6,146 research outputs found

    Application of product data management within the product development process

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    Manufacturing companies need to be able to respond to customer demand quickly and accurately. This requires the capability to manage product data effectively. Product Data Management (PDM) systems have been identified as a solution to deliver this capability by providing the right information to the right people at the right time and in the right format. The foundation of this research is that the concept of PDM is relevant and important within the product development process. This research focuses upon how the PDM concept is applied in practice to define and configure products and how it can be integrated with other major information systems to enable an enterprise wide information system. To enable the research aim, an extensive review of literature was undertaken to investigate the effectiveness of PDM in enhancing the product definition process and in creating an interface between different business functional areas. A survey ofPDM system usage was undertaken aimed at identifying the current level of PDM usage within manufacturing enterprises in the UK. This was followed up by three industrial case studies to provide some degrees of validation of the results obtained. A need for effective one time order capture was identified from the three case studies which led to the development of a model specification for a late product configuration tool. A prototype system was produced to validate the design specification and was successfully demonstrated to a collaborating company. During the submission of this thesis, the collaborating company and the university are working on funding a project to pursue with its implementation. The work undertaken has firmly established the relevance ofPDM within the product development process and the importance of effective interfaces between PDM and other manufacturing information systems. The research will be of interest to small and medium sized manufacturing companies searching solutions for improving the management of their product data to enhance product definition and configuration

    RNA-sequencing data of Balb/c involuting mammary gland treated with anti-Ly6G antibody and estrogen

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    Female Balb/c mice were oxvariectomed at lactation day 2, pups forced weaned at lactation day 12 to initiate mammary involution. At 24 hours post-weaning, mice were treated with anti-Ly6G antibodies or isotype control. At 48 hours post-weaning, mice were treated with 20µg/kg of body weight estrogen or vehicle control. Mice sacrificed after 24 hours estrogen treatment and mammary sample collected and frozen. Mammary samples were extracted for total RNA using Trizol reagen and then treated with Dnase1 before sending for library preparation and sequencing by A*STAR GIS using illumina HiSeq4000

    Typical results of a triaxial test for a sample of frozen soil at -20°C and 10 MPa stress condition, after Leng [33].

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    Typical results of a triaxial test for a sample of frozen soil at -20°C and 10 MPa stress condition, after Leng [33].</p

    FIGURE 6 in A new species of Leptobrachella (Anura, Megophryidae) from Mount Pu Ta Leng northwest Vietnam

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    FIGURE 6. (A) Macrohabitat of of Leptobrachella graminicola sp. nov. Mount Pu Ta Leng, Bat Xat District, Lao Cai Province, (B) microhabitat of Leptobrachella graminicola sp. nov. Mount Pu Ta Leng, Bat Xat District, Lao Cai Province, and (C) specimens of Leptobrachella graminicola sp. nov. in situ.Published as part of Nguyen, Luan Thanh, Tapley, Benjamin, Nguyen, Chung Thanh, Luong, Hao Van & Rowley, Jodi J.L., 2021, A new species of Leptobrachella (Anura, Megophryidae) from Mount Pu Ta Leng northwest Vietnam, pp. 301-332 in Zootaxa 5016 (3) on page 322, DOI: 10.11646/zootaxa.5016.3.1, http://zenodo.org/record/522218

    Guo leng ba gui he jin de wei guan jie gou

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    Ding, Heyi = 過冷鈀硅合金的微觀結構 / 丁赫一.Thesis M.Phil. Chinese University of Hong Kong 2014.Includes bibliographical references.Abstracts also in Chinese.Title from PDF title page (viewed on 15, November, 2016).Ding, Heyi = Guo leng ba gui he jin de wei guan jie gou / Ding Heyi

    The date of the Leng-chia shih-tzu chi

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    Among the many manuscripts relating to Ch’an Buddhism included in the Tun-huang finds of the early years of this century, the Leng-chia shih-tzu chi has always been regarded by scholars as a discovery of unusual importance, since it presents an unrivalled picture of the early development of this type of Buddhism from the long-obscured viewpoint of the so-called Northern school of Ch’an. The text has been rendered into English lately by J. C. Cleary, but only in a translation intended for a non-scholarly audience. Fortunately, however, the new French-language translation and study by Bernard Faure is everything a scholar could wish for, a worthy product of many years of research, including several spent at the feet of Yanagida Seizan, Japan's outstanding authority on the early historiography of Ch’an. Faure's work, not surprisingly, shows a complete grasp of the complex issues of intellectual history raised by his text, and also provides copious commentary on its author, Ching-chüeh (683–c. 750), and his background.</jats:p

    The origins of carbonatites and related rocks from the Grønnedal-Íka Nepheline Syenite complex, South Greenland: C-O-Sr isotope evidence

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    The Grønnedal-Íka ring complex (1299 ± 17 Ma) in the Gardar province, South Greenland is composed of a range of layered nepheline syenites which were intruded at a late stage by xenolithic syenite and a plug of carbonatite. The complex was subsequently intruded by a variety of basic dykes, including olivine dolentes, kersantites, vogesites, spessartites, camptonites and an alnöite, and then extensively faulted. The nepheline syenite magmas, produced by fractional crystallisation of basic magmas, show a range in δ13C (-3.86 to -7.57‰) and δ18O (8.27 to 15.12‰), distinctly different to the carbonatites which form a tight group with average δ13C= -4.31 ± 0.22 ‰, (1 s.d.) and average δ18O= 7.18 ± 0.41‰(1 s.d.). Initial 87Sr/86Sr isotope ratios (typically 0.703) suggest the syenites and carbonatites have not assimilated crustal rocks, and therefore the C and O isotope variation within each group is a result of isotopic evolution during fractional crystallisation. A suite of lamprophyre dykes (δ13C -3.86 to -7.86‰ and δ18O 9.12 to 10.81‰) form a coherent group whose stable isotope compositions overlap part of the syenite field, and again are distinctly different from the carbonatites. A single alnöite has δ13C = -3.32‰ and δ18C= 12.34‰. C and O isotope ratios are consistent with origins of syenitic and lamprophyric magmas from a similar source. Despite geochemical evidence which suggests a genetic link between nepheline syenites and carbonatites, C and O isotopic evidence shows that they are not related directly by liquid immiscibility. Comparisons are made between similar rock types from Grønnedal-Íka and from the Gardar Igaliko Dyke Swarm. The possible role of F in controlling δ13C and δ18O during crystallisation of calcite from carbonatite magmas is discussed

    The Antigastric Cancer Activity of San Leng Powder Extract Induces Apoptosis in Balb/C Bearing-SGC-7901 Mice

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    San Leng powder extract has been used as medicinal compound for the prevention and treatment of cancers. The antitumor activity of SLPE was determined by treating BALB/C mice harboring a human gastric cancer xenograft with SPLE for 17 days. Mice were also treated with fluorouracil (5-Fu, 25 mg/kg) or a combination of SLPE and 5-Fu. Our results indicate that the inhibition of tumor growth by SLPE might be due to a block in the cell cycle and the induction of apoptosis. These results suggest that SLPE might be useful in the treatment of gastric cancer.</jats:p
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