1,317 research outputs found
Changes in viral load and HBsAg and HBeAg status with age in HBV chronic carriers in The Gambia.
No full textBACKGROUND: Little is known about changes in hepatitis B viral load (HBV DNA) in relation to age in Africa. The aim of this study is to determine the natural course of HBV chronic infection, particularly in relation to sequential changes in serum HBV DNA levels and hepatitis B surface (HBsAg) antigen/hepatitis e antigen (HBeAg) status by age. METHODS: The study was conducted on 190 HBV chronic carriers, aged 1-19 years who were followed for 19 years. 160, 99 and 123 were traced at 5, 9 and 19 years later. All available samples were tested for HBsAg and HBeAg, whilst 170, 61, 63 and 81 were tested for HBV DNA at the baseline, and at 5, 9 and 19 years following recruitment. RESULTS: In general HBeAg which correlated with high levels of HBV DNA was lost at a much faster rate than HBsAg. 86% of the carriers who were recruited at the age of 1-4 yrs lost HBeAg by the age of 19 years compared to 30% who lost HBsAg. HBeAg negative carriers had serum HBV DNA levels of < 105 copies per mL, HBV DNA positivity declined from 100% in 1-4 yrs old carriers at recruitment to 62.5%,60% and 88% at 5, 9 and 19 years respectively following recruitment. CONCLUSION: After 19 years of follow up, the majority of HBV surface antigen carriers had lost HBeAg positivity and had low levels of viral replication. However small proportions (10-20%) retained HBeAg and continue to have high levels of viral replication
The UNESCO Interdisciplinary Chair in Biotechnology and Bioethics (2000-2009): An example of Responsible Research and Innovation between Europe and Africa,
No full textDe Finetti and the Arrow-Pratt measure of risk aversion
No full textViene descritta l'analisi dell'avversione al rischio proposta da de Finetti e mostrato come la misura dell'avversione al rischio da lui proposta coincida con quella introdotta più di dieci anni dopo da Arrow e Pratt
PROTEIN KINASE C-ALPHA AND -DELTA ARE REQUIRED FOR NADPH OXIDASE ACTIVATION IN WKYMVm-STIMULATED IMR90 HUMAN FIBROBLASTS
No full textThe regulation of the activation of non phagocytic NADPH oxidase is poorly understood. Previously we demonstrated that in fibroblasts the exposure to WKYMVm induced p47phox phosphorylation and translocation and that these effects were mediated by ERKs activation. Protein kinase C (PKC) is reported to be involved in regulating the phosphorylation of NADPH oxidase components in polymorphonucleate cells stimulated via FPRL1 receptor, but its involvement in fibroblasts was not demonstrated. Therefore, we investigated in IMR90 cells exposed to WKYMVm the role of PKC isoenzymes in the activation of NADPH oxidase-like enzyme. Preincubation with general pharmacological inhibitors of PKC, before stimulation with WKYMVm, prevented the ERKs activation, p47phox phosphorylation and translocation. The analysis of cellular partitioning of PKC isoenzymes demonstrated that PKCa and PKCd translocated from the cytosolic to the membrane fraction upon stimulation with WKYMVm. Preincubation with Go6976 or with rottlerin prevented the phosphorylation and translocation of NADPH oxidase regulatory subunit
Donkey engine and crew, Wynooche Timber Company, near Montesano, Grays Harbor County, Washington, approximately 1921
No full textCaption on image: Wynoche Log. Co. Montesano, Wn. C. Kinsey Photo, Seattle. No. 70
PH Coll 516.5166The Wynooche Timber Company began operations ca. 1913 with headquarters in Hoquiam and logging operations in Montesano. It was named for Wynooche Valley in northeast Grays Harbor County. Wynooche Timber Company was bought out by Schafer Brothers Logging Company ca. 1927.
