2,158 research outputs found
Theologen an Gymnasien : Vortrag bei der Wiedereröffnung des Candidaten-Convictes am Pädagogium des Klosters U. L. Fr.zu Magdeburg den 7. Mai gehalten
No full textvon C. Scheel
Effective treatment of hepatitis C-associated immune-complex nephritis with cryoprecipitate apheresis and antiviral therapy
No full textA 38-year-old pregnant woman (19th week of pregnancy) complained of fatigue, cold inducible paresthesias, generalized edema and mild arterial hypertension. Her past medical history was notable for frequent episodes of polyarthralgia and positivity for rheumatoid factor. On admission, acanthocyturia and unselective glomerular-tubular proteinuria with 19 g/d were detected with a slight decrease in creatinine clearance. Rheumatoid factor was robustly elevated and a cryocrit of 1.5 vol%, caused by a so far unknown replicative hepatitis C, was detected. Renal biopsy yielded membrano-proliferative glomerulonephritis. During pregnancy, high-dose corticosteroid therapy was administered. Edema disappeared and blood pressure normalized under albumin substitution and low-dose furosemide application. However, Cesarian section became necessary due to placental insufficiency at 27 weeks of gestation. Thereafter, neither virus load, cryocrit nor proteinuria decreased significantly under a combined therapy with pegylated interferon-a and ribavirin. Thus, cryoprecipitate apheresis was initiated resulting in robust decreases of clinical complaints, viral load, cryocrit and proteinuria. Cryoglobulinemia with renal involvement caused by hepatitis C is difficult to treat due to limitations of immunosuppressive and anti-viral therapy. In our patient, cryoprecipitate apheresis was a safe and effective therapeutic addition to standard therapy
Humorappelle: Grundlagen aus Psychologie und Gesundheitskommunikation
No full textWagner A, Sukalla F. Humorappelle: Grundlagen aus Psychologie und Gesundheitskommunikation. In: Fischer F, Pfeifer C, Scheel T, eds. Humor und Gesundheit. Hogrefe; In Press
Sonographische Darstellung von Faszikulationen und anderen Formen muskulärer Hyperkinesen
No full textMuscular hyperkinesias can be visualized by means of ultrasound (US): Ultrasonographic detection of fasciculations has been best evaluated. However, so-called ripplings, myoclonias and choreatic hyperkinesias as well as tremores can also be visualized by US. Muscular US has proven as a precise imaging technique for the detection of fasciculations. Fasciculations are brief, localized muscle twitches, usually lasting for 0.2 - 0.5 seconds. Some myoklonias may present similar in US, others present with a longer duration. In addition, muscle US allows a very easy and reliable detection of tremor frequency. This article reviews the present ultrasonographic facilities in the detection of muscular hyperkinesias and gives future perspectives
sj-pdf-1-jcb-10.1177_0271678X211064846 - Supplemental material for Resting-state functional MRI signal fluctuation amplitudes are correlated with brain amyloid-<b>β</b> deposition in patients with mild cognitive impairment
No full textSupplemental material, sj-pdf-1-jcb-10.1177_0271678X211064846 for Resting-state functional MRI signal fluctuation amplitudes are correlated with brain amyloid-β deposition in patients with mild cognitive impairment by Norman Scheel, Takashi Tarumi, Tsubasa Tomoto, C Munro Cullum, Rong Zhang and David C Zhu in Journal of Cerebral Blood Flow & Metabolism</p
Bcl-xL mediates therapeutic resistance of a mesenchymal breast cancer cell subpopulation.
No full textThe transition from an epithelial to a mesenchymal phenotype (EMT) confers increased invasiveness and clonogenic potential to tumor cells. We used a breast epithelium-derived cell culture model to evaluate the impact of EMT on the cellular sensitivity towards chemotherapeutics and apoptotic stimuli. Cells that had passed through an EMT acquired resistance towards chemotherapeutics and death ligands. Mechanistically, we found that the levels of the apoptosis inhibitor Bcl-xL were strongly enhanced in mesenchymal versus epithelial cells, whereas the pro-apoptotic proteins Bim and Puma were diminished. Clinical samples from breast cancer showed enhanced Bcl-xL staining in cells that had dispersed into the desmoplastic stroma, as compared to cells that were part of large tumor cell aggregates, suggesting increased Bcl-xL expression when cells invade the stroma. Bcl-xL was necessary for apoptotic resistance in mesenchymal cells, and its expression was sufficient to confer such resistance to epithelial cells. To antagonize Bcl-xL, BH3-mimetics were used. They successfully interfered with the proliferation and survival of mesenchymal cells, and also inhibited the growth of xenograft tumors raised from the mesenchymal subpopulation. We conclude that enhanced Bcl-xL levels confer resistance to cells upon EMT, and that Bcl-xL represents a promising target for therapy directed against invasive cancer cells
Skin-friction field in turbulent convection
No full textThe dynamics of the boundary layers of temperature and velocity are the key to deeper understanding of turbulent transport of heat and momentum in thermal convection. Here, the structure of the skin friction field at the bottom and top plates of a Rayleigh-B\'{e}nard convection setup is investigated. We therefore analyze data obtained in direct numerical simulations of Rayleigh-B\'{e}nard convection in a cylindrical cell of aspect ratio . Our analysis is focused to critical points of the two-dimensional skin friction field at the walls. We analyze the statistics of the critical points and relate them to the thermal plumes which detach from the wall and move up into bulk
Reliability exercise for the polymyalgia rheumatica classification criteria study : the Oranjewoud ultrasound substudy
No full textObjective. A study supported by the EULAR and the ACR being conducted to establish classification criteria for polymyalgia rheumatica (PMR) will include ultrasound examination of the shoulders and hips. Ultrasound (US) depicts glenohumeral joint effusion, biceps tenosynovitis, subdeltoid bursitis, hip joint synovitis, and trochanteric bursitis in PMR. These findings may aid in distinguishing PMR from other diseases. The purpose of this study was to assess standards and US interreader agreement of participants in the PMR classification criteria study. Methods. Sixteen physicians in four groups examined shoulders and hips of 4 patients and 4 healthy adults with ultrasound. Overall agreement and interobserver agreement were calculated. Results. The overall agreement (OA) between groups was 87%. The OA for healthy shoulders was 88.8%, for healthy hips 100%, for shoulders with pathology 85.2%, and 74.3% for hips with pathology, respectively. Conclusion. There was a high degree of agreement found for the examination of healthy shoulders and pathologic hips. Agreement was moderate for pathologic shoulders and perfect for healthy hips. US of shoulder and hips performed by different examiners is a reliable and feasible tool for assessment of PMR related disease pathology and can be incorporated into a classification criteria study
Interobserver reliability in muskuloskeletal ultrasonography: results from a "Teach the Teachers" rheumatologist course
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