1,721,159 research outputs found

    Qualitative risk assessment for the endemisation of Dirofilaria repens in the state of Brandenburg (Germany) based on temperature-dependent vector competence

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    Climate change with an increase in average temperature may be responsible for propagation of temperature-dependent vectors and/or vector-associated pathogens in regions that were previously not endemic. The analysis of climate data of Brandenburg state (Germany) had showed that the extrinsic development of Dirofilaria repens, the causative agent of canine subcutaneous dirofilariosis, was possible from the years 2001 to 2012. This finding, associated to the movement of infected dogs and their relocation from endemic European areas to Germany makes possible a rapid endemization of the infection and highlight the risk for human health, being D. repens a frequent cause of zoonotic infections

    Osservazioni in vitro sulla liberazione di istamina nel sangue di bovini distomatotici: sensibilizzazione passiva dei leucociti

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    Globuli bianchi ottenuti da bovini sani sono stati incubati con siero di bovini con distomatosi e successivamente stimolati con antigeni di F. hepatica; si è osservata una liberazione di istamina significativamente maggiore che nei controlli

    Filarie

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    DECREASE IN HEPATIC-MICROSOMAL UDP-GLUCURONOSYL-TRANSFERASE ACTIVITY IN RATS AND CATTLE WITH FASCIOLIASIS - IMPAIRED INVITRO GLUCURONIDATION OF OXYCLOZANIDE

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    The effects of liver fluke infection (Fasciola hepatica) on hepatic microsomal UDP-glucuronosyltransferase activity have been studied in microsomes from experimentally infected rats and naturally infected cattle to see if they explain the toxic episodes observed in parasite-infected animals subjected to intensive chemotherapy with the flukicidal drug oxyclozanide. Dramatic decreases in the activity of this enzyme system with the typical substrate p-nitrophenol were observed in both animal species, even when little or no degenerative lesions could be seen in the liver parenchyma. In vitro there was a similar loss of glueuronic acid conjugation of oxyclozanide by hepatic microsomes from infected cattle. In vivo this would result in slower elimination of the drug and in drug accumulation

    Liver metabolism of the fasciolicide drug nitroxinil in rats experimentally infected with Fasciola hepatica

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    The urinary excretion of the main metabolites of nitroxinil was greatly reduced in experimentally infected rats
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