175 research outputs found
Axinelline A e B: due ciclopeptidi con attività antiproliferativa dalla spugna Axinella carteri.
No full textNew jaspamide derivatives from the marine sponge Jaspis splendans collected in Vanuatu
No full textTwo new jaspamide derivs., jaspamide B (I) and jaspamide C (II), along with jaspamide have been isolated from the
marine sponge Jaspis splendans collected in Vanuatu. Their chem. structures were detd. from 1- and 2-dimensional
NMR studies and mass spectral data. I and II inhibited the in vitro growth of the NSCLC-N6 human tumor cell lines with
IC50 values in the mg/mL range
Callipeltins B and C; bioactive peptides from a marine Lithistida sponge Callipelta sp
No full textFollowing the characterization of callipeltin A (I) two new cytotoxic peptides, callipeltin A (II) and C (III), were isolated
from the New Caledonian sponge Callipelta sp. Callipeltin B possess the same cyclic depsipeptidal structure as in
callipeltin A and differs from I by having the N-terminal 2,3-dimethylpyroglutamic acid unit instead of the tripeptide chain
with the N-terminus blocked by an hydroxyacid. Callipeltin C is simply the acyclic callipeltin A. The structures II-III
have been detd. by NMR expts., FAB mass spectrometry, evaluation of the amino acids obtained by acid hydrolysis and
by comparison of the data with those of callipeltin A
Callipeltoside A: a cytotoxic aminodeoxy sugar-containing macrolide of a new type from the marine lithistidasponge Callipelta sp
No full textA cytotoxic glycoside macrolide, callipeltoside A (I), has been isolated from the marine lithistid sponge Callipelta sp.,
collected off New Caledonia. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The
complete relative stereochem. is proposed from the anal. of ROESY and NOE difference expts. Callipeltoside A
represents the first member of a new class of marine-derived macrolides, contg. unusual structural features including a 4-
amino-4,6-dideoxy-2-O,3-C-dimethyl-a-talopyranosyl-3,4-urethane unit
Crellastatin A: a cytotoxic bis-steroid sulfate from the Vanuatu marine sponge Crella sp
No full textA new nonsym. dimeric steroid, crellastatin A (I), was isolated from the Vanuatu Island marine sponge Crella sp.
Structural assignment was accomplished through extensive 2D NMR spectroscopy. The stereochem. of I was
established from an anal. of ROESY expts. and from mol. mechanics and dynamics calcns. I, which possesses an
unprecedented connection through the side chains, exhibits in vitro cytotoxic activity against NSCLC-N6 cells (IC50 of
1.5 mg/mL)
Isolation and structural elucidation of the crellastatins I-M: cytotoxic bissteroid derivatives from the vanuatu marine sponge Crella sp
No full textContinued investigation of cytotoxic exts. of the marine sponge Crella sp. has resulted in the discovery of crellastatins I-M (e.g. I, crellastatin I). Their structures were detd. by interpretation of their NMR spectroscopic and FABMS data. These new bis-steroid derivs. exhibited cytotoxic activity against NSCLC cell lines with IC50 values in the range of 1-8 .mu.g/m
Crellastatin A : a Cytotoxic Bis-Steroid Sulfate from the Vanuatu Marine Sponge Crella sp.
No full textA new nonsymmetric dimeric steroid, crellastatin A (1), was isolated from the Vanuatu Island marine sponge Crella sp. Structural assignment was accomplished through extensive 2D NMR spectroscopy. The stereochemistry of 1 was established from an analysis of ROESY experiments and from molecular mechanics and dynamics calculations. Crellastatin A (1), which possesses an unprecedented connection through the side chains, exhibits in vitro cytotoxic activity against NSCLC-N6 cells (IC(50) of 1.5 &mgr;g/mL)
Crellastatins: a new class of cytotoxic dimeric sulphated sterols from the Vanuatu sponge Crella sp.
No full textIsolation and structural elucidation of crellastatins B-H. Cytotoxic bis(steroid) derivatives from the Vanuatumarine sponge Crella
No full textSeven new cytotoxic dimeric steroids, crellastatins B-H, were isolated from the Vanuatu sponge Crella sp. They were
structurally characterized on the basis of 2D-NMR (500 MHz) and FAB-MS data. All the new compds. show the same
unprecedented junction between the monomeric units, formed via their side-chains, whereas they differ from crellastatin
A in the hydroxylation pattern of the 2 tetracyclic cores. Like crellastatin A , crellastatins B-H exhibit in vitro antitumor
activity against human bronchopulmonary non-small-cell lung carcinoma cell lines (NSCLC) with IC50 values in the range
of 2-10 mg/mL
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