879 research outputs found
Migrating Cultures and the Dynamic of Exchange/Culture migranti e dinamiche dell'interazione
No full textLe infezioni fungine nel trapiantato
No full textInvasive fungal infections have became one of the principal obstacles to successful solid organ and bone marrow transplantation. The natural history and incidence of systemic fungal infection varies with the type of organ transplanted and the immunosuppressive therapy administered; the majority of infections occur within the first two months after transplantation. The most common fungi that cause disease in transplant recipients are Candida spp. and Aspergillus spp. The clinical presentations of fungal infections in solid-organ transplant recipients are non specific and often overlap with other infectious and non infectious processes; for this reason it's important maintain a high index of suspicion for this type of infection so to start an aggressive diagnostic and therapeutic approach. Difficulty in establishing an etiological diagnosis, lack of effective therapy in certain situations, difficult management of certain antifungal drugs due to toxicity and/or interaction with immunosuppressive drugs, and limited data on effective antifungal prophylactic regimens in solid-organ transplantation represent major problems in the treatment of fungal infection in this population
CD38 expression enhances sensitivity of lymphoma T and B cell lines to biochemical and receptor-mediated apoptosis.
No full textCD38 has been widely characterised both as an ectoenzyme and as a receptor. In the present paper, we investigated the role of CD38 as possible modulator of apoptosis. CD38-positive (CD38(+)) and negative (CD38(-)) fractions, obtained by sorting CD38(+) cells from lymphoma T (Jurkat) and lymphoma B (Raji) and by transfecting lymphoma LG14 and myeloid leukemia K562 cell lines, were used. Cellular subpopulations were exposed to different triggers (H(2)O(2), UV-B, alpha-TOS and hrTRAIL) and the extent of apoptosis was determined by Annexin V-FITC/PI assay. Our data showed that, in lymphoma cells, propensity to apoptosis was significantly linked to CD38 expression and that, remarkably, such response was independent of the nature of the trigger used. Inhibition of CD38 expression by antisense oligonucleotides treatment resulted in CD38-silenced fractions which were as prone to apoptosis as CD38(-) ones. Notably, susceptibility of K562 to apoptosis-inducing challenges was not affected by CD38 expression
A multi-step mechanism for the devolatilization of biomass fast pyrolysis oils
No full textWeight losses in air of four biomass fast pyrolysis oils (BTG, Dynamotive, Ensyn, Pyrovac), measured under
controlled thermal conditions (heating rates of 5, 10, and 20 K/min up to 600 K), are used to formulate a
multistep mechanism. This is based on the introduction of eight lumped classes of volatile products and a
corresponding number of parallel reactions. The reaction rates are linear in the mass fractions of the lumped
product groups and present the usual Arrhenius dependence on temperature. The simultaneous evaluation of
all the measured curves produces the same set of activation energies (46, 65, 71, 80, 72, 84, 102, and 71
kJ/mol) and preexponential factors almost invariant with the bio-oil samples. In this way, the differences in
the reactivity, deriving from the biomass properties and the pyrolysis characteristics, can be taken into account
essentially by the stoichiometric coefficients. A relation is also provided between the eight lumped classes of
products and the volatiles generated from evaporation and thermal cracking of bio-oil (permanent gases and
75 liquid compounds previously quantified)
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