219 research outputs found
Reconciliation of Time Perspectives as a Criterion for Therapy Completion
No full textGiancarlo Trombini, the main author of this article, has demonstrated in a series of empirical studies based on treatment examples from psychoanalytic psychotherapy that the development of relational dynamics in therapy can be assessed in an objectively verifiable way using a phenomenological criterion based on the narrative content of each session. This criterion is the comparison between the manifest dream and the subsequent associations (MDAC; Trombini, 2010, 2014, 2015).
This is a contribution to the reflexive pole of analytic psychotherapy, which is, after all, characterized by a constant oscillation between the pole of reflection and the pole of a “dreaming reception.” The present contribution continues this research with the treatment of the concluding phase of therapy, which is related to certain turning points in the processes of change in therapy (Di Chiara, 2003)
Martin Hengel, L' «ellenizzazione» della Giudea nel I secolo d. C. (coll. Studi Biblici, 104). 1993 Gunter Stemberger, Farisei, sadducei, esseni (coll. Studi Biblici, 105). 1993 Florentino García Martínez & Julio Trebolle Barrera, Gli uomini di Qumran. Letteratura, struttura sociale e concezioni religiose (coll. Studi Biblici, 113). 1996
No full textWénin André. Martin Hengel, L' «ellenizzazione» della Giudea nel I secolo d. C. (coll. Studi Biblici, 104). 1993 Gunter Stemberger, Farisei, sadducei, esseni (coll. Studi Biblici, 105). 1993 Florentino García Martínez & Julio Trebolle Barrera, Gli uomini di Qumran. Letteratura, struttura sociale e concezioni religiose (coll. Studi Biblici, 113). 1996. In: Revue théologique de Louvain, 28ᵉ année, fasc. 4, 1997. p. 534
Martin Hengel, L' «ellenizzazione» della Giudea nel I secolo d. C. (coll. Studi Biblici, 104). 1993 Gunter Stemberger, Farisei, sadducei, esseni (coll. Studi Biblici, 105). 1993 Florentino García Martínez & Julio Trebolle Barrera, Gli uomini di Qumran. Letteratura, struttura sociale e concezioni religiose (coll. Studi Biblici, 113). 1996
No full textWénin André. Martin Hengel, L' «ellenizzazione» della Giudea nel I secolo d. C. (coll. Studi Biblici, 104). 1993 Gunter Stemberger, Farisei, sadducei, esseni (coll. Studi Biblici, 105). 1993 Florentino García Martínez & Julio Trebolle Barrera, Gli uomini di Qumran. Letteratura, struttura sociale e concezioni religiose (coll. Studi Biblici, 113). 1996. In: Revue théologique de Louvain, 28ᵉ année, fasc. 4, 1997. p. 534
Impact of Adopting Population Pharmacokinetics for Tailoring Prophylaxis in Haemophilia A Patients: A Historically Controlled Observational Study
No full textBackground Performing individual pharmacokinetics (PK) studies in clinical practice can be simplified by adopting population PK-based profiling on limited post-infusion samples. The objective of this study was to assess the impact of population PK in tailoring prophylaxis in patients with haemophilia A. Patients and Methods Individual weekly treatment plans were developed considering predicted plasma factor activity levels and patients' lifestyle. Patients were trained using a visual traffic-light scheme to help modulate their level of physical activity with respect to factor infusions timing. Annualized joint bleeding rate (ABJR), haemophilia-specific quality of life questionnaire for adults (Haemo-QoL-A) and factor utilization were measured for 12 months before and after tailoring, compared within patients and analysed separately for those previously on prophylaxis (P), situational prophylaxis (SP) or on-demand (OD). Results Sixteen patients previously on P, 10 on SP and 10 on OD were enrolled in the study. The median (lower, upper quartile) ABJR changed from 2.0 (0, 4.0) to 0 (0, 1.6) for P (p = 0.003), from 2.0 (2.0, 13.6) to 3.0 (1.4, 7.2) for SP (p = 0.183) and from 16.0 (13.0, 25.0) to 2.3 (0, 5.0) for OD (p = 0.003). The Haemo-QoL-A total score improved for 58% of P, 50% of SP and 29% of OD patients. Factor utilization (IU/kg/patient/year) increased by 2,400 (121; 2,586) for P, 1,052 (308; 1,578) for SP and 2,086 (1,498; 2,576) for OD. One of 138 measurements demonstrated a factor activity level below the critical threshold of 0.03 IU/mL while the predicted level was above the threshold. Conclusion Implementing tailored prophylaxis using a Bayesian forecasting approach in a routine clinical practice setting may improve haemophilia clinical outcomes
Origin of CD8<sup>+</sup> effector and memory T cell subsets.
