2,713 research outputs found
Total synthesis of cavicularin and riccardin C: addressing the synthesis of an arene that adopts a boat configuration
No full textA transannular ring contraction induced by the addition of an aryl radical intermediate to a proximal arene facilitated the construction of the highly strained macrocyclic core of cavicularin (1). The precursor, an iodinated derivative of another natural product, riccardin C, was prepared from four commercially available arenes in a highly convergent sequence
Long-term growth in vitro of isolated, fully differentiated neurones from the central nervous system of an adult insect
No full textA method is described for the isolation and growth in vitro of fully differentiated neurones from the thoracic ganglia of adult cockroaches. The presence of insect blood in the culture system is shown to promote growth. The morphology of the growing neurones and the plasticity of the branching processes are described and growth rates are measured. Using a fluorescent Ca2+ indicator dye, changes of intracellular calcium levels in the growing neurones in response to K+ depolarization have been measured. The results, indicating the presence of voltage-dependent Ca2+ channels on neuronal processes in vitro, show that neurones can be maintained in a functional state for several weeks by this technique. Such preparations could prove useful for studying a variety of physiological and pharmacological properties of neurones, including the mechanisms controlling growth, synapse formation and neuronal interactions with other cell types. <br/
Unified syntheses of cavicularin and riccardin C: addressing the synthesis of an arene adopting a boat configuration
No full textConcise syntheses of the natural products cavicularin (ten steps) and riccardin C (seven steps) are reported. Key features of the new synthetic route are a convergent strategy to assemble acyclic precursors and a sequence of regioselective reduction and halogenation steps to facilitate Wittig macrocyclisation and transannular ring contraction reactions
The synthesis of a natural product family: from debromoisolaurinterol to the aplysins
No full textTotal syntheses of (+/-)-aplysin 1, (+/-)-debromoaplysin 2, (+/-)-isoaplysin 3, (+/-)-aplysinol 4, (+/-)-debromoaplysinol 5, (+/-)-aplysinal 6, (+/-)-isolaurinterol 7 and (+/-)-debromoisolaurinterol 8 are described. Key features are a diastereoselective, sulfur mediated radical cyclisation of diene 12 to give 35; a new radical to polar crossover sequence mediated by Bu3Sn that transforms diene 12 into (+/-)-debromoisolaurinterol 8; and a series of biomimetic cyclisation and oxidation reactions
A total synthesis of (+/-)-1-desoxyhypnophilin: using ring closing metathesis for the construction of cyclic enones
No full textThe paper describes the first total synthesis of (+/-)-1-desoxyhypnophilin, a linear triquinane isolated from the East African mushroom Lentinus crinitus which displays promising antimicrobial activity. The key strategic feature is a new cyclopentannulation method for appending cycloalkenones onto ketones involving sequential use of a ring closing metathesis reaction with a tertiary allylic alcohol and a PCC induced oxidative rearrangement
Toward a Credible Pacifism: Violence and the Possibilities of Politics
No full textAdvocates of pacifism usually stake their position on the moral superiority of nonviolence and have generally been reluctant or unwilling to concede that violence can be an effective means of conducting politics. In this compelling new work, which draws its examples from both everyday experience and the history of Western political thought, author Dustin Ells Howes presents a challenging argument that violence can be an effective and even just form of power in politics. Contrary to its proponents, however, Howes argues that violence is no more reliable than any other means of exercising power. Because of this there is almost always a more responsible alternative. He distinguishes between violent and nonviolent power and demonstrates how the latter can confront physical violence and counter its claims. This brand of pacifism gives up claims to moral superiority but recuperates a political ethic that encourages thoughtfulness about suffering and taking responsibility for our actions.https://repository.lsu.edu/facultybooks/1404/thumbnail.jp
Australian aid to Afghanistan: submission to the foreign affairs, defence and trade reference committee
No full textThis submission is written by Professor Stephen Howes, Director of the Development Policy Centre and Mr Jonathan Pryke a researcher at the Centre. Professor Howes has twenty-five years of experience working in and on aid and development in the AsiaPacific region. Formerly Lead Economist for India with the World Bank and Chief Economist with AusAID, he was a lead author of the Core Group Report on Aid Effectiveness (2006), the review of Australian aid to PNG (2010) and the Independent Review of Aid Effectiveness (2012). He currently serves on the Board of CARE Australia. Jonathan Pryke graduated from the ANU in 2011 with a Masters in Public Policy and Masters in Diplomacy. Ms Alicia Mollaun also contributed to this submission via the provision of a literature survey. Ms Mollaun is a PhD student at the Crawford School working on American aid to Pakistan. She has worked for the Australian Government with PM&C and DFAT, and is currently on leave from DFAT
The prevalence of isolated systolic hypertension in patients 60 years of age and over attending Australian general practitioners
No full textHowes, L G ; Reid, C ; Bendle, R ; Weaving,
Kansas State University : a pictorial history, the first century, 1863-1963
No full textDuring this period, more than 2,500 students attended the Kansas State Agricultural College, of whom one-third were women. It was estimated that three-fourths of the students came from and returned to farms. Through 1890 there were 232 graduates of whom 73 were women. -- excerpt from Chapter 1Citation: University., Kansas State, and Charles C. Howes. Kansas State University : A Pictorial History, the First Century, 1863-1963. [Manhattan, Kan.]: Manhattan, Kan. : Kansas State U, 1962.Call number: LD2668.A5 K3597 196
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