaments that extend longitudinally along myelinated axons. By confocal microscopy and immunogold-electron microscopy, these filaments are localized to the non-compacted adaxonal myelin compartment. Genetic disruption of these filaments in Sept8-mutant mice causes myelin outfoldings as a very specific neuropathology. Septin filaments thus serve an important function in scaffolding the axon/myelin-unit, evidently a late stage of myelin maturation. We propose that pathological or aging-associated diminishment of the septin/anillin-scaffold causes myelin outfoldings that impair the normal nerve conduction velocity
Preliminary assessment of the ATHENA/WFI non-X-ray background
No full textWe present a preliminary assessment of the non-X-ray background for the WFI on board ATHENA conducted at IAAT in the context of the collaborative background and radiation damage working group activities. Our main result is that in the baseline configuration originally assumed for the camera the requirement on the level of non-X-ray background could not be met. In light of the results of Geant4 simulations we propose and discuss a possible optimization of the camera design and pinpoint some open issues to be addressed in the next phase of investigation. One of these concerns the possible contribution to the non-X-ray background from soft protons and ions funneled to the focal plane through the optics. This is not quantified at this stage, here we just briefly report on our ongoing activities aimed at validating the mechanisms of proton scattering at grazing incidence
The wide field imager instrument for Athena
No full textThe "Hot and Energetic Universe" has been selected as the science theme for ESA's L2 mission, scheduled for launch in 2028. The proposed Athena X-ray observatory provides the necessary capabilities to achieve the ambitious goals of the science theme. The X-ray mirrors are based on silicon pore optics technology and will have a 12 m focal length. Two complementary camera systems are foreseen which can be moved in and out of the focal plane by an interchange mechanism. These instruments are the actively shielded micro-calorimeter spectrometer X-IFU and the Wide Field Imager (WFI).The WFI will combine an unprecedented survey power through its large field of view of 40 arcmin with a high count-rate capability (approx. 1 Crab). It permits a state-of-the-art energy resolution in the energy band of 0.1 keV to 15 keV during the entire mission lifetime (e.g. FWHM <= 150 eV at 6 keV). This performance is accomplished by a set of DEPFET active pixel sensor matrices with a pixel size matching the angular resolution of 5 arcsec (on-axis) of the mirror system. Each DEPFET pixel is a combined detector-amplifier structure with a MOSFET integrated onto a fully depleted 450 micron thick silicon bulk. The signal electrons generated by an X-ray photon are collected in a so-called internal gate below the transistor channel. The resulting change of the conductivity of the transistor channel is proportional to the number of electrons and thus a measure for the photon energy. DEPFETs have already been developed for the "Mercury Imaging X-ray Spectrometer" on-board of ESA's BepiColombo mission. For Athena we develop enhanced sensors with integrated electronic shutter and an additional analog storage area in each pixel. These features improve the peak-to-background ratio of the spectra and minimize dead time. The sensor will be read out with a new, fast, low-noise multi-channel analog signal processor with integrated sequencer and serial analog output. The architecture of sensor and readout ASIC allows readout in full frame mode and window mode as well by addressing selectively arbitrary sub-areas of the sensor allowing time resolution in the order of 10 mu s. The further detector electronics has mainly the following tasks: digitization, pre-processing and telemetry of event data as well as supply and control of the detector system. Although the sensor will already be equipped with an on-chip light blocking filter, a filter wheel is necessary to provide an additional external filter, an on-board calibration source, an open position for outgassing, and a closed position for protection of the sensor. The sensor concept provides high quantum efficiency over the entire energy band and we intend to keep the instrumental background as low as possible by designing a graded Z-shield around the sensor.All these properties make the WFI a very powerful survey instrument, significantly surpassing currently existing observatories and in addition allow high-time resolution of the brightest X-ray sources with low pile-up and high efficiency. This manuscript will summarize the current instrument concept and design, the status of the technology development, and the envisaged baseline performance
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