No full textDifferentiation of CD8 T cells into diverse effector- and memory populations is an important feature of these cells and necessary for the development of protective immunity against pathogens and certain tumors. In this work we analyzed the differentiation of naïve antigen-specific CD8 T cells after adoptive transfer of single cells into wildtype mice. With the help of this novel tool we could show that after activation, a single CD8 T cell harbors the potential to differentiate into all major subsets. Interestingly, we found in addition that the differentiation patterns of transferred and polyclonal endogenous T cells was almost identical in individual mice. This implicates that factors operative during the expansion phase play an important role in the development and shaping of CD8 T cell responses. These results are important for the development of more effective T cell-based vaccines and for adoptive immunotherapy
Multisystem inflammatory syndrome in children (MIS-C)
No full textMultisistemski upalni sindrom u djece povezan s COVID-19 je relativno novi klinički sindrom sličan Kawasakijevoj bolesti koji se javlja oko 2–6 tjedana nakon preboljele SARS-CoV-2 infekcije. Bolest karakterizira vrućica uz zahvaćanje više organa i organskih sustava (koža/sluznice, gastrointestinalni, kardiovaskularni...), a u laboratorijskim nalazima dominiraju povišeni upalni parametri. Nema specifičnog dijagnostičkog testa za potvrdu ove bolesti, već je to dijagnoza isključenja, a postavlja na temelju dijagnostičkih kriterija. Osnovu liječenja čini primjena intravenskih imunoglobulina i kortikosteroida uz simptomatske i suportivne mjere. Bolest je karakterizirana sklonošću izazivanja kardioloških komplikacija zbog čega je važno sustavno praćenje ovih bolesnika i nakon akutne bolesti.Multisystemic inflammatory syndrome in children associated with COVID-19 is a relatively new clinical syndrome similar to Kawasaki disease that occurs about 2–6 weeks after SARS-CoV-2 infection. The disease is characterized by fever and involvement of several organ systems (skin/mucous membranes, gastrointestinal, cardiovascular...) associated with elevated inflammatory parameters. There is no specific diagnostic test to confirm this disease, it is a diagnosis of exclusion, based on specific diagnostic criteria. The basis of treatment is the use of intravenous immunoglobulins and corticosteroids with symptomatic and supportive measures. The disease is characterized by tendency to cause cardiac complications, which is why it is important to systematically monitor these patients even after acute illness
NKG2D-independent suppression of T cell proliferation by H60 and MICA
No full textThe activating receptor NKG2D recognizes a wide range of different ligands, some of which are primarily expressed in "stressed" tissues or on tumor cells. Until now, similar stimulatory effects on natural killer and CD8+ T cells have been described for all NKG2D ligands, and the NKG2D receptor/ligand system has therefore been interpreted as a sensor system involved in tumor immune surveillance and activation of immune responses. We show here that the NKG2D ligands H60 and MIC class 1 chain-related protein A (MICA) can also mediate strong suppressive effects on T cell proliferation. Responsiveness to H60- and MICA-mediated suppression requires IL-10 and involves a receptor other than NKG2D. These findings might provide explanations for the observation that strong in vivo NKG2D ligand expression, such as that on tumor cells, sometimes fails to support effective immune responses and links this observation to a distinct subgroup of NKG2D ligands
Preliminary steps in co-design for climate change adaptation and mitigation tools in the tourism sector: a case study in the NEVERMORE project
No full textMountains are considered a hotspot of climate change due to a more pronounced increase of average temperature vs. the global average, almost twice compared (Adler et al.,2022; APPA,2022a). The Autonomous Province of Trento in Trentino (Italy) is currently developing its Strategy for Mitigation and Adaptation to climate change. It is also a partner of the NEVERMORE project consortium (Horizon EU 2022-2026, GA No101056858S) and its territory is one of its five Case Studies in Europe. NEVERMORE overall consists of 16 organizations engaged to support excellence for research on climate science and climate policy. The project focuses on modelling theory, to overcome