1,099 research outputs found
The Folio: F. C. C. Magazine
No full textEditorial. pp. 1-2; Samuel, V. M.-Essay-Pilgrimage to Lincoln's Tomb. pp. 2-7; Burke, D. C.-Article-Self-Importance. pp. 7-10; Chaubey, S. K.-Article-The Artist's Cry. pp. 10-11; The Co-Eds' Corner. pp. 11-12; Ranjit Kumar-Whiffs of Wisdom. pp. 12-13; Goverdhan Das-Poetry-Moments of Tryst. pp. 13; Kak, B. N.-Tourism-Kashmir. pp. 13-15; Satyindra Singh-News and Notes. pp. 16-18; W. P. B. pp. 19-20; News from the Outposts. pp. 20-21; The Alumni Corner. pp. 21-22; In Memoriam. pp. 23-24; [Hindi]. 12 p.; Punjabi Kiyari [Punjabi]. 4 p.; The Folio [Urdu]. 16 p.S. Bhagat Singh Malhotra, K. B. S. Maqbool Shah. after page 20; M. K. Tandon, Masud H. Sayid, Philipose Mathai. after page 22; M. L. Banerji, Rev Canon A. B. Chandu Lal, Rev J. Ali Baksh, Mangat Rai, Malik Mohd. Shafi. after page 2
The Folio: F. C. C. Magazine
No full textMaqbool Ahmad Bhatty-Editorial. pp. 1-2; Om Prakash Bhagat-I Remember You. pp. 2; AShiv Kumar Lal-Poetry-A Bit of Clay. pp. 2; Manmohan Nath-Article-The Late H. G. Wells. pp. 2-4; Poetry-A Reverie. pp. 4; Gilani, S. A. S.-Story-The Haunted Valley. pp. 5-6; Virendar Laroia-Poetry-Grave Humour. pp. 6; Ayoob Ali-Article-Religion in Life. pp. 7-8; Bates, Marquis A.-Story-Palmists and Palmistry. pp. 8-10; Jaipal Nangia-Poetry-The Riddle of the Fluttering Leaves. pp. 11; Saran Singh-Story-A Return Journey. pp. 11-12; Baljit Singh-Travelogues-A Trip to Jogindarnagar. pp. 13-14; Obituary Notices. pp. 15; [Hindi]. 8 p.; The Folio [Urdu]. 6 p.The Late Professor S. M. Paul. after page 1
myExperiment: Defining the Social Virtual Research Environment
No full textThe myExperiment Virtual Research Environment supports the sharing of research objects used by scientists, such as scientific workflows. For researchers it is both a social infrastructure that encourages sharing and a platform for conducting research, through familiar user interfaces. For developers it provides an open, extensible and participative environment. We describe the design, implementation and deployment of myExperiment and suggest that its four capabilities - research objects, social model, open environment and actioning research - are necessary characteristics of an effective Virtual Research Environment for e-research and open science
The myExperiment Open Repository for Scientific Workflows
No full textmyExperiment is an open repository solution for the born-digital items arising in contemporary research practice, in particular scientific workflows and experiment plans. Launched in November 2007, the public repository (myexperiment.org) has established a significant collection of scientific workflows, spanning multiple disciplines and multiple workflow systems, which has been accessed by over 16,000 users worldwide. Built according to Web 2.0 design principles, myExperiment demonstrates the success of blending modern social curation methods with the demands of researchers sharing hard-won intellectual assets and research works within a scholarly communication lifecycle. myExperiment is an important component in the revolution in creating, sharing and publishing scientific results, and has already established itself as a valuable and unique repository with a growing international presence
Author collaboration for AI and sustainable agriculture research work.