Montesano, the county seat of Grays Harbor County, is eight miles east of Aberdeen on the Chehalis River near the mouth of Wynooche River in central Grays Harbor County. In 1862, the name Mount Zion was suggested by the wife of the first settler, J. L. Scammon. Another pioneer, Samuel James, suggested the present name from the Spanish monte or mountain, and sano or health. Local authorities thought Sam's name had more meaning
Donkey engine and crew, Wynooche Timber Company, near Montesano, Grays Harbor County, Washington, approximately 1921
No full textCaption on image: Wynoche Log. Co., Montesano, Wn. C. Kinsey Photo, Seattle. No. 64
PH Coll 516.5161The Wynooche Timber Company began operations ca. 1913 with headquarters in Hoquiam and logging operations in Montesano. It was named for Wynooche Valley in northeast Grays Harbor County. Wynooche Timber Company was bought out by Schafer Brothers Logging Company ca. 1927.
Montesano, the county seat of Grays Harbor County, is eight miles east of Aberdeen on the Chehalis River near the mouth of Wynooche River in central Grays Harbor County. In 1862, the name Mount Zion was suggested by the wife of the first settler, J. L. Scammon. Another pioneer, Samuel James, suggested the present name from the Spanish monte or mountain, and sano or health. Local authorities thought Sam's name had more meaning
Loggers and mess hall crew at logging camp, Wynooche Timber Company, near Montesano, Washington, approximately 1921
No full textCaption on image: Wynoche Log. Co. Montesano, Wn. C. Kinsey Photo, Seattle. No. 62
PH Coll 516.5159The Wynooche Timber Company began operations ca. 1913 with headquarters in Hoquiam and logging operations in Montesano. It was named for Wynooche Valley in northeast Grays Harbor County. Wynooche Timber Company was bought out by Schafer Brothers Logging Company ca. 1927.
Montesano, the county seat of Grays Harbor County, is eight miles east of Aberdeen on the Chehalis River near the mouth of Wynooche River in central Grays Harbor County. In 1862, the name Mount Zion was suggested by the wife of the first settler, J. L. Scammon. Another pioneer, Samuel James, suggested the present name from the Spanish monte or mountain, and sano or health. Local authorities thought Sam's name had more meaning
Donkey engine and crew, Wynooche Timber Company, near Montesano, Grays Harbor County, Washington, approximately 1921
No full textCaption on image: Wynoche Logg. Co., Montesano, Wn. C. Kinsey Photo, Seattle. No. 59
PH Coll 516.5156The Wynooche Timber Company began operations ca. 1913 with headquarters in Hoquiam and logging operations in Montesano. It was named for Wynooche Valley in northeast Grays Harbor County. Wynooche Timber Company was bought out by Schafer Brothers Logging Company ca. 1927.
Montesano, the county seat of Grays Harbor County, is eight miles east of Aberdeen on the Chehalis River near the mouth of Wynooche River in central Grays Harbor County. In 1862, the name Mount Zion was suggested by the wife of the first settler, J. L. Scammon. Another pioneer, Samuel James, suggested the present name from the Spanish monte or mountain, and sano or health. Local authorities thought Sam's name had more meaning
Loading site beside holding pond, Wynooche Timber Company, near Montesano, Washington, approximately 1921
No full textCaption on image: Wynoche Log. Co., Montesano, Wn. C. Kinsey Photo, Seattle. No. 66
PH Coll 516.5163The Wynooche Timber Company began operations ca. 1913 with headquarters in Hoquiam and logging operations in Montesano. It was named for Wynooche Valley in northeast Grays Harbor County. Wynooche Timber Company was bought out by Schafer Brothers Logging Company ca. 1927.
Montesano, the county seat of Grays Harbor County, is eight miles east of Aberdeen on the Chehalis River near the mouth of Wynooche River in central Grays Harbor County. In 1862, the name Mount Zion was suggested by the wife of the first settler, J. L. Scammon. Another pioneer, Samuel James, suggested the present name from the Spanish monte or mountain, and sano or health. Local authorities thought Sam's name had more meaning
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