216 research outputs found

    La paranoïa et ses environs (sur les traces de D. Cargnello)

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    Sulle tracce del pensiero psicopatologico di D. Cargnello, riteniamo che il concetto di paranoia costituisca, per certe psicosi che si segnalano per la fredda grandiosità e la coerente strutturazione difensiva dell'Io delirante, una categoria nosografica assolutamente non eludibile.

    OSSESSIONE E DELIRIO. DUE MOMENTI DI UNA STESSA CRISI DELL'IDENTITA' DELL'IO.

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    Gli autori affrontano il problema della continuità strutturale e tematica fra ossessione e deliri

    Transoral endoscopic anatomy of the parapharyngeal space: a step-by-step logical approach with surgical considerations

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    Background. Surgical approaches to the parapharyngeal spaces are challenging. Little is known about the transoral perspective of the anatomy of the parapharyngeal space. Thus, transoral approaches are seldom performed, and only for small-sized tumors.Methods. Six freshly injected cadaver heads were dissected to illustrate the transoral surgical anatomy of the parapharyngeal space.Results. The transoral window dominates the parapharyngeal space from the medial pterygoid muscle laterally to the superior constrictor muscle medially. The stylopharyngeus and styloglossus muscles seem to be critical landmarks in this approach. Posterior to these muscles and laterally to the superior constrictor muscle, the internal carotid artery, internal jugular vein, and lower cranial nerves are identifiable.Conclusion. This anatomic study emphasizes the critical role of the superior constrictor, styloglossus, and stylopharyngeus muscles and highlights the concept of a logical step by step technique that allows the identification of important structures and the creation of safe surgical corridors. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 557-561, 201

    Aspetti neurochimici della nocicezione

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    l'articolo descrive i meccanismi fisiologici e psicologici del dolor

    Ellis-van Creveld Syndrome in Grey Alpine Cattle: Morphologic, Immunophenotypic, and Molecular Characterization

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    Ellis-van Creveld (EvC) syndrome is a human autosomal recessive disorder caused by a mutation in either the EVC or EVC2 gene, and presents with short limbs, polydactyly, and ectodermal and heart defects. The aim of this study was to understand the pathologic basis by which deletions in the EVC2 gene lead to chondrodysplastic dwarfism and to describe the morphologic, immunohistochemical, and molecular hallmarks of EvC syndrome in cattle. Five Grey Alpine calves, with a known mutation in the EVC2 gene, were autopsied. Immunohistochemistry was performed on bone using antibodies to collagen II, collagen X, sonic hedgehog, fibroblast growth factor 2, and Ki67. Reverse transcription polymerase chain reaction was performed to analyze EVC1 and EVC2 gene expression. Autopsy revealed long bones that were severely reduced in length, as well as genital and heart defects. Collagen II was detected in control calves in the resting, proliferative, and hypertrophic zones and in the primary and secondary spongiosa, with a loss of labeling in the resting zone of 2 dwarfs. Collagen X was expressed in hypertrophic zone in the controls but was absent in the EvC cases. In affected calves and controls, sonic hedgehog labeled hypertrophic chondrocytes and primary and secondary spongiosa similarly. FGF2 was expressed in chondrocytes of all growth plate zones in the control calves but was lost in most EvC cases. The Ki67 index was lower in cases compared with controls. EVC and EVC2 transcripts were detected. Our data suggest that EvC syndrome of Grey Alpine cattle is a disorder of chondrocyte differentiation, with accelerated differentiation and premature hypertrophy of chondrocytes, and could be a spontaneous model for the equivalent human disease
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