No full textAuthor collaboration for AI and sustainable agriculture research work.</p
Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability
No full textBackground - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated. We therefore investigated the direct effect of CRP on vascular reactivity. Methods and Results - The effects of isolated, pure human CRP on vasoreactivity and protein expression were studied in vascular rings and cells in vitro, and effects on blood pressure were studied in rats in vivo. The temporal relationship between changes in CRP concentration and brachial flow-mediated dilation was also studied in humans after vaccination with Salmonella typhi capsular polysaccharide, a model of inflammatory endothelial dysfunction. In contrast to some previous reports, highly purified and well-characterized human CRP specifically induced hyporeactivity to phenylephrine in rings of human internal mammary artery and rat aorta that was mediated through physiological antagonism by nitric oxide (NO). CRP did not alter endothelial NO synthase protein expression but increased protein expression of GTP cyclohydrolase-1, the rate-limiting enzyme in the synthesis of tetrahydrobiopterin, the NO synthase cofactor. In the vaccine model of inflammatory endothelial dysfunction in humans, increased CRP concentration coincided with the resolution rather than the development of endothelial dysfunction, consistent with the vitro findings; however, administration of human CRP to rats had no effect on blood pressure. Conclusions - Pure human CRP has specific, direct effects on vascular function in vitro via increased NO production; however, further clarification of the effect, if any, of CRP on vascular reactivity in humans in vivo will require clinical studies using specific inhibitors of CRP. © 2005 American Heart Association, Inc
Towards Open Science: The myExperiment approach
No full textBy making research content more reusable, and providing a social infrastructure which facilitates sharing, the human aspects of the scholarly knowledge cycle may be accelerated and ‘time-to-discovery’ reduced. We propose that the key to this is the sharing of methods and processes. We present myExperiment, a social web site for discovering, sharing and curating Scientific Workflows and experiment plans, and describe how myExperiment facilitates the management and sharing of research workflows, supports a social model for content curation tailored to the researcher and community, and supports Open Science by exposing content and functionality to the users’ tools and applications. Based on this we introduce the notion of the Research Object – the work objects that are built, transformed and published in the course of scientific experiments – and suggest that by encapsulating methods with results we can achieve research that is more reusable and repeatable and hence rapid and robust
BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma
No full textThe BCL6 proto-oncogene encodes a transcriptional repressor that is required for germinal center (GC) formation and whose deregulation by genomic lesions is implicated in the pathogenesis of GC-derived diffuse large B cell lymphoma (DLBCL) and, less frequently, follicular lymphoma (FL). The biological function of BCL6 is only partially understood because no more than a few genes have been functionally characterized as direct targets of BCL6 transrepression activity. Here we report that the anti-apoptotic proto-oncogene BCL2 is a direct target of BCL6 in GC B cells. BCL6 binds to the BCL2 promoter region by interacting with the transcriptional activator Miz1 and suppresses Miz1-induced activation of BCL2 expression. BCL6-mediated suppression of BCL2 is lost in FL and DLBCL, where the 2 proteins are pathologically coexpressed, because of BCL2 chromosomal translocations and other mechanisms, including Miz1 deregulation and somatic mutations in the BCL2 promoter region. These results identify an important function for BCL6 in facilitating apoptosis of GC B cells via suppression of BCL2, and suggest that blocking this pathway is critical for lymphomagenesis
Interferon signalling in the liver : implications for the natural course and therapy of hepatitis C
No full textHepatitis C virus is a global health concern, estimated to infect 2-3% of the world's population. Inter-individual differences in the course of infection and response to therapy, highlighted by recent genomewide association studies, point to the crucial role of the host immune system in the efficient control of infection. Ongoing progress in the studies of the role of innate immunity during hepatitis C virus infection has improved our understanding of the intricacies of the host-virus interactions. In this work I present and discuss results of three studies aimed to dissect interferon signalling in the liver in the context of natural course or therapy of hepatitis C virus infection.
Interferon-based therapies are in clinical use for treatment of diseases such as hepatitis C virus infection or multiple sclerosis. Interferon-induced regulators of the Jak-STAT signalling are known to involve in negative feedback loops and affect the response to exogenously administered interferon alpha. In this context it is important to understand which interferon subtypes are potent inducers of the negative regulators and whether all interferons are equally sensitive to the inhibitory mechanisms. To tackle this question we attempted to characterize and compare response patterns to interferons alpha, beta and lambda in a setting of continuous and repeated stimulation (see Section 3.1).
The acute phase of hepatitis C virus infection in humans (first 6 months after transmission) is characterized by high rates of spontaneous clearance and excellent treatment response (>90% cure rate). As the infection at that stage is mostly asymptomatic, it is rarely diagnosed and, in comparison to the chronic phase of hepatitis C virus infection, little is known about the human liver response to acute hepatitis C virus infection and the host-virus interactions during this time. In the second part of this PhD project we made use of the acute hepatitis C liver biopsies collected over the course of several years at the University Hospital of Basel to describe human hepatic response to acute hepatitis C virus infection and gain an insight into the mechanism of improved cure rate compared to chronic hepatitis C (see Section 3.2).
Chronic hepatitis C is currently treated with combination therapies based on pegylated interferon- alpha. A significant proportion of patients fails to respond to the current treatment options, probably due to the refractory state of the preactivated endogenous interferon system in the liver. Several compounds are currently in clinical development with the aim to improve the treatment outcome of pegylated interferon�alpha nonresponders. In the last part of this work we investigated in vivo the mode of action
of a novel synthetic TLR9 agonist which is a clinical candidate for anti-hepatitis C virus therapy
and characterized the hepatic response to this compound (see Section 3.3)
myExperiment: a repository and social network for the sharing of bioinformatics workflows
No full textmyExperiment (http://www.myexperiment.org) is an online research environment that supports the social sharing of bioinformatics workflows. These workflows are procedures consisting of a series of computational tasks using web services performed on data from its retrieval, integration and analysis, to the visualisation of the results. As a public repository of workflows, myExperiment allows anybody to discover those that are relevant to their research which can then be reused and repurposed to their specific requirements. Conversely, developers can submit their workflows to myExperiment and enable them to be shared in a secure manner. Since its release in 2007, myExperiment currently has over 3500 registered users and contains more than 900 workflows. The social aspect to the sharing of these workflows is facilitated by registered users forming virtual communities bound together by a common interest or research project. Contributors of workflows can build their reputation within these communities by receiving feedback and credit from individuals who reuse their work. Further documentation about myExperiment including its REST web service is available from http://wiki.myexperiment.org. Feedback and requests for support can be sent to [email protected]
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