205 research outputs found

    Rilievi anatomo-istopatologici del carcinoma a cellule C della tiroide nell’ovino.

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    Vengono illustrati gli aspetti anatomo-istopatologici ed immunoistochimici di un carcinoma midollare della tiroide accertato in una pecora sieropositiva per Maedi/Visna virus. L' aspetto istologico, la presenza di APUD-amiloide e la positività immunoistochimica per la calcitonina depone per una diagnosi di carcinoma a cellule C

    Outbreak of avian polyomavirus with high mortality in wild Crimson's seedcrackers (Pyrenestes sanguineus)

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    Avian polyomavirus (APV) infection of recently imported Crimson’s seedcrackers (Pyrenestes sanguineus) resulted in mortality in 56 of 70 (80%) birds in January 2000. Viral infection in these birds was characterized by diarrhea, anorexia, and lethargy, and death usually ensued within 48 to 72 hr of initial clinical signs. Bacteriologic testing resulted in consistently negative results. Histologic examination of tissues from dead birds revealed large intranuclear inclusion bodies, which at electron microscopy examination, contained 42- to 49- nm viral particles. The diagnosis of APV infection was based on immunohistochemistry and immunoelectronmicroscopy, using a monoclonal antibody specific for VP-1 major capsidic APV protein. This is the first report of an acute APV outbreak in wild, recently imported, Crimson’s seedcrackers

    Thyroid C-cell carcinoma in a sheep.

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    Thyroid C-cell carcinoma in sheep is a rare tumor. In one sheep, from a group of six ewes, experimentally infected eighteen months ago with an isolate Maedi/Visna virus, medullary carcinoma was delivered in the right thyroid lobe at necropsy. Neither metastases nor other neoplastic growth were seen. Histological examens were carried out with HE, PAS-reaction and Alkaline Congo Red. The results showed a solid pattern with a connective network which apparead focally enlarged by presence of an amorphous substance. Positiveness to Congo Red staining confirmed its amyloid nature (APUD-Amyloid). Amyloid, which was not seen in previous case reported in the sheep, may be related to an abnormal production of prohormonal amino acidic sequences. Hyperplasia of C-cells was noticed in the remaining glandular tissue of both thyroid lobes. Immunohistochemical investigations were carried out with mono and polyclonal antibodies to the following antigens: calcitonin, neuron specific enolase (yy-NSE), synapthophysin, cytokeratins, neurofilaments, thyroglobulin and vimentin. The results pointed out in neoplastic and hyperplastic cells positiveness for calcitonin, NSE, synaptophysin, cytokeratins and negativeness for neurofilaments, thyroglobulin and vimentin. Synaptophysin, as delivered in previous case (Wiedemann, 1986) apparead to be a good marker for neuroendocrine tumours

    C-cell carcinoma in a sheep: histopathological and immunocytochemical study.

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    The Authors describe a case of Thyroid C-Cells Carcinoma in a sheep. The histopathological and immunocytochemical findings are reported
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