376 research outputs found
Sprachförderung: Der große Wurf fehlt. Interview
No full textKoreik U, Ohm U, Riemer C, Grosche J. Sprachförderung: Der große Wurf fehlt. Interview. Clavis – Schlüssel für die Integration der Migranten in den Arbeitsmarkt: Strategien für Wirtschaft, Verwaltung und Politik. 2009;(1):12-13
Strong Coupling Superconductivity in the Vicinity of the Structural Quantum Critical Point in (CaxSr1-x)3Rh4Sn13
No full textThe family of the superconducting quasiskutterudites (CaxSr1?x)3Rh4Sn13 features a structural quantum critical point at xc=0.9, around which a dome-shaped variation of the superconducting transition temperature Tc is found. Using specific heat, we probe the normal and the superconducting states of the entire series straddling the quantum critical point. Our analysis indicates a significant lowering of the effective Debye temperature on approaching xc, which we interpret as a result of phonon softening accompanying the structural instability. Furthermore, a remarkably large enhancement of 2?/kBTc and ?C/?Tc beyond the Bardeen-Cooper-Schrieffer values is found in the vicinity of the structural quantum critical point. The phase diagram of (CaxSr1?x)3Rh4Sn13 thus provides a model system to study the interplay between structural quantum criticality and strong electron-phonon coupling superconductivity
Additional file 3 of Long-term individualized monitoring of sympatric bat species reveals distinct species- and demographic differences in hibernation phenology
No full textAdditional file 3. Raw data for: F. Meier, L. Grosche, C. Reusch, V. Runkel, J. van Schaik and G. Kerth. BMC Ecology and Evolution, 2022. Long-term individualized monitoring of sympatric bat species reveals distinct species- and demographic differences in hibernation phenology
Unique luminal localization of VGAT-C terminus allows for selective labeling of active cortical GABAergic synapses.
No full textNeurotransmitter uptake into synaptic vesicles is mediated by vesicular neurotransmitter transporters. Although these transporters belong to different families, they all are thought to share a common overall topology with an even number of transmembrane domains. Using epitope-specific antibodies and mass spectrometry we show that the vesicular GABA transporter (VGAT) possesses an uneven number of transmembrane domains, with the N terminus facing the cytoplasm and the C terminus residing in the synaptic vesicle lumen. Antibodies recognizing the C terminus of VGAT (anti-VGAT-C) selectively label GABAergic nerve terminals of live cultured hippocampal and striatal neurons as confirmed by immunocytochemistry and patch-clamp electrophysiology. Injection of fluorochromated anti-VGAT-C into the hippocampus of mice results in specific labeling of GABAergic synapses in vivo. Overall, our data open the possibility of studying novel GABA release sites, characterizing inhibitory vesicle trafficking, and establishing their contribution to inhibitory neurotransmission at identified GABAergic synapses
Separation of variables in path integrals and path integral solution of two potentials on the Poincare upper half-plane
No full textThe author discusses how to separate variables in path integrals. It is assumed that a one-dimensional problem with potential V(x) has an exact solution with energy levels Elambda and wavefunctions Psi lambda . In order to perform the separation of variables, a time transformation is performed back and forth in the path integral which allows one to insert the path integral solution corresponding to the potential V(x). The author illustrates the method by discussing some specific potential problems on the Poincare upper half-plane
Solution of the Fokker-Planck equation with boundary conditions by Feynman-Kac integration.
