2,083 research outputs found
Sustaining olfaction at low salinities: mapping ion flux associated with the olfactory sensilla of the blue crab Callinectes sapidus
No full textTo test the hypothesis of a diffusion-generated, ionic/osmotic microenvironment within the olfactory sensilla (aesthetases), flux gradients of Ca2+ and K+ associated with the external surfaces of these sensilla were spatially mapped using self-referencing, ion-selective microelectrodes. Blue crabs (Callinectes sapidus) acclimated to low-salinity conditions (15% sea water and fresh water) showed a net efflux of ions from the aesthetases. The region of maximum flux associated with each aesthetase conformed to that predicted from structural data and corresponded to the permeable region of the cuticle separating the olfactory dendrites from the external environment. Estimates of net flux from the entire tuft of aesthetases for both Ca2+ and K+ fell within the predicted range on the basis of comparisons with (22)Na+ flux measured previously and assuming a passive diffusion model of ion movement from the hemolymph to the sensillar lymph and, ultimately, to the external environment. The maximum concentrations of these ions measured deep within the tuft are discussed in the light of a potential across the aesthetases that may limit ion efflux at low salinities
Seventh Legislative Council
No full textSeventh(?) Legislative Council.
Standing, left to right: K. C. Waters (Arnhem); D. Hogan (Clerk Assistant); B. F. Kilgariff (Non Official); F. W. Drysdale (Nightcliff); W. M. Curteiss (Director of Agriculture); R. C. Ward (Port Darwin); D. D. Smith (Stuart); H. Chan (Fannie Bay); H. Brennan (Elsey); C. F. Adams (Director of Mines); A. L. Rose (Alice Springs); R. J. Withnall (Crown Law Officer); J. H. Whittem (Director of Animal Industry); D. N. Mathieson (Non Official); F. H. Walker (Clerk).
Seated, left to right: L. H. Purkiss (Barkly); H. C. Giese (Director of Welfare); R. B. Nott (President and Administrator); H. C. Barclay (Director of Lands); W. J. Fisher (Non Official).Gleeson, N.Date:196
Joint angle affects volitional and magnetically-evoked neuromuscular performance differentially
No full textThis study examined the volitional and magnetically-evoked neuromuscular performance of the quadriceps femoris at functional knee joint angles adjacent to full extension. Indices of volitional and magnetically-evoked neuromuscular performance (N= 15 healthy males; 23.5 ± 2.9 years; 71.5 ± 5.4 kg; 176.5 ± 5.5 cm) were obtained at 25°; 35° and 45° of knee flexion. Results showed that volitional and magnetically-evoked peak force (PFV; PTFE, respectively) and electromechanical delay (EMDV; EMDE, respectively) were enhanced by increased knee flexion. However, greater relative improvements in volitional compared to evoked indices of neuromuscular performance were observed with increasing flexion from 25° to 45° (e.g. EMDV; EMDE: 36% vs. 11% improvement, respectively; F[2,14] = 6.8; p < 0.05). There were no significant correlations between EMDV and EMDE or PFV and PTFE, respectively at analogous joint positions. These findings suggest that the extent of the relative differential between volitional and evoked neuromuscular performance capabilities is joint angle-specific and not correlated with performance capabilities at adjacent angles, but tends to be smaller with increased flexion. As such, effective prediction of volitional from evoked performance capabilities at both analogous and adjacent knee joint positions would lack robustness
Comment on C.E. Close, M.R. Gleeson and J.T. Sheridan Monomer Diffusion Rates in Photopolymer Material Part 1. Low Spatial Frequency Holographic Gratings
No full textCOMMENT: on C. E. Close, M. R. Gleeson and J. T. Sheridan “Monomer diffusion rates in photopolymer material.Part I. Low spatial frequency holographic gratings” J. Opt. Soc. Am. B / Vol. 28, No. 4 / April 2011 pp 658- 666 [1
Psychotherapies for the psychoses : theoretical, cultural and clinical integration/ Edit.: John F. M. Gleeson
No full textxviii, p. 270: ind., tab.; 29 c
The Assisted Decision-making Capacity Act, 2015: reflections for the profession of social work
No full textThe Assisted Decision-Making (Capacity) Act 2015 will provide the legal framework to maximise a person’s right to make their own decisions, with legally recognised supports. Once commenced, this significant piece of legislation will change everyone’s approach when working with and supporting people whose capacity is in question. This collection of essays, written from both personal and professional perspectives, highlights the importance of this ground-breaking piece of legislation. The powerful essays demonstrate the scale of impact that the Act may have on people’s lives — from the ability to write a legally binding advance healthcare directive to being supported to make their own decisions if they have difficulties with decision-making capacity. The idea for this collection of essays emerged from a conference held in University College Cork in November 2019, which was jointly organised by the Decision Support Service; the HSE National Office for Human Rights and Equality; and the Law School at UCC. The conference was intended to draw attention to the ongoing delays in commencing the Assisted Decision-Making (Capacity) Act 2015 (the 2015 Act). At that time, there was no clear line to commencement and a growing concern that there was no political imperative to take the steps needed to bring the 2015 Act into force. We wanted to provide a reminder of the unsustainability of the current legal structures, the importance of the 2015 Act and why political procrastination had to stop
The earth's climate at the end of the century
No full textLocal climate is dependent on the global climate. Here, a global picture on climate change is presented using predictions from the EC-Earth simulations for the end of the century. The results indicate a general rise in annual mean temperature everywhere: 2-4 degrees (global average), 1-6 degrees (over Europe) and 1-4 degrees (Ireland). Changes in precipitation are more varied: large increases (>100%) at high northern latitudes and in the equatorial Pacific but decreases of more than 50% over the subtropics; winters in Europe are predicted to be up to 20% wetter and summers up to 20% drier. Changes in extremes are also presented in this chapter
PAK3 mutation in nonsyndromic X-linked mental retardation
No full textNonsyndromic X-linked mental retardation (MRX) syndromes are clinically homogeneous but genetically heterogeneous disorders, whose genetic bases are largely unknown. Affected individuals in a multiplex pedigree with MRX (MRX30), previously mapped to Xq22, show a point mutation in the PAK3 (p21-activated kinase) gene, which encodes a serine-threonine kinase. PAK proteins are crucial effectors linking Rho GTPases to cytoskeletal reorganization and to nuclear signalling. The mutation produces premature termination, disrupting kinase function. MRI analysis showed no gross defects in brain development. Immunofluorescence analysis showed that PAK3 protein is highly expressed in postmitotic neurons of the developing and postnatal cerebral cortex and hippocampus. Signal transduction through Rho GTPases and PAK3 may be critical for human cognitive function.Kristina M. Allen ; Joseph G. Gleeson ; Shubha Bagrodia ; Michael W. Partington ; John C. Macmillan ; Richard A. Cerione ; John C. Mulley ; Christopher A. Wals
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