the common silo approach and to support the development of an integrated assessment, one for the analysis of impacts, risks and interactions of climate change in diverse sectors and adaptation/mitigation strategies. Trentino represents one of the Case Study regions - with the Municipality of Sitia (EL), the County of Norrbotten (SE), the Region of Murcia (ES) and the Danube Delta (RO) - that will help deliver and localize the project and its solutions to better understand and tackle climate change as to promote awareness among local stakeholders and communities. In Trentino, the chosen focus is on tourism and its interlinked sectors as water and energy management and biodiversity.
Tourism in Trentino (population 540.958) is one of the economic sectors with great impact on the economy and wellbeing, contributing to 7% of provincial GDP (estimated 1,505.5 mln€) a figure that does not consider the impact of investments, daily trippers and other indirect revenues. It is also a sector that features over 1,400 hotel facilities (90,500 bed places) while if considering rentals of private accommodation/second homes these figures increase to 73,400 (480,000 bed places). In 2019, Trentino recorded over 4.5 million arrivals and more than 18.4 million tourism nights, a figure that rises to 6 million arrivals and 32.8 tourism nights considering tourists in second homes, a ratio of 60:1 compared to inhabitants (ISPAT). Tourism is a field strictly interdependent with other key economic sectors in the region such as trade, agriculture, ecosystem services, and particularly the energy sector. For Trentino’s Case Study there are several observed effects of climate change which are the baseline of the current project activities and were reported also by the provincial Position Report on Climate Change (APPA,2022a): a) rising temperatures, marked especially in locations at valley floors (e.g. the estimated temperature increase for Trento is about 2°C compared to the period 1850-1899 and over the last 40 years the variation in average monthly temperatures has been characterized by significant increasing trends, with an average value between 0.03 and 0.05°C year-1 b) a significant reduction in both average seasonal snow depth and duration of snow cover c) the depletion of permafrost and the retreat in glaciers and d) increases in urban heat waves and extreme events. Some other challenges were identified as particularly relevant for the case study’s focus, due to the electricity and water demand in the tourism sector and ski resorts, linked to resource needs for artificial snowmaking, affecting energy and water use (Viesi et.al, 2023; Polderman et al.2020). Consequently, climate change is impacting directly and indirectly the tourism economy with variations on tourism seasons due to shifts of the seasonal snow-cover dynamic, or influence the state of natural capital, safety and wellness and health of local communities. There are also challenges given by competition over resources in various sectors, particularly water (APPA,2022b), by over-tourism in some sites and in some periods and a lack in data availability for data-driven decision making.
Within next years’ activities, NEVERMORE aims to develop new models and interactive digital tools for policymakers and citizens, to figure future scenarios and support the creation of more effective adaptation and mitigation policies. One of the pillars of the project, particularly on the local scale, is to ensure the active participation of public and private stakeholders in collaborative activities of co-design, co-creation and co-assessment for models and solutions. The project sets-up a dynamic stakeholder engagement strategy to involve key actors within Local Councils of Stakeholders built from the first project semester in each Case Study region. The approach follows a particular engagement strategy that will help both partners in giving information and receiving feedback from the territory and key stakeholders in being proactive players in understanding how to tackle climate change challenges in their territories. Stakeholders shall support the identification of local challenges and priorities, imagine future scenarios, recommend possible measures and provide inputs for the models and insights for the design of digital tools: a web interface for climate change scenarios, an interactive policy catalogue and a gamification tool to raise awareness on climate change issues.