No full textIn this paper, we apply the results about d and d-function perturbations in order to formulate within the Feynman-Kac integration the solution of the forward Fokker-Planck equation subject to Dirichlet or Neumann boundary conditions. We introduce the concept of convex order to derive upper and lower bounds for path integrals with d and d- functions in the integrand. We suggest the use of bounds as an approximation for the solution.Feynman-Kac integration; Functions; Integration; Path integral; Perturbations theory; SDE;
Concomitant detection of beta-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice
No full textThe disturbed metabolism of beta-amyloid peptides generated from amyloid precursor protein is widely considered as a main factor during the pathogenesis of Alzheimer's disease. A neuropathological hallmark in the brains from cases with Alzheimer's disease are senile plaques mainly composed of hardly soluble beta-amyloid peptides comprising up to 43 amino acids. Age-dependent cortical beta-amyloidosis was also shown in several transgenic mice and old individuals from various mammalian species, e.g., nonhuman primates. beta-Amyloicli(1-42) is believed to be the main component in the core of senile plaques, whereas less hydrophobic beta-amyloid(1-40) predominantly occurs in the outer rim of plaques. Aminoterminally truncated pyroglutamyl-beta-amyloid(pE3-x), was recently found to be a beta-amyloid species of high relevance to the progression of the disease. While a few biochemical studies provided data on the co-occurrence of several beta-amyloid forms, their concomitant histochemical detection is still lacking. Here, we present a novel triple immunofluorescence labelling of amino- and differently carboxy-terminally truncated beta-amyloid peptides in cortical plaques from a case with Alzheimer's disease, senile macaques and baboons, and triple transgenic mice with age-dependent beta-amyloidosis and tau hyperphosphorylation. Additionally, beta-amyloidop(E3-x), and total P-amyloid were concomitantly detected with beta-amyloid peptides ending with amino acid 40 or 42, respectively. Simultaneous staining of several beta-amyloid species reveals for instance vascular amyloid containing beta-amyloid(pE3-x) in Alzheimer's disease and monkeys, and may contribute to the further elucidation of beta-amyloidosis in neurodegenerative disorders and animal models. (C) 2010 Elsevier B.V. All rights reserved
Empirische Inklusionsforschung in bildungsräumlichen Kontexten – Anschlussmöglichkeiten für eine regionale und inklusive Schulentwicklung
No full textStošić P, Thönnes L, Hackbarth A. Empirische Inklusionsforschung in bildungsräumlichen Kontexten – Anschlussmöglichkeiten für eine regionale und inklusive Schulentwicklung. In: Grosche M, Decristan J, Urton K, Jansen NC, Bruns G, Ehl B, eds. Sonderpädagogik und Bildungsforschung – Fremde Schwestern?. klinkhardt forschung. Perspektiven sonderpädagogischer Forschung . Bad Heilbrunn: Julius Klinkhardt; 2020: 138-143
Path integral approach for superintegrable potentials on spaces of non-constant curvature: II. Darboux spaces DIII and DIV
No full textThis is the second paper on the path integral approach of superintegrable systems on Darboux spaces, spaces of non-constant curvature. We analyze five and four superintegrable potentials in the spaces D III and D IV, respectively; these potentials were first given by Kalnins et al. We are able to evaluate the path integral in most of the separating coordinate systems, leading to expressions for the Green's functions, the discrete and continuous wavefunctions, and the discrete energy spectra. In some cases, however, the discrete spectrum cannot be stated explicitly because it is determined by a higher-order polynomial equation. We also show that the free motion in a Darboux space of type III can contain bound states, provided the boundary conditions are appropriate. We can state the corresponding energy spectrum and the wavefunctions. � 2007 Pleiades Publishing, Ltd
Diagnostik in inklusiven Schulen – zwischen Stigmatisierung, Etikettierungs-Ressourcen-Dilemma und förderorientierter Handlungsplanung
No full textNeumann P, Lütje-Klose B. Diagnostik in inklusiven Schulen – zwischen Stigmatisierung, Etikettierungs-Ressourcen-Dilemma und förderorientierter Handlungsplanung. In: Gresch C, Kuhl P, Grosche M, Sälzer C, Stanat P, eds. Schüler*innen mit sonderpädagogischem Förderbedarf in Schulleistungserhebungen. Einblicke und Entwicklungen. Wiesbaden: Springer VS; 2020: 3-28.In diesem Beitrag wird die Frage diskutiert, ob und welche diagnostischen Konzepte in einem inklusiven Schulsystem umgesetzt werden können und sollten und welche Konsequenzen sich daraus für die Erforschung inklusiver Modelle und Praktiken ergeben. Einem historischen Abriss über die Entwicklung unterschiedlicher diagnostischer Perspektiven hinsichtlich der Feststellung sonderpädagogischen Unterstützungsbedarfs folgt eine kritische Diskussion unter den Stichworten Statusdiagnostik versus Prozessdiagnostik. Vor diesem Hintergrund werden Einsatzbereiche, Vorzüge und Nachteile von formellen und informellen Verfahren aus inklusions- und sonderpädagogischer Perspektive betrachtet. Anschließend erfolgt eine Systematisierung unterschiedlicher Zielsetzungen (sonder-)pädagogischer Diagnostik unter besonderer Berücksichtigung ihrer Einsatzbereiche und Umsetzungsformen. Deren möglicher Informationsgehalt sowie die jeweiligen Konsequenzen für empirische Studien in der Bildungsforschung werden zum Abschluss diskutiert
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