99 research outputs found
Personal branding in female entrepreneurship: Exploring narrative devices in the sustainable fashion industry
No full text
The role of the central limit theorem in the heterogeneous ensemble of Brownian particles approach
No full textThe central limit theorem (CLT) and its generalization to stable distributions have been widely described in literature. However, many variations of the theorem have been defined and often their applicability in practical situations is not straightforward. In particular, the applicability of the CLT is essential for a derivation of heterogeneous ensemble of Brownian particles (HEBP). Here, we analyze the role of the CLT within the HEBP approach in more detail and derive the conditions under which the existing theorems are valid
Synthetic Thyroid Hormone Receptor-β Agonists Promote Oligodendrocyte Precursor Cell Differentiation in the Presence of Inflammatory Challenges
No full textOligodendrocytes and their precursors are the cells responsible for developmental myelination and myelin repair during adulthood. Their differentiation and maturation processes are regulated by a complex molecular machinery driven mainly by triiodothyronine (T3), the genomic active form of thyroid hormone, which binds to thyroid hormone receptors (TRs), regulating the expression of target genes. Different molecular tools have been developed to mimic T3 action in an attempt to overcome the myelin repair deficit that underlies various central nervous system pathologies. In this study, we used a well-established in vitro model of neural stem cell-derived oligodendrocyte precursor cells (OPCs) to test the effects of two compounds: the TRβ1 ligand IS25 and its pro-drug TG68. We showed that treatment with TG68 induces OPC differentiation/maturation as well as both the natural ligand and the best-known TRβ1 synthetic ligand, GC-1. We then described that, unlike T3, TG68 can fully overcome the cytokine-mediated oligodendrocyte differentiation block. In conclusion, we showed the ability of a new synthetic compound to stimulate OPC differentiation and overcome inflammation-mediated pathological conditions. Further studies will clarify whether the compound acts as a pro-drug to produce the TRβ1 ligand IS25 or if its action is mediated by secondary mechanisms such as AMPK activation
Table S6 -Supplemental material for The Local Impacts of World Bank Development Projects Near Sites of Conservation Significance
No full textSupplemental material, Table S6 for The Local Impacts of World Bank Development Projects Near Sites of Conservation Significance by Graeme M. Buchanan, Bradley C. Parks, Paul F. Donald, Brian F. O’Donnell, Daniel Runfola, John P. Swaddle, Łukasz Tracewski and Stuart H. M. Butchart in The Journal of Environment & Development</p
Table S5 -Supplemental material for The Local Impacts of World Bank Development Projects Near Sites of Conservation Significance
No full textSupplemental material, Table S5 for The Local Impacts of World Bank Development Projects Near Sites of Conservation Significance by Graeme M. Buchanan, Bradley C. Parks, Paul F. Donald, Brian F. O’Donnell, Daniel Runfola, John P. Swaddle, Łukasz Tracewski and Stuart H. M. Butchart in The Journal of Environment & Development</p
Appendix A - Supplemental material for The Local Impacts of World Bank Development Projects Near Sites of Conservation Significance
No full textSupplemental material, Appendix A for The Local Impacts of World Bank Development Projects Near Sites of Conservation Significance by Graeme M. Buchanan, Bradley C. Parks, Paul F. Donald, Brian F. O’Donnell, Daniel Runfola, John P. Swaddle, Łukasz Tracewski and Stuart H. M. Butchart in The Journal of Environment & Development</p
Personal branding in female entrepreneurship: Exploring narrative devices in the sustainable fashion industry
No full textSupplemental material for The Local Impacts of World Bank Development Projects Near Sites of Conservation Significance
No full textSupplemental material for The Local Impacts of World Bank Development Projects Near Sites of Conservation Significance by Graeme M. Buchanan, Bradley C. Parks, Paul F. Donald, Brian F. O’Donnell, Daniel Runfola, John P. Swaddle, Łukasz Tracewski and Stuart H. M. Butchart in The Journal of Environment & Development</p
Impact of PPAR-alpha polymorphisms-The case of metabolic disorders and atherosclerosis
No full textPeroxisome proliferator activated receptor α (PPARα) has the most relevant biological functions among PPARs. Activation by drugs and dietary components lead to major metabolic changes, from reduced triglyceridemia to improvement in the metabolic syndrome. Polymorphisms of PPARα are of interest in order to improve our understanding of metabolic disorders associated with a raised or reduced risk of diseases. PPARα polymorphisms are mainly characterized by two sequence changes, L162V and V227A, with the latter occurring only in Eastern nations, and by numerous SNPs (Single nucleotide polymorphisms) with a less clear biological role. The minor allele of L162V associates with raised total cholesterol, LDL-C (low-density lipoprotein cholesterol), and triglycerides, reduced HDL-C (high-density lipoprotein metabolism), and elevated lipoprotein (a). An increased cardiovascular risk is not clear, whereas a raised risk of diabetes or of liver steatosis are not well supported. The minor allele of the V227A polymorphism is instead linked to a reduction of steatosis and raised γ-glutamyltranspeptidase levels in non-drinking Orientals, the latter being reduced in drinkers. Lastly, the minor allele of rs4353747 is associated with a raised high-altitude appetite loss. These and other associations indicate the predictive potential of PPARα polymorphisms for an improved understanding of human disease, which also explain variability in the clinical response to specific drug treatments or dietary approaches
- …