In Trentino, the Local Council was built to foster the encounter and discussion among local key players that represent the tourism sector's needs from various points of view. Stakeholders (between 15 to 30) from diverse fields - representatives of academia, policymakers, natural parks, tourism consortia, media, mountain huts, alpine guides, ski instructors, private businesses as the civil society - meet three times a year. Here, as well as in other Case Studies, collaborative events have already taken place using co-design and co-creation methods to foster collaborative and result-oriented discussion. A first consultation (March 2023) was organized with the goal of understanding and collecting stakeholders’ perceptions on the challenges posed by climate change and for them to initially suggest how their diverse roles could help meet these challenges. Results from collaborative discussions highlight needs for: a) a cultural change and the creation of awareness, b) a change towards more balanced tourist flows, c) the usage optimization of important resources such as water and energy, d) integrated and dynamic policies. A second consultation (May 2023) was organized to examine several measures of both mitigation and adaptation amidst the more connected and exemplifying measures collected in NEVERMORE research activities and in the local policy framework. Selected measures were clustered among the topics of a balanced touristic flow management, integrated management for water, decarbonization and energy efficiency, corporate sustainability, human capital and sustainable mobility. Participants explored awareness, gaps, effectiveness of these measures and reasoned also on the trade-offs or synergies that different measures trigger. The discussion helped acquire more knowledge on bottom-up experiences and on some new active measures. Results have shown awareness, although not in the very detail, on the diverse measures in place for the topics and several responses from territories. An initial identification of gaps has been collected for all topics which will help focus further works of the Local Council and Case Study.
Further steps will deal with the local issues of risks, problems and needs, on elements of vulnerability, on future scenarios and their benefits and trade-offs with support of a risk assessment methodology. Next collaborative events are planned in Autumn 2023 and in the following years up to 2026; with a process that will help engage stakeholders in providing important feedback and involve them in project outcomes. This collaborative approach, thus, is fostering a co-creation process that will put focus on local knowledge and information on climate change and will be shared between technical partners of the NEVERMORE consortium, policymakers and other relevant private and public stakeholders
Working Together, Working Against Each Other, And Working Past Each Other In Therapy And Supervision. A Gestalt Psychological View On Structure And Dynamics Of The Therapeutic Relationship
No full textCrises in therapist-patient relationship can also become a challenge in clinical supervision. However, success and failure in establishing and maintaining constructive relationships in therapy and supervision is not only subject to a lucky fit of personal characteristics (therapist A gets along well/badly with client B; supervisee A gets along well/badly with supervisor C). Rather, we can identify determining field conditions in the overall therapeutic and supervisory situation for this outcome. We do not only focus on the persons involved, but also on their environment, the task to be accomplished together, further framework conditions and the power relations resulting from their mutual influence-in the supervised case of therapy as well as in supervision itself. We want to examine the structure and dynamics of these relationships from a genuine Gestalt psychological perspective. What contributes to a cooperative atmosphere? When do goals get out of sight? What can make the atmosphere hostile? How do such developments become accessible in supervision
<i>Notholca laurentiae</i> and <i>N</i>. <i>michiganensis</i>, New Rotifers from the Laurentian Great Lakes Region
No full text The descriptions of two new planktonic rotifers, both cold stenotherms, is presented. Notholca laurentiae n.sp. is a predominant winter rotifer of the Laurentian Great Lakes, but to date has not been found in inland lakes of the region. Morphologically its closest relative is the European brackish water species, N. salina Focke.Notholca michiganensis n.sp. has been recorded only in the oligotrophic inland lakes of the northern portion of Michigan’s lower peninsula during winter and early spring (water temperatures 0.5–5.2 C). Morphologically, N. michiganensis is similar to, but distinctly smaller than N. frigida Jaschnov. </jats:p
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