3,647 research outputs found
Diacronico, sincronico: per una linguistica dello spazio melottiano. Una conversazione con baukuh e Valter Scelsi
No full textIntervista di Francesco Garutti a Valter Scelsi in occasio della mostra monografica «Fausto Melotti», organizzata dal Nouveau Musée National de Monaco, curata da Eva Fabbris e Cristiano Raimondi, allestita a Villa Paloma su progetto di Valter Scelsi e baukuh. Un ragionamento sul lavoro di allestimento per l'arte contemporane
Effective Labeling of Molecular Surface Points to Matching Cavitiesand Locate Putative Binding Sites
No full textDiscovery of Similar Regions on Protein Surfaces
No full textDiscovery of a similar region on two protein surfaces can lead to important inference about the functional role or molecular interaction of this region for one of the proteins if such information is available for the other. We propose a new characterization of protein surfaces based on a spin image representation of the surfaces that facilitates the simultaneous search of the entire surface of each of two proteins for a matching region. For a surface point, we introduce spin image profiles which are related to the degree of exposure of the point to identify structurally equivalent surface regions in two proteins. Unlike some related methods, we do not assume that a known fixed region of one of the proteins surfaces is to be matched on the other protein surface. Rather, we search for the largest similar regions on each of the two surfaces. In spite of the fact that this approach is entirely geometric and no use is made of physicochemical properties of the protein surfaces or fold information, it is effective in identifying similar regions on both surfaces even when the region corresponds to a binding site on one of the proteins. The discovery of similar regions on two or more proteins also has implications for drug design and pharmacophore identification. We present experimental results from datasets of more than 50 protein surfaces
Correlazione tra biopsia mirata della portio ed esame istologico su pezzo operatorio nell'ambito della prevenzione del cervicocarcinoma
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A case of occipital epilepsy in an elderly woman
No full textA 73-year-old woman experienced stereotype episodes of complex visual hallucinations over five months. Initially, they were rare and consisted of pleasant static pictures emerging from the left visual field, usually lasting 5 to 10 seconds. Subsequently, they became moving, tormenting pictures, recurring several times a day. On admission, neurological examination revealed reduced contact, nystagmus with fast phase to the left and a left homonymous hemianopia. Electroencephalography (EEG) demonstrated recurrent epileptic discharges starting from the right occipital lobe. The EEG showed sporadic occipital epileptiform activity during the attack-free periods. Phenytoin therapy stopped the seizures and normalized the EEG. An ischemic lesion in the right occipital lobe was detected on cerebral magnetic resonance imaging (MRI) with gadolinium. She continued antiepileptic treatment without recurrence of seizures in the following nine months. This observation of vascular damage-related occipital seizures indicates that epilepsy may be the cause of misdiagnosed behavioral and cognitive disturbances in the elderly. Its prompt recognition is important, since treatment may resolve this type of disorder
Association of cyclosporine and 311 nM UVB in the treatment of moderate to severe forms of psoriasis : a new strategic approach
No full textPsoriasis is a T-lymphocyte mediated autoimmune disease. The response to therapies targeting T-lymphocytes suggest that the latter is a key cell in the pathogenesis of the disease. Cyclosporine (CsA) inhibits the proliferation and the IL-2 dependent expansion of T-lymphocytes. Ultraviolet radiation is an effective treatment for psoriasis. Several studies have demonstrated a significant improvement of the therapeutic response when narrow-band radiation is issued by TL-01 fluorescent lamp compared to broadband UVB issued by other fluorescent sources. The effects of UVB on the immune system appear to be limited to the cell-mediated compartment of the immune response. In order to reduce the cumulative dose of UVB and limit the toxicity of drugs in the therapy of psoriasis, phototherapy with UVB has been used as treatment in association with other standard therapies. The purpose of the study is to evaluate, in patients with moderate to severe psoriasis a combined therapy with Cyclosporine A and 311 nm UVB phototherapy
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