551 research outputs found
Lee C. Frischknecht Papers
No full textLee C. Frischknecht has spent his professional life in educational and public broadcasting. In 1964, he joined National Educational Television as its Director of Field Services. There, he coordinated relations with individual stations and aided in organizing the technical operations. Six years later, after overseeing the University of Utah's radio and television station, Frischknecht joined National Public Radio as Director of Network Affairs, performing many of the same functions he had at NET. In 1972, he became NPR's vice president, with duties of corporate and long-range planning. He became president in 1973, focusing most of his efforts on relations with member stations, the Corporation for Public Broadcasting, and Congress. After leaving NPR in 1978 for many consulting projects, Frischknecht joined Arizona State University's station KAET in 1980 as Education Telecommunications Manager. There, he administered all educational and instructional facets of the station's operations until he retired in 1993. He died in 2005. The collection documents Frischknecht's work in public broadcasting from his early work with NET through his tenure at NPR, and ending with his work at KAET
Integrative Post-event Impact Assessment Framework for Volcanic Eruptions: A Disaster Forensic Investigation of the 2011–2012 Eruption of the Cordón Caulle Volcano (Chile)
No full textUnderstanding the complexity of future volcanic impacts that can be potentially induced by the large variability of volcanic hazards and the multiple dimensions of vulnerability of the increasingly interdependent and interconnected societies, requires an in-depth analysis of past events. A structured and inclusive post-event impact assessment framework is proposed and applied for the evaluation of damage and disruption on critical infrastructures caused by the eruption of the Cordón Caulle volcano (Chile) in 2011–2012. This framework is built on the forensic analysis of disasters combined with the techniques of the root cause analysis that converge in a bow-tie tool. It consists of a fault tree connected to subsequent event trees to describe the causal order of impacts. Considering the physical and systemic dimensions of vulnerability, four orders of impact have been identified: i) the first order refers to the physical damage or the primary impact on a component of the critical infrastructure; ii) the second order refers to the loss of functionality in the system due to a physical damage on key components of the system; iii) the third order refers to the systemic impact due to the interdependency and connectivity among different critical infrastructures; and iv) a higher order is related to the consequences on the main economic sectors and to social disruption that can activate an overall damage to the economy of the country or countries affected. Our study in the Argentinian Patagonia shows that the long-lasting impact of the 2011–2012 Cordón Caulle eruption is mostly due to a secondary hazard (i.e., wind remobilisation of ash), which exacerbated the primary impact affecting significantly larger areas and for longer time with respect to primary tephra deposition. In addition, systemic vulnerability, particularly the intrinsic dependencies within and among systems, played a major role in the cascading impact of the analysed communities
The s-process in the Galactic halo: the fifth signature of spinstars in the early Universe?
No full textMalaria: moving beyond the search for magic bullets
No full textGraphical Abstract Round table discussion on challenges and opportunities in malaria research with Elena Levashina, Dominique Soldati‐Favre, Andrew Waters, Friedrich Frischknecht, and Julian Rayner
Forensic assessment of the 1999 Mount Cameroon eruption, West-Central Africa
No full textThe 28March to 22 April 1999 eruption ofMount Cameroon volcano in southwest Cameroon occurred frommultiple
vents along fissures at two sites. Vents opened first at the upper site 1 (2650 m) and were more explosive
than vents at the lower site 2 (1500m), which were more effusive. Earthquakes, lava flows, tephra fall, ballistics
and gas emissions affected the volcano's west and south flanks, including forests, plantations, stock animals,
water supplies, coastal communities and their people. Through an analysis of existing published data and new
interview data, we provide an overview of the environmental, social and economic consequences of these hazards
on infrastructure, human health, and socio-economic and agricultural activities of the four coastal communitiesmost
affected by the eruption: Batoke, Bakingili,Debundscha and Idenau. The collected data provide amore
detailed description of the short- and long-term direct and indirect effects of the eruption and response than has
been provided to date. Sedimentation of tephra and ballistics from site 1 produced both short-term and longlasting
impacts on people, through the contamination of plants and water supplies, which induced impacts on
human health and commercial activities. A ~9.2 km long lava flow erupted from site 2 received significant
short-termattention as it severed the only arterial coastal highway, forced the evacuation of some 600 residents
of Bakingili, and interrupted commerce between communities. The agricultural sector also suffered due to burning
of crops and soils. The only obvious significant benefit of the eruption appears to be that the long lava flowhas
become a tourist attraction, responsible for bringing in money for food, drink and lodging. However, the longterm
cascading effects caused by the hazards have proven to be more severe than the immediate direct and indirect
effects during the eruption
Leucine 255 of Src couples intramolecular interactions to inhibition of catalysis
No full textThe activity of the c-Src tyrosine kinase is regulated through intramolecular interactions between the catalytic and SH2/SH3 domains. However, the exact mechanism by which this occurs remains obscure. In the crystal structure of c-Src, the peptide that links the SH2 and catalytic domain (SH2-CD linker) is sandwiched between the latter and the SH3 domain. A residue in the linker, Leu 255, inserts its side chain into a deep hydrophobic pocket present on the surface of the catalytic domain. To investigate the possible regulatory role of this prominent interaction, we mutated Leu 255 to different hydrophobic residues. We found that the length and 'bulkiness' of the side chain had a profound influence on c-Src regulation. Src-L255V was highly active but showed reduced SH3 accessibility in vitro as well as an altered localization in vivo when compared to other deregulated forms of Src. Our analyses lead us to suggest that the Leu 255-pocket interaction is a critical component of the intramolecular inhibition mechanism of Src family kinases
Vulnerability assessment and risk mitigation: the case of Vulcano Island, Italy
No full textThe paper reports on a comprehensive vulnerability analysis based on a research work developed within the EC ENSURE Project (7FP) dealing with the assessment of different volcanic phenomena and induced mass-movements on Vulcano Island (S Italy) as a key tool for proactive efforts for multi-risk mitigation. The work is mainly focused on tephra sedimentation and lahar hazards and related physical, systemic and mitigation capacities
Trust/untrust is not the same as true/false. lessons learned and ethical questions on the application of untrustworthiness scales to judge individuals
No full textThis special paper reflects on trustworthiness and its implications for scientific medical journals and all the communities they serve: health professionals, policymakers, the public, and a specific discipline, in our case, Physical and Rehabilitation Medicine. We start from a recent episode: a paper claimed the untrustworthiness of two randomised controlled trials (RCTs) published in the European Journal of Physical and Rehabilitation Medicine based on a newly developed trustworthiness scale, used until now only in systematic reviews. This likely represents the first case of applying such a scale focusing on a single leading author. Developing a proper answer to this case led us to present some insights from the perspective of a Journal editor. We discuss the impact of false research results, why trust is needed in science and medicine, the difference between untrust and false results, the problems in judging trustworthiness, the unfortunately weak capacity of the peer review system in preventing these issues, the problems of "post-hoc" judgements and the emerging ethical issues. We conclude with some suggestions for the future based on prevention at the system level
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