1,929 research outputs found
Congratulations to Dr. Pennell
No full textDr. Timothy C. Pennell graduated from Bowman Gray School of Medicine in 1960 and joined the medical school faculty in 1966. In this 1992 photo he was honored for the third time in his career by having the school's yearbook, The Gray Matter, dedicated to him. Dr. Pennell at the time was chief of professional services for North Carolina Baptist Hospital and was director of Bowman Gray's Office of International Health Affairs since its inception in 1984. He was very instrumental in developing academic affiliations between Bowman Gray and medical schools in Japan, China, Italy and Norway. Dr. Pennell was also active with medical professionals in Africa, Asia and South America.Published in: Medical Alumni News
Pennell, Benjamin C.
No full textCarte de Visite of Captain Benjamin C. Pennell, 17th Maine Infantry, Company B; From the MacDonald Collectionhttps://digitalmaine.com/arc_civilwarportraits/2593/thumbnail.jp
Pennell, Benjamin C.
No full textCarte de Visite of Captain Benjamin C. Pennell, Company B, 17th Maine Infantry; From the Maine State Archives Collectionhttps://digitalmaine.com/arc_civilwarportraits/1460/thumbnail.jp
Pennell, Benjamin C.
No full textCarte de Visite of Captain Benjamin C. Pennell, 17th Maine Infantry, Company B; From the MacDonald Collectionhttps://digitalmaine.com/arc_civilwarportraits/2593/thumbnail.jp
Pennell, Benjamin C.
No full textCarte de Visite of Captain Benjamin C. Pennell, Company B, 17th Maine Infantry; From the Maine State Archives Collectionhttps://digitalmaine.com/arc_civilwarportraits/1460/thumbnail.jp
Multi-center transferability of a breath-hold T2 technique for myocardial iron assessment.
No full textBackground: Cardiac iron overload is the leading cause of death in thalassemia major and is usually assessed using myocardial T2* measurements. Recently a cardiovascular magnetic resonance (CMR) breath-hold T2 sequence has been developed as a possible alternative. This cardiac T2 technique has good interstudy reproducibility, but its transferability to different centres has not yet been investigated.
Methods and Results: The breath-hold black blood spin echo T2 sequence was installed and validated on 1.5T Siemens MR scanners at 4 different centres across the world. Using this
sequence, 5–10 thalassemia patients from each centre were scanned twice locally within a week for local interstudy reproducibility (n = 34) and all were rescanned within one month at the standardization centre in London (intersite reproducibility). The local interstudy reproducibility
(coefficient of variance) and mean difference were 4.4% and -0.06 ms. The intersite reproducibility and mean difference between scanners were 5.2% and -0.07 ms.
Conclusion: The breath-hold myocardial T2 technique is transferable between Siemens scanners with good intersite and local interstudy reproducibility. This technique may have value in the diagnosis and management of patients with iron overload conditions such as thalassemia
hirtella
No full textAsclepias hirtella (Pennell) Woodsontall green milkweed;green milkweed;stiff-haired milkweed;prairie milkweedasclépiade hérisséeAsclepias hirtellaalong U.S. #71, about 2 miles north of Butleropen fiel
Value of black blood T2*cardiovascular magnetic resonance.
No full textPurpose
To assess whether black blood T2* cardiovascular magnetic resonance is superior to conventional white blood imaging of cardiac iron in patients with thalassaemia major (TM).
Materials and methods
We performed both conventional white blood and black blood T2* CMR sequences in 100 TM patients to determine intra and inter-observer variability and presence of artefacts. In 23 patients, 2 separate studies of both techniques were performed to assess interstudy reproducibility.
Results
Cardiac T2* values ranged from 4.5 to 43.8 ms. The mean T2* values were not different between black blood and white blood acquisitions (20.5 vs 21.6 ms, p = 0.26). Compared with the conventional white blood diastolic acquisition, the coefficient of variance of the black blood CMR technique was superior for intra-observer reproducibility (1.47% vs 4.23%, p < 0.001), inter-observer reproducibility (2.54% vs 4.50%, p < 0.001) and inter-study reproducibility (4.07% vs 8.42%, p = 0.001). Assessment of artefacts showed a superior score for black blood vs white blood scans (4.57 vs 4.25; p < 0.001).
Conclusions
Black blood T2* CMR has superior reproducibility and reduced imaging artefacts for the assessment of cardiac iron, in comparison with the conventional white blood technique, which make it the preferred technique for clinical practice
Right ventricular volumes and function in thalassemia major patients in the absence of myocardial iron overload
No full textAim: We aimed to define reference ranges for right ventricular (RV) volumes, ejection fraction (EF) in thalassemia major patients (TM) without myocardial iron overload.Methods and results: RV volumes, EF and mass were measured in 80 TM patients who had no myocardial iron overload (myocardial T2* > 20 ms by cardiovascular magnetic resonance). All patients were receiving deferoxamine chelation and none had evidence of pulmonary hypertension or other cardiovascular comorbidity. Forty age and sex matched healthy non-anemic volunteers acted as controls. The mean RV EF was higher in TM patients than controls (males 66.2 +/- 4.1% vs 61.6 +/- 6%, p = 0.0009; females 66.3 +/- 5.1% vs 62.6 +/- 6.4%, p = 0.017), which yielded a raised lower threshold of normality for RV EF in TM patients (males 58.0% vs 50.0% and females 56.4% vs 50.1%). RV end-diastolic volume index was higher in male TM patients (mean 98.1 +/- 17.3 mL vs 88.4 +/- 11.2 mL/m(2), p = 0.027), with a higher upper limit (132 vs 110 mL/m(2)) but this difference was of borderline significance for females (mean 86.5 +/- 13.6 mL vs 80.3 +/- 12.8 mL/m(2), p = 0.09, with upper limit of 113 vs 105 mL/m(2)). The cardiac index was raised in TM patients (males 4.8 +/- 1.0 L/min vs 3.4 +/- 0.7 L/min, p < 0.0001; females 4.5 +/- 0.8 L/min vs 3.2 +/- 0.8 L/min, p < 0.0001). No differences in RV mass index were identified.Conclusion: The normal ranges for functional RV parameters in TM patients with no evidence of myocardial iron overload differ from healthy non-anemic controls. The new reference RV ranges are important for determining the functional effects of myocardial iron overload in TM patients
Introduction to A World at War, 1911-1949: Explorations in the Cultural History of War
No full textThis is the author accepted manuscript. The final version is available
from Brill via the DOI in this record
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