83,500 research outputs found
Psychological and cultural insights into consumption of luxury western brands in India
No full textIndia has always had wealthy elites such as the maharajas, upper class and royalty that consume luxury products throughout its consumption history. The relatively recent economic rise of the middle class with an increase in disposable income is leading to consumption of luxury en mass. This qualitative study examines why consumers buy luxury, what they believe luxury is and how their perception of luxury impacts buying behaviour in the context of India. The present study explores luxury constructs drawn from the literature and provides some explanation for luxury consumption behaviour in India. The findings reveal that psychological and cultural factors in Indian society play a major part in shaping luxury consumption. While the findings suggest little support for homogenous luxury preference, Indian consumers share cultural characteristics of lavish consumption of luxury and display of wealth in social functions. Luxury reflects conspicuous consumption and status, and signals wealth for individuals, and conveys social identity and status in Indian society
The Role of Relationally Embedded Network Ties in Resource Acquisition of British Nonprofit Organizations
No full textAs nonprofit and charity organizations face increasing competition, there have been growing interests in how nonprofit organizations conduct commercial activities to raise funds as well as grow their business. However, there is lack of prior research about market-oriented and/or commercial activities in the context of nonprofit business. This study examines the process of how nonprofit organizations use relationally embedded network ties to acquire financial, human, and human capital resources to fulfill their social mission and achieve business growth. The study investigates commercial activity of three U.K.-based nonprofit organizations using the case study method. The findings contribute to insights into components of network ties for acquiring three different network resources of financial, human, and human capital. Nonprofit organizations leverage social mission to improve their ability to acquire network resources. The findings also suggest the charity and social mission of nonprofit business enhance trustworthiness in relationally embedded network ties for resource acquisition
Session 2: Mutational discordance: the big challenge in personalized treatments - any solutions?
No full textThe great challenge for oncologists treating patients who are developing or progressing with metastatic disease is to be able to offer a truly personalized and targeted therapy that can have an early and meaningful effect on the course of the disease. At present the known molecular markers are limited in their frequency and reliability in determining the use of newer chemotherapies. Professor Eng discusses the challenges faced in ensuring timely and effective treatments based on the molecular profile of the tumour and the potential role of real-time analysis of mutational changes in the tumour when progression occurs
Functional analysis of a novel ENG variant in a patient with hereditary hemorrhagic telangiectasia (HHT) and pulmonary arterial hypertension (PAH) identifies a new SP1 binding site
No full textObjectives: To investigate the role of a novel intronic ENG variant
found in a Patient with a PAH diagnosis followed by the identification
of typical HHT clinical signs. The pathogenic role of this variant was
demonstrated.
Methods: We analysed all coding exons of ENG, ACVRL1 and
BMPR2 by Sanger sequencing and mlPA. We expressed the ENG
variant in vitro and evaluated protein levels by western blotting. Then,
we confirmed the results by qRT-PCR on an RNA sample of the
Patient. We used in silico tools to evaluate the presence of putative
transcription factor binding-site, changed in the variant. EMSA
analyses were performed to validate the involvement of the transcription
factor Sp1.
Results: We identified the ENG novel variant c.1852 + 42 C[T in a
Patient with both PAH and HHT. No other disease-causing mutation was
found. We proved by western blotting and qRT-PCR that the variant
significantly reduced ENG expression. In silico analyses predicted that the
variant changes a putative binding-site for the transcription factor Sp1,
already demonstrated as involved in ENG expression. By EMSA, we
observed that nuclear extract proteins of human fibroblasts bind with
different affinity wild-type and mutated oligonucleotides.
Conclusion: We identified a novel Sp1 binding-site in ENG intron14.
