642 research outputs found
R. N. Ironside and I. R. C. Batchelor, Aviation neuro-psychiatry
No full textNuttin J. R. N. Ironside and I. R. C. Batchelor, Aviation neuro-psychiatry. In: Revue Philosophique de Louvain. Troisième série, tome 44, n°1, 1946. p. 180
R. N. Ironside and I. R. C. Batchelor, Aviation neuro-psychiatry
No full textNuttin J. R. N. Ironside and I. R. C. Batchelor, Aviation neuro-psychiatry. In: Revue Philosophique de Louvain. Troisième série, tome 44, n°1, 1946. p. 180
Meet the next generation: Rachael Ironside.
No full textThis feature focuses on the next generation of scientists and scholars researching parapsychological topics. The author talks of her journey inside parapsychology, what is her biggest accomplishment and future research plans
Geology of the Ironside Mountain quadrangle, Oregon
No full textThis archived document is maintained by the Oregon State Library as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposes.Title from PDF cover (viewed on September 22, 2015).Includes bibliographical references (pages 73-76).Mode of access: Internet from the Oregon Government Publications Collection.Text in English
A liénard oscillator resonant tunnelling diode-laser diode hybrid integrated circuit: model and experiment
No full textWe report on a hybrid optoelectronic integrated circuit based on a resonant tunnelling diode driving an optical communications laser diode. This circuit can act as a voltage controlled oscillator with optical and electrical outputs. We show that the oscillator operation can be described by Liénard's equation, a second order nonlinear differential equation, which is a generalization of the Van der Pol equation. This treatment gives considerable insight into the potential of a monolithic version of the circuit for optical communication functions including clock recovery and chaotic source applications
Reconstructing the evolution of the Ironside Mountain batholith, northern California through textural and single-mineral compositional analyses of pyroxene, amphibole, and plagioclase
No full textThe ~170-168 Ma Ironside Mountain batholith in northern California encompasses the Ironside Mountain pluton, quartz diorite of Happy Camp Mountain, Wildwood pluton, West China Peak complex, and Denny complex. The Ironside Mountain batholith was emplaced within ca. two m.y. after regional thrusting attributed to the Siskiyou orogeny. Single-mineral compositions in clinopyroxene, hornblende, and plagioclase were measured in-situ by electron-probe micro-analyses and laser ablation inductively coupled plasma mass spectrometry and coupled with bulk rock X Ray Fluorescence analyses.
Mineral data revealed two compositionally diverse magmas within the Ironside Mountain batholith: A) those of the Ironside Mountain pluton, quartz diorite of Happy Camp Mountain, and Wildwood pluton, which are characterized by two- and three-pyroxene assemblages + ilmenite +magnetite, scant amphibole and biotite, low Mg number, low Cr concentrations, and rare earth element abundances in clinopyroxene and amphibole to 300 times chondrites with deep negative europium anomalies; and B) those of the Denny and West China peak complexes, which are characterized by 2-pyroxene assemblages, have rare earth element abundances in clinopyroxene and amphibole to 50 and 100 times chondrites, respectively, with small to absent europium anomalies. Europium anomalies in clinopyroxene and amphibole of group A suggest crystallization from plagioclase-fractionated melts. Early plagioclase crystallization indicates magmas with low f(H2O). Small to absent europium anomalies in clinopyroxene and hornblende of group B suggests these minerals were liquidus phases without plagioclase, which indicates higher f(H2O). Lower Cr abundances and Mg numbers in clinopyroxene and amphibole from group A suggests their magmas were evolved.
Rimming relationships between clinopyroxene, orthopyroxene, and inverted pigeonite, and the absence of clear fractionation trends in major and trace element data of pyroxene and amphibole indicates magmas of the Ironside Mountain pluton did not evolve as a single closed system. Iron-Mg exchange coefficients higher than equilibrium values in amphibole, clinopyroxene, and orthopyroxene; Ab-An exchange coefficients higher than equilibrium values in plagioclase; and the fact that melts calculated from augite compositions display deep negative europium anomalies, but such anomalies are absent in bulk rock rare earth element patterns, indicates partial accumulation of Ca-rich plagioclase, orthopyroxene, and clinopyroxene occurred.
Clinopyroxene and amphibole compositions from the Ironside Mountain pluton and coeval Wildwood pluton are distinct from those of the Western Hayfork arc. Barnes and Barnes (2020) showed the predominant magma types erupted from the Western Hayfork arc were calc-alkaline or high-Mg andesites and dacites, the latter of which experienced fractionation of garnet at depth. The lack of negative europium anomalies in Western Hayfork augite and hornblende suggests plagioclase was absent early in the crystallization history, which is further evidence of H2O-rich and oxidized magmas (Muntener and others, 2001). Along with the geologic relationships reported by Barnes and others (2006), the compositional distinctions between Western Hayfork arc and Ironside Mountain pluton parental magmas refute the hypothesis that the Ironside Mountain pluton is the intrusive equivalent of the Western Hayfork arc.Restricted until 06/2027. To request the author grant access, click on the PDF link to the left
Investigation into the integration of a resonant tunnelling diode and an optical communications laser: model and experiment
No full textA resonant tunnelling diode has been monolithically integrated with an optical communications laser [the resonant tunnelling diode (RTD-LD)] to form a simple optoelectronic integrated circuit (OEIC) that is a novel bistable device suitable for an optical communications system. The RTD-LD was based on a ridge-waveguide laser structure and was fabricated from an InAlGaAs-InP epi-wafer grown by molecular beam epitaxy; it emitted at around 1500 nm. Voltage controlled optical-electrical switching and bistability were observed during the characterisation of the RTD-LD - useful features for a fibre-optic communications laser. Optical and electrical simulations of the RTD-LD were carried out using the circuit simulation tool PSPICE. In addition, a discrete component version of the RTD-LD was constructed which exhibited optical power oscillations, and along with the results of the simulations, gave insight into the operating principles of the monolithically integrated RTD-LD
Neuropathology and molecular biology of iatrogenic Creutzfeldt-Jakob disease in UK human growth hormone recipients
No full textCreutzfeldt-Jakob disease (CJD) is the commonest form of human prion disease and
occurs in sporadic, genetic and acquired forms. The causative agents (prions) appear
to be composed entirely of a modified host protein, the prion protein, which
undergoes misfolding to a disease-associated isoform closely associated with
infectivity that is resistant to conventional methods of decontamination. Prions can
be transmitted from one individual to another by medical and surgical procedures,
resulting in iatrogenic CJD (iCJD). The commonest cause of iCJD is the inoculation
of cadaveric pituitary-derived human growth hormone (hGH) to treat growth
hormone deficiency in children; this form of treatment was abandoned in 1985 after
the first UK case of iCJD in a hGH recipient was identified. Seventy-eight cases of
iCJD have since occurred in the UK cohort of 1849 hGH recipients, including a case
in 2016.
This thesis describes a comprehensive tissue-based and molecular genetic analysis of
the largest series (35 cases) of UK hGH-iCJD cases reported to date, including in
vitro kinetic molecular modelling of genotypic factors influencing prion
transmission. The results show that the polymorphism at codon 129 of the prion
protein gene strongly influences the disease incubation period in hGH-iCJD (from
7.8-32.3 years in this series) and interacts with the infectious prion strain to govern
the molecular and pathological characteristics of iCJD. The findings are consistent
with the hypothesis that the UK hGH-iCJD epidemic resulted from transmission of
the V2 human prion strain, which is found in the second most common form of
sporadic CJD.
The investigation also found accumulation of the amyloid beta (Aβ) protein
associated with Alzheimer’s disease (AD) in the brains and cerebral blood vessels in
18/35 hGH-iCJD patients and 5/12 control patients who had been treated with hGH,
but died from causes other than iCJD. In contrast, Aβ accumulation was markedly
less prevalent in age-matched patients who died from sporadic CJD (1/15 cases) and
variant CJD (2/33 cases). These results are consistent with the hypothesis that Aβ,
which can accumulate in the pituitary gland, was present in the inoculated hGH
preparations and seeded into the brains of around 50% of all hGH recipients,
producing AD-like neuropathology and cerebral amyloid angiopathy (CAA). This
provides further evidence of the prion-like properties of Aβ and gives insight into the
potential for possible transmission of AD/CAA. It is uncertain whether any Aβ
seeding within the brains of surviving patients in the UK hGH recipient cohort will
ultimately result in clinical AD; however, the CAA in these patients may be
complicated by intracerebral haemorrhage resulting from rupture of the blood vessels
damaged by Aβ accumulation within their walls
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