We demonstrated the pathogenic role of ENG c.1852 + 42 C[T
mutation, which impairs this Sp1 binding-site reducing the transcription
level of the gene. These results stress the importance of
joining genetic findings to functional studies, in order to understand
the role of novel variants of uncertain significance in the disease
pathogenesis
Remote lab experiments models: A comparative study
No full textRemote Laboratory Experimentation (RLE) is a technique used in modern engineering laboratories to help academic researchers and students perform laboratory experiments remotely through the Internet. Many RLE implementations are available with different characteristics. In this work, some recent RLE implementations models are analyzed, the services provided by each model are discussed, and these models are compared and evaluated. © 2006 TEMPUS Publications.ABDULSALAM AO, 2003, P 2 INT C PRINC PRAC, P109; Candelas FA, 2003, INT J ENG EDUC, V19, P363; Chen S.H., 1999, P 1999 IEEE HONG KON, VII, P756; COOPER M, ASCILITE 2002 C P; DELALAMO JA, 2003, LAB WEB, P49; ELHAJJ A, 2004, CIBITIC C MAY BEIR L; FJELDLY TA, 2003, LAB WEB, P1; Henry J, 2003, INT J ENG EDUC, V19, P403; HUA J, 2003, P ASEE NEW ENGL REG; LELEVE A, 2003, ITHET 03 MARR MOROCC; McKee GT, 2003, INT J ENG EDUC, V19, P356; NAGHEDOLFEIZI M, 2002, P 2002 ASEE ANN C EX; Pastor R, 2003, INT J ENG EDUC, V19, P445; Pfleeger S.L., 2001, SOFTWARE ENG THEORY; RODRIGUEZ JA, 1999, INT C ACC LARG EXP P, P483; Serri A, 2003, INT J ENG EDUC, V19, P420; Tan KK, 2003, INT J ENG EDUC, V19, P503; ZIMMER T, 2003, LAB WEB, P8919161
Robust outlier detection in high-density surface electromyographic signals
No full textConf Proc IEEE Eng Med Biol Soc. 2010;2010:4850-3. PubMed PMID: 2109664
<i>Pc-eng-1</i> and <i>Pc-xyl</i> are expressed in the pharyngeal gland cells throughout nematode development.
No full textSchematic representation of a plant-parasitic nematode (A) outlines the pharyngeal gland cells where the digoxigenin-labelled probes of Pc-eng-1 (B) and Pc-xyl (C) are localised. The median bulb is indicated for reference (arrow). No corresponding staining occurred when the negative control probes were used (D and E). Scale = 50 μm. Analysis by qRT-PCR confirmed that Pc-eng-1 and Pc-xyl are both expressed at egg, juvenile (juv), female and male life stages (F). Both genes showed significantly increased expression as the nematode developed. Expression was normalised to Elongation Factor and presented relative to expression in eggs. Values are means ± SEM (n = 3 pools of individuals) with different letters indicating significant differences between treatments P<0.05 (One-way ANOVA, SNK test).</p
Collaborative new product alliances: A review of the literature and research perspectives
No full textAlliance and NPD evolve in a dynamic and interrelated manner so that the management of collaborative NPD alliances becomes the management of an evolving cycle of two interrelated process loops
Non-high-density lipoprotein cholesterol (non-HDL-C) levels in children with nonalcoholic fatty liver disease (NAFLD)
No full textNon-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular disease (CVD) risk in children. Non-high density lipoprotein-cholesterol (non-HDL-C) has been shown to be a good predictor of cardiovascular events. Recent data in adults found non-alcoholic steatohepatitis (NASH) to be associated with significantly higher levels of non-HDL-C than simple steatosis, suggestive it might be used as a non-invasive tool to diagnose NASH. The goal of our study was to assess non-HDL-C levels in children with NAFLD. Our cohort consisted of pediatric patients with biopsy-proven NAFLD. Anthropometric, laboratory, and histologic data were obtained on all patients. Univariable analysis was performed to assess differences in clinical characteristics between groups. Spearman rank correlation coefficients were calculated to assess the correlation between non-HDL-C levels and clinical variables. ANCOVA was used to adjust for possible confounders. 302 subjects with NAFLD were included in our study; 203 with NASH and 99 without NASH. Subjects with NASH had significantly higher non-HDL-C levels than those without (p = 0.004). Histologic features of NASH, including ballooning, inflammation, and fibrosis were found to be weakly correlated with non-HDL-C levels, (p < 0.05 for all). After adjusting for the presence of metabolic syndrome (MetS), ALT, and GGT, the association between non-HDL-C and NASH was not significant (p = 0.66). In Conclusion, non-HDL-C levels are higher in children with NASH than those with simple steatosis, suggesting increased CVD risk. This may be a reflection of the higher prevalence of MetS. Non-HDL-C had a positive association with histologic features of NASH. © 2014 Alkhouri et al.; licensee Springer
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